NCT04959019Completed
Exercise for Memory Rehabilitation in Epilepsy
Source: ClinicalTrials.gov · Last updated 11 Mar 2026
Brief summary (registry, in English)
The purpose of this study is to determine how effective a 6-week exercise program is for improving memory compared to a no-intervention control group, investigate the brain changes that may be responsible for memory improvements, and determine if the memory benefits and brain changes are retained 6 weeks after completing the exercise intervention in people with Idiopathic generalized epilepsy (IGE).
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 71 (actual)
- First submitted
- 24 Jun 2021
- Start date
- 21 Jul 2021
- Primary completion date
- 18 Feb 2026
- Lead sponsor
- University of Alabama at Birmingham
- Diseases
- Epilepsy
- NCT number
- NCT04959019
What you commit to
- Study type: Interventional
- Participants enrolled: 71
- From 21 Jul 2021 to the primary completion date, 18 Feb 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- recent suicidal ideation in the last 3 months determined based on previous medical history
- concurrent participation in a different intervention study
- diseased or enlarged heart or blood vessels determined based on previous medical history
- high blood pressure that is not controlled by medications
Other illness
- underlying degenerative or metabolic disorders
- mental handicap (FSIQ\<80 if tested) or history of special education
- meeting the American Heart Association recommendation of physical activity in adults
Other
- abnormal general or neurological examination
- abnormal brain MRI
- pregnant or positive pregnancy test result on the day of the research session
- contraindication to an MRI scan at 3-Telsa
- abnormal physical examination in which study physician determines subject should not participate in the exercise intervention
Who the study is looking for
- males and females
- ages 18-65 years old
- speaks English fluently
- able to provide written informed consent
- have no contraindications to 3-Telsa MRI
- clinician-confirmed diagnosis of IGE (IGE includes epilepsy syndromes such as juvenile myoclonic epilepsy, juvenile absence epilepsy, childhood absence epilepsy, and generalized tonic-clonic seizures alone)
- relatively healthy with no comorbid medical conditions besides epilepsy
- normal pre-enrollment structural clinical MRI of the brain (if available)
- having less than the American Heart Association recommendation of physical activity in adults (at least 30 min moderate-intensity aerobic activity at least 5 days/week (150 min total), or at least 25 min vigorous aerobic activity at least 3 days/week (75 min total) and moderate-/high-intensity muscle strengthening activity at least 2 days/week)
Age in the registry: 18 years to 65 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Alabama at Birmingham Coordinator of this site? Confirm its status | Birmingham | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.