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NCT04941768Completed

An Observational Study to Evaluate the Efficacy and Safety of Avelumab + Axitinib Combination in Participants With aRCC (AVION)

Real-world Evaluation of Efficacy and Safety With Avelumab (BAVENCIO®) + Axitinib (INLYTA®) in Patients With aRCC in Multiple EU Countries (AVION)

Source: ClinicalTrials.gov · Last updated 16 Jun 2026

Brief summary (registry, in English)

The main purpose of this study is to expand knowledge on the effectiveness of Avelumab intravenous infusion in combination with Axitinib as the first-line therapy in participants with advanced renal-cell carcinoma (aRCC) in addition to the safety and tolerability under routine conditions of daily clinical practice.

Status (registry)
Completed
Study type
Observational
Enrollment
105 (actual)
First submitted
23 Jun 2021
Start date
9 Aug 2021
Primary completion date
8 Aug 2024
Lead sponsor
Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany
NCT number
NCT04941768

What you commit to

  • Study type: Observational
  • Participants enrolled: 105
  • From 9 Aug 2021 to the primary completion date, 8 Aug 2024
  • 61 sites in 4 countries
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • Participants who have participated in any interventional clinical study of a drug or device within 28 days prior to the start of Avelumab plus Axitinib

Other

  • Participants with contraindications for Avelumab or Axitinib according to the approved SmPC

Who the study is looking for

  • Participants with the Eastern Cooperative Oncology Group (ECOG) performance status 0, 1, or 2
  • Participants with a histologically confirmed diagnosis of RCC with any histological origin
  • Participants with a locally advanced/metastatic disease (that is \[ie\], newly diagnosed Stage 4 RCC per American Joint Committee on Cancer) or has recurrent disease
  • Participants has received 1 or 2 cycles of Avelumab plus Axitinib treatment as a first-line therapy according to the approved Summary of Product Characteristics (SmPC)
  • Participants willing to sign the written informed consent form (ICF) to participate in this study

Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (61)

Sites in registry order. Save your city in your profile to sort them by distance.

SiteCityCountrySite status
Imelda Ziekenhuis
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BonheidenBelgiumUnknown status
AZ KLINA
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BrasschaatBelgiumUnknown status
AZ Sint Jan
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BrugesBelgiumUnknown status
Klinikum St. Marien Amberg
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AmbergGermanyUnknown status
Klinikum Aschaffenburg Medizinische Klinik
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AschaffenburgGermanyUnknown status
Zentrum für urologische Onkologie
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BerlinGermanyUnknown status
Biberach
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Biberach an der RissGermanyUnknown status
Evangelisches Klinikum Bethel
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BielefeldGermanyUnknown status
Evangelisches Krankenhaus Bielefeld
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BielefeldGermanyUnknown status
Urologie im Schlosscarree
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BraunschweigGermanyUnknown status
DONAUISAR Klinikum Deggendorf
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DeggendorfGermanyUnknown status
Urologische Gemeinschaftspraxis
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DresdenGermanyUnknown status
St. Georg Klinikum Eisenach gGmbH
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EisenachGermanyUnknown status
Universitätsklinikum Erlangen
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ErlangenGermanyUnknown status
Universitaetsklinikum Essen Uroonkologie
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EssenGermanyUnknown status
Klinikum Friedrichshafen GmbH daVinci® -Zentrum Bodensee
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FriedrichshafenGermanyUnknown status
Onkologische SP Praxis Fürth
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FürthGermanyUnknown status
Onkologische GP Dres. Wilke/Wagner/Petzoldt
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FürthGermanyUnknown status
MVZ Onkologische Kooperation Harz GbR
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GoslarGermanyUnknown status
Praxis Dr. Maas
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HalberstadtGermanyUnknown status
Universitätsklinikum Hamburg-Eppendorf
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HamburgGermanyUnknown status
Medizinische Hochschule Hannover
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HanoverGermanyUnknown status
Vinzenzkrankenhaus Hannover
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HanoverGermanyUnknown status
Praxis Kretz
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HeinsbergGermanyUnknown status
Universitätskinderklinik Jena
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JenaGermanyUnknown status
Urologische Praxis Dr. Ralf Eckert
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L.-EislebenGermanyUnknown status
Universitatsklinik Schleswig-Holstein
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LübeckGermanyUnknown status
Urologische Praxis Dipl.-Med. Susanne Kloß
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LuckenwaldeGermanyUnknown status
Schwerpunktpraxis für Hämatologie und Onkologie
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MagdeburgGermanyUnknown status
Johannes Wesling Klinikum Minden der Mühlenkreiskliniken (AöR)
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MindenGermanyUnknown status
Uniklinikum Münster
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MünsterGermanyUnknown status
University of Munster
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MünsterGermanyUnknown status
Paracelsus Klinik Osnabrück
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OsnabrückGermanyUnknown status
Klinikum Osnabrück GmbH
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OsnabrückGermanyUnknown status
Marienhospital Osnabrück - Standort Natruper Holz
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OsnabrückGermanyUnknown status
medius Klinik Ostfildern-Ruit
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OstfildrenGermanyUnknown status
Wissenschaftskontor Nord GmbH & Co. KG
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RostockGermanyUnknown status
GPR Klinikum Rüsselsheimg GmbH
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Rüsselsheim am MainGermanyUnknown status
SRH Kliniken Landkreis Sigmaringen (DEU)
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SigmaringenGermanyUnknown status
Hämatologie und Onkologie Stolberg
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StolbergGermanyUnknown status
Praxis Troisdorf
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TroisdorfGermanyUnknown status
Medizinische Studiengesellschaft NORD-WEST GmbH
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WesterstedeGermanyUnknown status
Lahn-Dill-Kliniken GmbH
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WetzlarGermanyUnknown status
General Hospital of Athens "G. Gennimatas"
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AthensGreeceUnknown status
University Hospital of Athens Sotiria
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AthensGreeceUnknown status
Henry Dunant Hospital Center
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AthensGreeceUnknown status
Gen. Hos. "Alexandra"
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AthensGreeceUnknown status
Attikon Hospital
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AttikiGreeceUnknown status
Attikon
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ChaïdáriGreeceUnknown status
General Hospital "Venizelio"
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HeraklionGreeceUnknown status
University Hospital of Ioannina
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IoanninaGreeceUnknown status
Kavala General Hospital
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KavalaGreeceUnknown status
University Hospital of Larissa
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LarissaGreeceUnknown status
General Hospital of Patras "o Agios Andreas"
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PátraiGreeceUnknown status
Metaxa Hospital
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PiraeusGreeceUnknown status
Metropolitan Hospital Greece
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PiraeusGreeceUnknown status
Agios Loukas Hospital
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ThessalonikiGreeceUnknown status
Saint Luke Hospital
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ThessalonikiGreeceUnknown status
Papageorgiou Hospital
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ThessalonikiGreeceUnknown status
Bioclinic (GRC)
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ThessalonikiGreeceUnknown status
Regional Oncology Dispensary - Irkutsk
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IrkutskRussiaUnknown status

This page is information, not medical advice. Discuss any trial with your doctor.