NCT04921787Active, not recruiting
EXHIT ENTRE Implementation Trial of High Intensity Versus Low Intensity Strategy
Exemplar Hospital Initiation Trial to Enhance Treatment Engagement - Implementation Trial of High Intensity Versus Low Intensity Strategy for Supporting Hospital-Based Opioid Use Disorder Treatment
Source: ClinicalTrials.gov · Last updated 23 Apr 2026
Brief summary (registry, in English)
This study is a multi-site, cluster randomized, two group implementation trial comparing a low- versus high-intensity implementation strategy for supporting hospital-based opioid use disorder treatment (HBOT) in community hospital settings where medication for opioid use disorder (MOUD) treatment has not been implemented.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 24 (estimated)
- First submitted
- 11 Mar 2021
- Start date
- 22 Oct 2021
- Primary completion date
- 21 Dec 2026
- Lead sponsor
- Gavin Bart
- NCT number
- NCT04921787
What you commit to
- Study type: Interventional
- Planned participants: 24
- From 22 Oct 2021 to the primary completion date, 21 Dec 2026
- 4 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other
- Have an ACS routinely prescribing MOUD at discharge.
- Have an existing, functioning HBOT program or be imminently starting an HBOT initiative, as confirmed by the investigator team.
- Be a Veterans Affairs hospital.
Who the study is looking for
- Be a community hospital deemed by the lead investigators to be in the region of a site/hub. Region will usually be defined as state unless a compelling case can be made as to geographic feasibility of implementing the intervention and access to relevant Medicaid data.
- Be willing to identify a site champion to promote and adopt change that can address OUD in hospitalized patients.
- Have hospital personnel who state that their institution is interested in and would be willing to work to implement MOUD prior to hospital discharge.
- Commit to having buprenorphine-waivered prescribers willing and able to write prescriptions to bridge discharged patients to post-discharge OUD treatment, or available direct entry into outpatient MOUD with methadone or buprenorphine.
- Have hospital staff who express willingness to engage with a site/hub team for training and for data collection.
- Be willing to be randomized to low-intensity or high-intensity implementation support.
- Provide inpatient general medical care.
- Have sufficient numbers of Medicaid OUD discharges (any listed diagnosis; sufficient is defined as at least enough such that when added to the other hospitals in the region there are on average 100 discharges per year). Medicaid data must capture at least 3 discharge diagnoses, outpatient MOUD, and be available within no more than 12 months of discharge.
Sex: All · Does not accept healthy volunteers
Sites (4)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Boston University Coordinator of this site? Confirm its status | Boston | United States | Unknown status |
| Hennepin Healthcare Research Institute Coordinator of this site? Confirm its status | Minneapolis | United States | Unknown status |
| New York University Coordinator of this site? Confirm its status | New York | United States | Unknown status |
| Oregon Health Science University Coordinator of this site? Confirm its status | Portland | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.