NCT04971564Recruiting
Thrombo-inflammation Biomarkers Trial in Acute Cerebral Hypoxia
Thrombo-inflammation Biomarkers Trial in Acute Cerebral Hypoxia. A Case-control Trial Nested in a Cohort
Source: ClinicalTrials.gov · Last updated 22 Jan 2026
Brief summary (registry, in English)
The goal of this trial is to study, in three well-defined clinical situations responsible for cerebral hypoxia, the concentrations of biomarkers of thrombo-inflammation compared to a population of patients without cerebral hypoxia, and to study in patients with cerebral hypoxia the association between these concentrations and the clinical evolution.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 200 (estimated)
- First submitted
- 12 Jul 2021
- Start date
- 19 Mar 2024
- Primary completion date
- 22 Jun 2026
- Lead sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
- Diseases
- Stroke
- NCT number
- NCT04971564
What you commit to
- Study type: Observational
- Planned participants: 200
- From 19 Mar 2024 to the primary completion date, 22 Jun 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Patients diagnosed with an acute non-vascular neurological pathology (migraine, epilepsy, etc.).
Other
- Pre-existing functional and/or cognitive disability
- Patient under legal protection.
- Pregnant or breastfeeding woman.
- Patient with secondary haemorrhagic transformation.
- Secondary exclusion criteria :
- Patients with an ischaemic lesion visible on imaging, unrelated to large vessel occlusion and therefore ineligible for mechanical thrombectomy.
- TIA patients presenting an abnormality on follow-up imaging 24-48 hours after the initial imaging.
- Excluded patients will be replaced.
Who the study is looking for
- \- For cases, admitted within the first 36 hours of an acute neurological symptom related to :
- An ischaemic cerebrovascular accident (iCVA) eligible for a mechanical thrombectomy procedure,
- A subarachnoid haemorrhage (SAH, all aetiologies) : patient presenting with at least a modified Fisher scale 3 or 4,
- An intra-parenchymal haematoma (IPH) with greatest axis ≥ 20mm or with NIHSS on admission \>4.
- OR
- For control patients, admitted within 7 days of the onset of acute neurological symptomatology related to a clinical diagnosis of transient ischaemic attack (TIA) - based on thorough questioning of the patient on admission - and prior to imaging, with an ABCD2≥ 2 score.
- Express consent to participate in the study.
- Member or beneficiary of a social security.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Hopital Fondation Adolphe de Rothschild Coordinator of this site? Confirm its status | Paris | France | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.