NCT04953637Active, not recruiting
Physiotherapy and Deep Brain Stimulation in Parkinson's Disease
Combined Physiotherapy and Deep Brain Stimulation to Improve Independent Community Mobility in Parkinson's Disease
Source: ClinicalTrials.gov · Last updated 22 Sept 2025
Brief summary (registry, in English)
Deep brain stimulation (DBS) is the most commonly performed surgical treatment for individuals with Parkinson's disease (PD). DBS typically works best to lessen motor symptoms such as stiffness, slowness, and tremor. Despite an overall improvement of these motor symptoms with DBS, past research failed to show an increase in community mobility and have often reported an increase in falling after surgery. The ability to move around on one's own is important for functional independence and improved quality of life. There is growing evidence supporting the positive effects of physiotherapy on individuals with PD. Gait and balance training, in particular, can improve mobility and also prevent falls. So far, no study has shown the effectiveness of rehabilitation in patients receiving DBS. The purpose of this study is to determine if DBS combined with physiotherapy is effective for improving safe independent mobility in individuals with PD, more so than with patients receiving DBS alone.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 60 (estimated)
- First submitted
- 21 Jun 2021
- Start date
- 15 Apr 2021
- Primary completion date
- 30 Nov 2025
- Lead sponsor
- University of Toronto
- Diseases
- Parkinson disease
- NCT number
- NCT04953637
What you commit to
- Study type: Interventional
- Planned participants: 60
- From 15 Apr 2021 to the primary completion date, 30 Nov 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Participants who are already receiving physiotherapy treatment (or that has been receiving it during the three months prior to enrollment) will be excluded from the study.
Other illness
- Participants will be excluded if they have ongoing orthopaedic conditions potentially impacting on global mobility.
Other
- Participants with severe cognitive deficits ((Montreal Cognitive Assessment (MoCA) score \<17).
Who the study is looking for
- PD patients who have been identified as candidates for DBS.
- Ability to give informed consent.
- Patients ages 18 years and older.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Movement Disorders Centre - Toronto Western Hospital Coordinator of this site? Confirm its status | Toronto | Canada | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.