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NCT04936035CompletedPhase 2

A Study to Evaluate Efficacy and Safety of ALN-AGT01 in Patients With Mild To-Moderate Hypertension

A Randomized, Double-blind, Placebo-Controlled, Dose-Ranging Multicenter Study to Evaluate the Efficacy and Safety of ALN-AGT01 in Patients With Mild-to-Moderate Hypertension

Source: ClinicalTrials.gov · Last updated 23 Dec 2025

Brief summary (registry, in English)

The purpose of this study is to evaluate the effect of ALN-AGT01 on systolic and diastolic blood pressure and to characterize the pharmacodynamic (PD) effects and safety of ALN-AGT01.

Status (registry)
Completed
Phase (registry)
Phase 2
Study type
Interventional
Enrollment
394 (actual)
First submitted
14 Jun 2021
Start date
7 Jul 2021
Primary completion date
4 Apr 2023
Lead sponsor
Alnylam Pharmaceuticals
NCT number
NCT04936035
EudraCT number
2021-001248-82

What you commit to

  • Study type: Interventional · Phase 2
  • Participants enrolled: 394
  • From 7 Jul 2021 to the primary completion date, 4 Apr 2023
  • 68 sites in 5 countries
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • Received an investigational agent within the last 30 days
  • History of any cardiovascular event within 6 months prior to randomization

Other illness

  • Secondary hypertension, orthostatic hypotension
  • Type 1 diabetes mellitus, poorly controlled Type 2 diabetes mellitus, newly diagnosed Type 2 diabetes mellitus
  • History of intolerance to SC injection(s)

Lab values

  • Alanine aminotransferase (ALT) or aspartate aminotransferase (AST) \>2× upper limit of normal (ULN)
  • Elevated potassium \>5 mEq/L
  • Estimated glomerular filtration rate (eGFR) of ≤30 mL/min/1.73m\^2

Who the study is looking for

  • Daytime mean SBP ≥135 mmHg and ≤160 mmHg by ABPM, without antihypertensive medication

Age in the registry: 18 years to 75 years · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (68)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
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BramptonCanadaUnknown status
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ChicoutimiCanadaUnknown status
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MirabelCanadaUnknown status
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MontrealCanadaUnknown status
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New MinasCanadaUnknown status
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QuébecCanadaUnknown status
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Red DeerCanadaUnknown status
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TorontoCanadaUnknown status
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Trois-RivièresCanadaUnknown status
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VictoriavilleCanadaUnknown status
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GlasgowUnited KingdomUnknown status
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HexhamUnited KingdomUnknown status
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LondonUnited KingdomUnknown status
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ManchesterUnited KingdomUnknown status
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BayamónPuerto RicoUnknown status
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PoncePuerto RicoUnknown status
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San JuanPuerto RicoUnknown status
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Ivano-FrankivskUkraineUnknown status
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KharkivUkraineUnknown status
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OdesaUkraineUnknown status
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UzhhorodUkraineUnknown status
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AcworthUnited StatesUnknown status
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BaltimoreUnited StatesUnknown status
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Beverly HillsUnited StatesUnknown status
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BirminghamUnited StatesUnknown status
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BurkeUnited StatesUnknown status
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Cedar ParkUnited StatesUnknown status
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ChampaignUnited StatesUnknown status
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ClearwaterUnited StatesUnknown status
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ColumbusUnited StatesUnknown status
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Coral GablesUnited StatesUnknown status
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FayettevilleUnited StatesUnknown status
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Fleming IslandUnited StatesUnknown status
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GreensboroUnited StatesUnknown status
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GreenvilleUnited StatesUnknown status
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HollywoodUnited StatesUnknown status
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HoustonUnited StatesUnknown status
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InvernessUnited StatesUnknown status
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JacksonUnited StatesUnknown status
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JacksonvilleUnited StatesUnknown status
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Jefferson CityUnited StatesUnknown status
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Lake CharlesUnited StatesUnknown status
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La MesaUnited StatesUnknown status
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Las VegasUnited StatesUnknown status
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Los AngelesUnited StatesUnknown status
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MaconUnited StatesUnknown status
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MagnoliaUnited StatesUnknown status
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MedfordUnited StatesUnknown status
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MemphisUnited StatesUnknown status
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MiamiUnited StatesUnknown status
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NaplesUnited StatesUnknown status
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New OrleansUnited StatesUnknown status
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New YorkUnited StatesUnknown status
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OrlandoUnited StatesUnknown status
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PearlandUnited StatesUnknown status
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PrairievilleUnited StatesUnknown status
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San AntonioUnited StatesUnknown status
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San DiegoUnited StatesUnknown status
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South GateUnited StatesUnknown status
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StephenvilleUnited StatesUnknown status
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TempeUnited StatesUnknown status
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The BronxUnited StatesUnknown status
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TomballUnited StatesUnknown status
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ValparaisoUnited StatesUnknown status
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VistaUnited StatesUnknown status
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WacoUnited StatesUnknown status
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Washington D.C.United StatesUnknown status
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West Des MoinesUnited StatesUnknown status

This page is information, not medical advice. Discuss any trial with your doctor.