NCT04947657Recruiting
The CoAGulation Biomarkers and Atrial Fibrillation (COAG-AF) Pilot Study
Correlation Of CoAGulation Biomarkers and Atrial Fibrillation Burden in Patients Post Catheter Ablation: the COAG-AF Pilot Study
Source: ClinicalTrials.gov · Last updated 5 Mar 2026
Brief summary (registry, in English)
The aim of the Correlation Of CoAGulation-Atrial Fibrillation (COAG-AF) study is to prove that an increase in pro-thrombotic biomarkers in AF is associated with an increase in AF burden. Secondary objectives of the study are the following: * To investigate the impact of catheter ablation on serum pro-thrombotic biomarkers in patients with AF. * To correlate coagulation biomarkers with imaging features such as, the degree of fibrosis found on Late Gadolinium Enhancement Magnetic Resonance Imaging (LGE-MRI) scans, which is a part of standard of care. * To determine baseline values of coagulation and pro-thrombotic biomarkers in the AF population and compare those baseline values with the general population values. * To compare central and peripheral thrombotic biomarkers in patients with atrial fibrillation.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 20 (estimated)
- First submitted
- 23 Jun 2021
- Start date
- 22 Sept 2021
- Primary completion date
- Dec 2027
- Lead sponsor
- Tulane University
- Diseases
- Atrial fibrillation
- NCT number
- NCT04947657
What you commit to
- Study type: Observational
- Planned participants: 20
- From 22 Sept 2021 to the primary completion date, Dec 2027
- 3 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Patients with coagulation disorders such as, von Willebrand disease, hemophilia, Immune Thrombocytopenic Purpura, etc.
- Do not plan to continue practicing two acceptable methods of birth control throughout the trial (highly effective methods of birth control are defined as those, used alone or in combination, that result in a low failure rate i.e. less than 1% per year when used consistently and correctly).
- Any health-related gadolinium/MRI contraindications (e.g. allergy to gadolinium, pacemakers, Implantable Cardioverter Defibrillators (ICD's), other devices/implants contraindicated for use of MRI, etc.)
- Patients who have a known terminal illness with a prognosis less than 12 months at the time of the informed consent process.
Lab values
- Patient with diagnosed acute or chronic severe kidney disease or with a low glomerular filtration rate (GFR), \<30 mL per minute per 1.73 m2
Other
- Patients who are pregnant or breast-feeding or plan to become pregnant during the study period.
- Are not surgically sterile.
- Are of childbearing potential and are unwilling to practice two acceptable methods of birth control.
- Patients with mental and/or physical ailments which may prohibit them from actively participating in the study.
- Planned cardiovascular intervention.
- Patients who cannot read, speak, and/or understand English.
- Patients with cognitive impairments who are unable to give informed consent.
Who the study is looking for
- Patients, male or female and older than 18 years of age.
- Patients diagnosed with persistent or paroxysmal AF.
- Patients that are undergoing catheter ablation at Tulane University Medical Center.
- Patients that had a cardiac MRI prescribed by their physician as part of their standard of care.
Age in the registry: 18 years to 120 years · Sex: All · Does not accept healthy volunteers
Sites (3)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University Medical Center Coordinator of this site? Confirm its status | New Orleans | United States | Recruiting |
| East Jefferson General Hospital Coordinator of this site? Confirm its status | New Orleans | United States | Recruiting |
| Tulane Doctors - Speciality Care - Napoleon Coordinator of this site? Confirm its status | New Orleans | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.