NCT04932447Active, not recruiting
Breathing Training for Improving Cardiovascular Health in Older Adults With Sleep Apnea
Time-efficient Inspiratory Muscle Strength Training for Improving Blood Pressure and Vascular Function in Older Adults With Sleep Disordered Breathing
Source: ClinicalTrials.gov · Last updated 8 Oct 2025
Brief summary (registry, in English)
This clinical research study will investigate the effects of respiratory strength training on blood pressure and cardiovascular health in adults who are 50 years of age and older and have been diagnosed with moderate or severe obstructive sleep apnea.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 122 (estimated)
- First submitted
- 27 Apr 2021
- Start date
- 1 Sept 2021
- Primary completion date
- 30 Jun 2026
- Lead sponsor
- University of Arizona
- Diseases
- High blood pressure
- NCT number
- NCT04932447
What you commit to
- Study type: Interventional
- Planned participants: 122
- From 1 Sept 2021 to the primary completion date, 30 Jun 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Alcohol or illegal drug dependence or abuse
- Uncontrolled thyroid disease or change in thyroid medication within previous 3 months
Other illness
- Chronic overt and poorly controlled medical condition (e.g., diabetes, chronic kidney disease, cancer, congestive heart failure)
Age
- Age \<50
Other
- AHI \<15
- Individuals with central or mixed sleep disordered breathing
- Severe hypoxemia (\<80% for \>10% of recording time) during sleep
- ESS \>15
- SBP ≥160 or DBP ≥120
- Current smoker
- Cheyne-Stokes Respiration
- Regular/vigorous aerobic exercise (\> 4 bouts/week, \>30 min/bout at high workload \>6 METS)
Who the study is looking for
- Age 50 and older
- Ability to understand study procedures and to comply with them for the entire length of the study
- Ability to provide informed consent;
- Willing to accept random assignment to condition
- AHI ≥15
- Individuals with who are unwilling or unable to adhere to CPAP
- Individuals who are adherent to CPAP therapy (i.e., 4 hours/night on 70%/nights over 30 days in the first 3 months of initial usage)
- Individuals who are adherent to mandibular advancement device each night
- Above-normal SBP (i.e., SBP ≥120)
- BMI ≤40 kg/m2
- Weight stable in the prior 3 months (\<3.0 kg weight change) and willing to remain weight stable throughout the study
- No change in anti-hypertensive medications or other medications (prescription or dosing) in the prior 3 months and willingness to maintain current medication regimen throughout the study
- Absence of unstable clinical disease as determined by medical history, physical examination, and blood chemistries
- Total cholesterol \<240 mg/dL
- Fasting plasma glucose \<300 mg/dL
Age in the registry: 50 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Arizona Respiratory and Neurophysiology Laboratory Coordinator of this site? Confirm its status | Tucson | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.