NCT04928482Recruiting
Responses to Backward Walking Training Post-Stroke
Brain and Behavioral Responses to Backward Walking Training Post-Stroke
Source: ClinicalTrials.gov · Last updated 8 Apr 2026
Brief summary (registry, in English)
Approximately 15,000 Veterans are hospitalized for stroke each year with new cases costing an estimated $111 million for acute inpatient, $75 million for post-acute inpatient, and $88 million for follow-up care over 6 months post-stroke. The investigators have previously established the effectiveness of a backward walking training program to improve gait and balance in post-stroke Veterans. To best serve Veterans in this era of personalized medicine, there is a current need to determine the appropriate training dose as well as which post-stroke Veterans would most benefit. This study addresses both needs as it will 1) test responses to two different doses (18 vs. 27 sessions) of backward walking training and 2) assess brain activity, measured by magnetic resonance imaging, before and after training intervention to determine its ability to predict rehabilitation response as well as brain mechanisms of behavioral change.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 48 (estimated)
- First submitted
- 9 Jun 2021
- Start date
- 8 Nov 2021
- Primary completion date
- 30 Sept 2026
- Lead sponsor
- VA Office of Research and Development
- Diseases
- Stroke
- NCT number
- NCT04928482
What you commit to
- Study type: Interventional
- Planned participants: 48
- From 8 Nov 2021 to the primary completion date, 30 Sept 2026
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Receiving physical therapy services for mobility and/or gait
Other illness
- Presence of neurological condition other than stroke
- Serious cardiac conditions (hospitalization for myocardial infarction or heart surgery within 3 months, history of congestive heart failure, documented serious and unstable cardiac arrhythmias, hypertrophic cardiomyopathy, severe aortic stenosis, angina or dyspnea at rest or during activities of daily living)
- Anyone meeting New York Heart Association criteria for Class 3 or Class 4 heart disease will be excluded
- Severe hypertension with systolic greater than 200 mmHg and diastolic greater than 110 mmHg at rest
Other
- Severe arthritis or orthopedic problems that limit passive ranges of motion of lower extremity (knee flexion contracture of -10 degrees, knee flexion ROM \< 90 degrees, hip flexion contracture \> 25 degrees, and ankle plantar flexion contracture \> 15 degrees)
- Pain upon ambulation
- Living in a skilled nursing facility
- Any MRI contraindication, including but not limited to the presence of metal, MR sensitive implanted medical devices, or claustrophobia
Who the study is looking for
- Berg Balance Scale \< 45
- Self-selected 10 meter gait speed \< 0.8 m/s
- Diagnosis of unilateral stroke
- \> 2 months \< 4 months post-stroke
- Able to ambulate at least 10 feet with maximum 1 person assist
- Medically stable
Age in the registry: 18 years to 90 years · Sex: All · Does not accept healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| North Florida/South Georgia Veterans Health System, Gainesville, FL Coordinator of this site? Confirm its status | Gainesville | United States | Recruiting |
| Brooks Rehabilitation Coordinator of this site? Confirm its status | Jacksonville | United States | Not yet recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.