NCT04975464Active, not recruiting
BRINK (BRain In Kidney Disease) Memory Study 2.0
BRINK (BRain In Kidney Disease) Memory Study 2.0 (The Natural History of Cognitive Decline in Chronic Kidney Disease: Renal, Vascular and Alzheimer's Disease Contributions)
Source: ClinicalTrials.gov · Last updated 4 Nov 2025
Brief summary (registry, in English)
In this study, the investigators will be looking at results of tests of memory and thinking and daily activities in a group of people without known chronic kidney disease (CKD) , and a group of CKD patients, and follow the participants for up to four more years, including after the participants start dialysis or receive a transplant. The investigators are doing this study to compare how often memory loss, confusion and difficulty with daily activities occur in those without and those with CKD. Additionally, the investigators are doing this study to identify risk factors for memory and thinking problems in CKD patients. The information received through the NDI will be utilized to help track our study population and help provide useful information regarding cause of death of those in our study.
- Status (registry)
- Active, not recruiting
- Study type
- Observational
- Enrollment
- 600 (actual)
- First submitted
- 14 Jul 2021
- Start date
- 15 Nov 2011
- Primary completion date
- May 2026
- Lead sponsor
- Anne Murray
- Diseases
- Chronic kidney disease, Stroke, Alzheimer disease
- NCT number
- NCT04975464
What you commit to
- Study type: Observational
- Participants enrolled: 600
- From 15 Nov 2011 to the primary completion date, May 2026
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Acute psychiatric illness that would impede cognitive testing
Other
- Active chemical dependence
- Legally blind or unable to complete cognitive tests due to visual loss or deafness
Who the study is looking for
- In stages 3b-5 of chronic kidney disease (GFR ≤ 60 ± 5 ml/min/1.73m2) at the first baseline visit in BRINK 1.0.
- Able to complete an approximately 90 minute cognitive and physical testing battery.
- Able to sign the informed consent, or allow a caregiver, relative, surrogate, or witness to sign the informed consent if participant is unable to do so.
- GFR ≥ 60 ± 5 ml/min/1.73m2 at the first baseline visit in BRINK 1.0.
- Able to complete an approximately 90 minute cognitive and physical testing battery.
- Able to sign the informed consent, or allow a caregiver, relative, surrogate, and/or witness to sign the informed consent if participant is unable to do so.
Age in the registry: 50 years to - · Sex: All · Accepts healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Hennepin Healthcare Research Institute Coordinator of this site? Confirm its status | Minneapolis | United States | Unknown status |
| Minneapolis VA Healthcare System Coordinator of this site? Confirm its status | Minneapolis | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.