NCT04926948CompletedPhase 1
Stereotactic Body Radiation Therapy With Immunotherapy for the Treatment of Mesothelioma
SBRT With Immunotherapy for Mesothelioma
Source: ClinicalTrials.gov · Last updated 8 Jul 2026
Brief summary (registry, in English)
This phase I trial studies the effect of stereotactic body radiation therapy and immunotherapy in treating patients with mesothelioma. Stereotactic body radiation therapy uses special equipment to position a patient and deliver radiation to tumors with high precision. This method may kill tumor cells with fewer doses over a shorter period and cause less damage to normal tissue. Giving stereotactic body radiation therapy and immunotherapy may improve the tumors response to the treatment and decrease side-effects.
- Status (registry)
- Completed
- Phase (registry)
- Phase 1
- Study type
- Interventional
- Enrollment
- 20 (actual)
- First submitted
- 21 May 2021
- Start date
- 12 Jul 2021
- Primary completion date
- 30 May 2025
- Lead sponsor
- Mayo Clinic
- Diseases
- Mesothelioma
- NCT number
- NCT04926948
What you commit to
- Study type: Interventional · Phase 1
- Participants enrolled: 20
- From 12 Jul 2021 to the primary completion date, 30 May 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other
- Any of the following:
- Pregnant women
- Nursing women
Who the study is looking for
- Age \>= 18 years
- Histological confirmation of pleural mesothelioma
- Measurable disease
- Eastern Cooperative Oncology Group (ECOG) performance status (PS) =\< 2
- Negative pregnancy test done =\< 14 days prior to registration, for women of childbearing potential only. NOTE: male/female: Must be willing to use birth control for the entire study and must agree to use one of the following birth control methods listed:
- Hormonal methods, such as birth control pills, patches, injections, vaginal ring, or implants
- Barrier methods (such as a condom or diaphragm) used with a spermicide (a foam, cream, or gel that kills sperm)
- Intrauterine device (IUD)
- Abstinence (no sex)
- Provide written informed consent
- Willing to return to enrolling institution for follow-up (during the active monitoring phase of the study)
- Willing to provide blood samples for correlative research purposes
- Patient has received or is planning to receive ICI for mesothelioma
- Patient is planning to receive SBRT (stereotactic body radiation therapy) for mesothelioma
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Mayo Clinic in Rochester Coordinator of this site? Confirm its status | Rochester | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.