NCT04948866Completed
Palliative Care for Persons With Late-stage Alzheimer's and Related Dementias and Their Caregivers
Source: ClinicalTrials.gov · Last updated 16 Dec 2025
Brief summary (registry, in English)
Millions of Americans have late-stage Alzheimer's and related dementias (ADRD), causing suffering due to loss of awareness of self and family, progressive dependency, physical and neuropsychiatric symptoms, and physical, emotional and financial strain for caregivers. Investigators now propose a multi-site randomized clinical trial of the ADRD Palliative Care (ADRD-PC) program for persons with late-stage ADRD and their family caregivers, triggered during hospitalization. Investigators aim to learn if this program of dementia-specific palliative care, standardized caregiver education, and transitional care is effective to reduce burdensome hospital transfers, improve symptom treatment and control, augment supportive services, and reduce nursing home transitions for patients, and to improve caregiver outcomes of communication, shared decision-making and distress.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 884 (actual)
- First submitted
- 23 Jun 2021
- Start date
- 26 Jul 2021
- Primary completion date
- 1 Feb 2025
- Lead sponsor
- University of North Carolina, Chapel Hill
- Diseases
- Lewy body dementia, Alzheimer disease
- NCT number
- NCT04948866
What you commit to
- Study type: Interventional
- Participants enrolled: 884
- From 26 Jul 2021 to the primary completion date, 1 Feb 2025
- 5 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other
- Dyads will be excluded if
- the LAR is not a family caregiver
- the patient currently receives palliative care or hospice
- patient or caregiver would be unduly stressed
- dyad is not successfully randomized.
Who the study is looking for
- People with ADRD Inclusion Criteria:
- aged 55 or older
- hospitalized
- have a physician-confirmed diagnosis of ADRD
- staged GDS 6 or 7; or GDS 5 with additional co-morbidity defined by Charlson Comorbidity Index scored 5 or higher
- Caregiver Inclusion Criteria:
- the adult (aged 18 or older) legally authorized representative (LAR) for healthcare and have capacity to serve in this role
- support the person with ADRD
- can complete interviews in English or Spanish.
Age in the registry: 55 years to - · Sex: All · Does not accept healthy volunteers
Sites (5)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Emory University Coordinator of this site? Confirm its status | Atlanta | United States | Unknown status |
| Massachusetts General Hospital Coordinator of this site? Confirm its status | Boston | United States | Unknown status |
| University of North Carolina at Chapel Hill Coordinator of this site? Confirm its status | Chapel Hill | United States | Unknown status |
| University of Colorado Denver Coordinator of this site? Confirm its status | Denver | United States | Unknown status |
| Indiana University Coordinator of this site? Confirm its status | Indianapolis | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.