NCT04941768Completed
An Observational Study to Evaluate the Efficacy and Safety of Avelumab + Axitinib Combination in Participants With aRCC (AVION)
Real-world Evaluation of Efficacy and Safety With Avelumab (BAVENCIO®) + Axitinib (INLYTA®) in Patients With aRCC in Multiple EU Countries (AVION)
Source: ClinicalTrials.gov · Last updated 16 Jun 2026
Brief summary (registry, in English)
The main purpose of this study is to expand knowledge on the effectiveness of Avelumab intravenous infusion in combination with Axitinib as the first-line therapy in participants with advanced renal-cell carcinoma (aRCC) in addition to the safety and tolerability under routine conditions of daily clinical practice.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 105 (actual)
- First submitted
- 23 Jun 2021
- Start date
- 9 Aug 2021
- Primary completion date
- 8 Aug 2024
- Lead sponsor
- Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany
- Diseases
- Kidney cancer
- NCT number
- NCT04941768
What you commit to
- Study type: Observational
- Participants enrolled: 105
- From 9 Aug 2021 to the primary completion date, 8 Aug 2024
- 61 sites in 4 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Participants who have participated in any interventional clinical study of a drug or device within 28 days prior to the start of Avelumab plus Axitinib
Other
- Participants with contraindications for Avelumab or Axitinib according to the approved SmPC
Who the study is looking for
- Participants with the Eastern Cooperative Oncology Group (ECOG) performance status 0, 1, or 2
- Participants with a histologically confirmed diagnosis of RCC with any histological origin
- Participants with a locally advanced/metastatic disease (that is \[ie\], newly diagnosed Stage 4 RCC per American Joint Committee on Cancer) or has recurrent disease
- Participants has received 1 or 2 cycles of Avelumab plus Axitinib treatment as a first-line therapy according to the approved Summary of Product Characteristics (SmPC)
- Participants willing to sign the written informed consent form (ICF) to participate in this study
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (61)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Imelda Ziekenhuis Coordinator of this site? Confirm its status | Bonheiden | Belgium | Unknown status |
| AZ KLINA Coordinator of this site? Confirm its status | Brasschaat | Belgium | Unknown status |
| AZ Sint Jan Coordinator of this site? Confirm its status | Bruges | Belgium | Unknown status |
| Klinikum St. Marien Amberg Coordinator of this site? Confirm its status | Amberg | Germany | Unknown status |
| Klinikum Aschaffenburg Medizinische Klinik Coordinator of this site? Confirm its status | Aschaffenburg | Germany | Unknown status |
| Zentrum für urologische Onkologie Coordinator of this site? Confirm its status | Berlin | Germany | Unknown status |
| Biberach Coordinator of this site? Confirm its status | Biberach an der Riss | Germany | Unknown status |
| Evangelisches Klinikum Bethel Coordinator of this site? Confirm its status | Bielefeld | Germany | Unknown status |
| Evangelisches Krankenhaus Bielefeld Coordinator of this site? Confirm its status | Bielefeld | Germany | Unknown status |
| Urologie im Schlosscarree Coordinator of this site? Confirm its status | Braunschweig | Germany | Unknown status |
| DONAUISAR Klinikum Deggendorf Coordinator of this site? Confirm its status | Deggendorf | Germany | Unknown status |
| Urologische Gemeinschaftspraxis Coordinator of this site? Confirm its status | Dresden | Germany | Unknown status |
| St. Georg Klinikum Eisenach gGmbH Coordinator of this site? Confirm its status | Eisenach | Germany | Unknown status |
| Universitätsklinikum Erlangen Coordinator of this site? Confirm its status | Erlangen | Germany | Unknown status |
| Universitaetsklinikum Essen Uroonkologie Coordinator of this site? Confirm its status | Essen | Germany | Unknown status |
| Klinikum Friedrichshafen GmbH daVinci® -Zentrum Bodensee Coordinator of this site? Confirm its status | Friedrichshafen | Germany | Unknown status |
| Onkologische SP Praxis Fürth Coordinator of this site? Confirm its status | Fürth | Germany | Unknown status |
| Onkologische GP Dres. Wilke/Wagner/Petzoldt Coordinator of this site? Confirm its status | Fürth | Germany | Unknown status |
| MVZ Onkologische Kooperation Harz GbR Coordinator of this site? Confirm its status | Goslar | Germany | Unknown status |
| Praxis Dr. Maas Coordinator of this site? Confirm its status | Halberstadt | Germany | Unknown status |
| Universitätsklinikum Hamburg-Eppendorf Coordinator of this site? Confirm its status | Hamburg | Germany | Unknown status |
