AcTIVE - ACid tranexamic or Terlipressin for Initial emergency treatment of mild to seVere hEmoptysis: a randomized Trial

Prior treatment

• Know previous cardiac arrhythmia (atrial fibrillation, atrial flutter..)
• Participation in another interventional study or being in the exclusion period at the end of a previous study

Other illness

• Known hypersensitivity to TXA or TER or one of its excipients

Lab values

• Contraindication for contrast agents injection (renal failure with creatinin clearance < 30ml/min, know allergy to contrast agents injection)
• Contraindication to TXA (including renal failure with creatinin clearance < 30mL/min) or TER therapy : acute myocardial infarction in the 6 past months, intrathecal injection in the 3 past months, seizure in the past 3 months

Other

• Need for mechanical ventilation
• Cystic fibrosis
• Pregnancy or breast feeding
• Patient under tutorship or / guardianship, and incapable to give informed consent

• Patients over 18 years, under 90 years
• Mild to severe hemoptysis that has been going on for less than 7 days
• Total expectorate blood ranging from 50 ml to 200 ml
• Admission in emergency department or ICU for less than 12 hours
• Social security affiliation
• Signed informed consent
• For child-bearing aged women, efficient contraception includes oral oestrogen-progestin, oral progestin, progestin implants and all types of intrauterine devices