NCT04967183Active, not recruiting
Polyprev: Study to Compare Fecal Immunochemical Test With Endoscopic Surveillance After Advanced Adenoma Resection in Fecal Immunochemical Test Colorectal Cancer Screening Programs.
Polyprev Study: Randomized, Multicenter, Controlled Trial Comparing Fecal Immunochemical Test With Endoscopic Surveillance After Advanced Adenoma Resection in Fecal Immunochemical Test Colorectal Cancer Screening Programs.
Source: ClinicalTrials.gov · Last updated 3 Sept 2026
Brief summary (registry, in English)
Colorectal cancer (CRC) screening programs have been implemented to reduce the burden of the disease. When an advanced colonic lesions is detected, it is recommended to perform endoscopic surveillance with different intervals between explorations. Although the reduction in CRC incidence, endoscopic surveillance is producing a considerable increase in the number of colonoscopies. However, participation in CRC screening programs based on the fecal immunochemical test (FIT) could be a non inferior alternative to endoscopic surveillance. Based on this hypothesis, the research group have designed a randomized clinical trial within the population CRC screening programs to compare FIT surveillance to endoscopic surveillance in patients with advanced lesions resected.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 3788 (estimated)
- First submitted
- 8 Jul 2021
- Start date
- 1 Jun 2022
- Primary completion date
- 12 Apr 2026
- Lead sponsor
- Fundacin Biomedica Galicia Sur
- Diseases
- Colorectal cancer
- NCT number
- NCT04967183
What you commit to
- Study type: Interventional
- Planned participants: 3788
- From 1 Jun 2022 to the primary completion date, 12 Apr 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Incomplete resection of baseline lesions.
Other illness
- Personal history of CRC.
- Serrated polyposis syndrome.
Other
- Colonic lesion ≥10mm resected without histological diagnosis.
- More than 10 adenomas in baseline colonoscopy.
- Two or more first-degree relatives with CRC.
- Hereditary predisposition to CRC.
- Relevant comorbidity with life expectancy inferior to 5 years.
- Colonoscopy with incomplete mucosal examination.
- Non-acceptance after reading the informed consent.
Who the study is looking for
- Individuals aged 50 to 65 years.
- Individuals with at least one advanced adenoma (tubulovillous or villous histology, high grade dysplasia or ≥ 10mm), and / or at least three non-advanced adenomas detected and resected completely within the population-based CRC screening program.
Age in the registry: 50 years to 65 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Complexo Hospitalario Universitario de Ourense Coordinator of this site? Confirm its status | Ourense | Spain | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.