Assessing the Efficacy of Sirolimus in Patients With COVID-19 Pneumonia for Prevention of Post-COVID Fibrosis

Prior treatment

• Known diagnosis of previous pulmonary fibrosis or an interstitial lung disease.
• Pregnant or lactating females. Females of child bearing potential are required to have a negative pregnancy test prior to treatment and practice abstinence or prevent pregnancy by at least a barrier method of birth control.
• Investigational therapy for any indication within 28 days prior to treatment.
• Current treatment with any drugs that are strong inhibitors of CYP3A4.

Other illness

• Clinical features or known diagnosis of malignancy or active non-COVID-19 infection, including untreated latent tuberculosis.
• History of unstable or deteriorating cardiac disease (including myocardial infarction, coronary artery bypass surgery or angioplasty within the past 6 months, congestive heart failure requiring hospitalization within the past 6 months, or uncontrolled arrhythmia.
• Known history of hypersensitivity to sirolimus.
• History of unstable or deteriorating neurologic disease (including TIAs or stroke).

Other

• Tofacitinib
• Clarithromycin
• Telithromycin
• Nefazodone
• Itraconazole
• Ketoconazole
• Atazanavir
• Darunavir
• Indinavir
• Lopinavir
• Nelfinavir
• Ritonavir
• Saquinavir
• Tipranavir.
• Inability or unwillingness to comply with the requirements for the trial.

• Adults ≥ 18 years of age
• Approval from the patient's primary inpatient service
• Hospitalized
• Diagnosed with COVID-19 pneumonia
• Positive test for active SARS-CoV-2 infection
• Requiring supplemental oxygen ≥ 5LNC or ≥ 40% FiO2.
• Chest computed tomography (CT) at admission with \< 10% pulmonary fibrosis
• Ability to provide written informed consent on the part of the subject or, in the absence of decisional capacity of the subject, an appropriate surrogate (e.g. a legally authorized representative).