Segmentectomy Versus Lobectomy for Lung Adenocarcinoma ≤ 2cm

Prior treatment

• Prior chemotherapy, radiation therapy or any other therapies were performed; 12 participated in other tumors within three months of relevant clinical subjects;

Other illness

• Patients with other malignant tumors;

Lab values

• Patients with severe damage to heart, liver and kidney function (grade 3 \~ 4, ALT and/or AST over 3 times the normal upper limit, Cr over the normal upper limit);

Other

• Radiological pure ground glass nodules (consolidation to tumor ratio \< 0.25);
• The nodule is close to the lung hilus and is unable to perform segmentectomy;
• Intraoperative frozen section confirmed with micropapillary and solid subtype positive (\> 5%);
• Intraoperative frozen section confirmed adenocarcinoma in situ and minimally invasive adenocarcinoma;
• Preoperative imaging examination or EBUS indicated lymph node positive metastasis;
• Preoperative imaging examination revealed distant metastasis;
• Pregnant, planned pregnancy and lactating female patients (urine HCG\>2500IU/L is diagnosed as early pregnancy);
• Those who have participated in other tumor-related clinical trials within three months;
• Those are not suitable for participating in trials according to investigator's assessment.

• Patient aged 20-79 years old, both male or female;
• Tumor size \<= 2cm on preoperative CT scan;
• Peripheral solitary nodule or the associated lesion is MIA or less invasive lesion;
• Preoperative CT indicated that the nodules were non-pure glass nodules (consolidation to tumor ratio \>= 0.25);
• Intraoperative frozen section confirmed invasive lung adenocarcinoma with micropapillary and solid subtype negative (\<= 5%);
• Intraoperative frozen section indicated the resection margins was free of tumor cells;
• Lung function could withstand both lung segmentectomy and lobectomy (FEV1 \> 1.5L or FEV1% \>= 60%);
• Eastern Cooperative Oncology Group, 0 to 2;
• Volunteer to participate the trial and sign the informed consent, able to comply with the follow-up plan and other program requirements.