NCT04940663Recruiting
Neurobehavioral Mechanisms of Social Isolation and Loneliness in Serious Mental Illness
Source: ClinicalTrials.gov · Last updated 16 Jul 2026
Brief summary (registry, in English)
The proposed research will test the hypothesis that objective social isolation and loneliness are linked to neurobehavioral mechanisms involved in social perception and motivation in individuals with and without serious mental illness. Moreover, it will investigate the specific dynamic interactions among these experiences in daily life and how they, and their neurobehavioral predictors, are linked to day-to-day functioning. The findings of this project could provide novel targets for therapeutics aimed at improving functioning and overall quality of life in individuals with serious mental illnesses, as well as quantitative phenotypes for use in early detection efforts.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 120 (estimated)
- First submitted
- 18 Jun 2021
- Start date
- 13 Jul 2022
- Primary completion date
- Oct 2026
- Lead sponsor
- Massachusetts General Hospital
- Diseases
- Schizophrenia
- NCT number
- NCT04940663
What you commit to
- Study type: Interventional
- Planned participants: 120
- From 13 Jul 2022 to the primary completion date, Oct 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- A recent change in medication, or an acute symptom presentation
Other illness
- Any neurological disorder or current substance use disorder (during the past 6 months)
- Standard exclusion criteria for participation in an MRI scan (e.g., presence of metal in the body, claustrophobia, a history of head trauma).
Other
- Not proficient in English
Who the study is looking for
- 18-55 years old
- Experienced a psychotic disorder or mood disorder
Age in the registry: 18 years to 55 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Massachusetts General Hospital Coordinator of this site? Confirm its status | Charlestown | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.