| Medizinische Hochschule Hannover Coordinator of this site? Confirm its status | Hanover | Germany | Unknown status |
| Vinzenzkrankenhaus Hannover Coordinator of this site? Confirm its status | Hanover | Germany | Unknown status |
| Praxis Kretz Coordinator of this site? Confirm its status | Heinsberg | Germany | Unknown status |
| Universitätskinderklinik Jena Coordinator of this site? Confirm its status | Jena | Germany | Unknown status |
| Urologische Praxis Dr. Ralf Eckert Coordinator of this site? Confirm its status | L.-Eisleben | Germany | Unknown status |
| Universitatsklinik Schleswig-Holstein Coordinator of this site? Confirm its status | Lübeck | Germany | Unknown status |
| Urologische Praxis Dipl.-Med. Susanne Kloß Coordinator of this site? Confirm its status | Luckenwalde | Germany | Unknown status |
| Schwerpunktpraxis für Hämatologie und Onkologie Coordinator of this site? Confirm its status | Magdeburg | Germany | Unknown status |
| Johannes Wesling Klinikum Minden der Mühlenkreiskliniken (AöR) Coordinator of this site? Confirm its status | Minden | Germany | Unknown status |
| Uniklinikum Münster Coordinator of this site? Confirm its status | Münster | Germany | Unknown status |
| University of Munster Coordinator of this site? Confirm its status | Münster | Germany | Unknown status |
| Paracelsus Klinik Osnabrück Coordinator of this site? Confirm its status | Osnabrück | Germany | Unknown status |
| Klinikum Osnabrück GmbH Coordinator of this site? Confirm its status | Osnabrück | Germany | Unknown status |
| Marienhospital Osnabrück - Standort Natruper Holz Coordinator of this site? Confirm its status | Osnabrück | Germany | Unknown status |
| medius Klinik Ostfildern-Ruit Coordinator of this site? Confirm its status | Ostfildren | Germany | Unknown status |
| Wissenschaftskontor Nord GmbH & Co. KG Coordinator of this site? Confirm its status | Rostock | Germany | Unknown status |
| GPR Klinikum Rüsselsheimg GmbH Coordinator of this site? Confirm its status | Rüsselsheim am Main | Germany | Unknown status |
| SRH Kliniken Landkreis Sigmaringen (DEU) Coordinator of this site? Confirm its status | Sigmaringen | Germany | Unknown status |
| Hämatologie und Onkologie Stolberg Coordinator of this site? Confirm its status | Stolberg | Germany | Unknown status |
| Praxis Troisdorf Coordinator of this site? Confirm its status | Troisdorf | Germany | Unknown status |
| Medizinische Studiengesellschaft NORD-WEST GmbH Coordinator of this site? Confirm its status | Westerstede | Germany | Unknown status |
| Lahn-Dill-Kliniken GmbH Coordinator of this site? Confirm its status | Wetzlar | Germany | Unknown status |
| General Hospital of Athens "G. Gennimatas" Coordinator of this site? Confirm its status | Athens | Greece | Unknown status |
| University Hospital of Athens Sotiria Coordinator of this site? Confirm its status | Athens | Greece | Unknown status |
| Henry Dunant Hospital Center Coordinator of this site? Confirm its status | Athens | Greece | Unknown status |
| Gen. Hos. "Alexandra" Coordinator of this site? Confirm its status | Athens | Greece | Unknown status |
| Attikon Hospital Coordinator of this site? Confirm its status | Attiki | Greece | Unknown status |
| Attikon Coordinator of this site? Confirm its status | Chaïdári | Greece | Unknown status |
| General Hospital "Venizelio" Coordinator of this site? Confirm its status | Heraklion | Greece | Unknown status |
| University Hospital of Ioannina Coordinator of this site? Confirm its status | Ioannina | Greece | Unknown status |
| Kavala General Hospital Coordinator of this site? Confirm its status | Kavala | Greece | Unknown status |
| University Hospital of Larissa Coordinator of this site? Confirm its status | Larissa | Greece | Unknown status |
| General Hospital of Patras "o Agios Andreas" Coordinator of this site? Confirm its status | Pátrai | Greece | Unknown status |
| Metaxa Hospital Coordinator of this site? Confirm its status | Piraeus | Greece | Unknown status |
| Metropolitan Hospital Greece Coordinator of this site? Confirm its status | Piraeus | Greece | Unknown status |
| Agios Loukas Hospital Coordinator of this site? Confirm its status | Thessaloniki | Greece | Unknown status |
| Saint Luke Hospital Coordinator of this site? Confirm its status | Thessaloniki | Greece | Unknown status |
| Papageorgiou Hospital Coordinator of this site? Confirm its status | Thessaloniki | Greece | Unknown status |
| Bioclinic (GRC) Coordinator of this site? Confirm its status | Thessaloniki | Greece | Unknown status |
| Regional Oncology Dispensary - Irkutsk Coordinator of this site? Confirm its status | Irkutsk | Russia | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.