High Dose Omeprazole in Patients With Pancreatic Cancer

Other illness

• Patients with pancreatic malignant tumor histologically confirmed as neuroendocrine or any other type of malignancies
• Known hypersensitivity to any component of the formulation or substituted benzimidazoles
• Any clinically significant and/or uncontrolled cardiac-related abnormality that would compromise patient safety or the outcome of the study
• Medical condition that might affect the absorption of study medications in the opinion of the investigator.

Lab values

• Any other clinically significant laboratory abnormality that would compromise patient safety or the outcome of the study

Other

• Positive pregnancy test, pregnant, or breastfeeding

• Newly diagnosed exocrine pancreatic cancer with either pathology, histology, or radiology imaging documented as adenocarcinoma
• Patient is a candidate for surgical resection of pancreatic cancer
• ≥ 18 years old at the time of informed consent
• ECOG Performance Status 0-2
• Patients with or without neoadjuvant chemotherapy will be eligible
• Ability to provide written informed consent and HIPAA authorization
• Women of childbearing potential definition must have a negative pregnancy test within 14 days of registration. All women (regardless of sexual orientation, having undergone a tubal ligation, or remaining celibate by choice) are considered to have childbearing potential unless they meet one of the following criteria:
• Prior hysterectomy or bilateral oophorectomy;
• Has not had menses at any time in the preceding 24 consecutive months
• Candidate for surgery per standard of care of per surgeon's discretion