NCT04977856Completed
Efficacy and Cost-effectiveness of Internet-delivered CBT for Adolescents With Depression
Efficacy and Cost-effectiveness of Internet-delivered Cognitive Behavior Therapy for Adolescents With Mild to Moderate Depression: A Randomized Controlled Trial of Guided and Self-guided ICBT vs. Treatment as Usual
Source: ClinicalTrials.gov · Last updated 1 Jun 2026
Brief summary (registry, in English)
Adolescent depression is a prevalent and impairing condition that can be effectively treated with Cognitive Behavior Therapy (CBT). However, a majority of adolescents do not have access to CBT. Internet-delivered CBT (ICBT) has been suggested as a way to increase availability to effective psychological treatments. Yet, the research on ICBT for adolescents has been lagging behind significantly. The overall aim of this research project is to increase the availability of evidence-based psychological treatments for adolescents with depression by developing and evaluating internet-delivered Cognitive Behavior Therapy (ICBT) for this target group. The main objectives are to establish the efficacy, cost-effectiveness, and long-term effects of the guided and self-guided ICBT for adolescents with mild to moderate depression in a randomized controlled trial (RCT) with three-arms; guided ICBT (with therapist-support) and self-guided ICBT (without therapist-support) vs treatment as usual (TAU).
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 219 (actual)
- First submitted
- 13 Jul 2021
- Start date
- 10 Sept 2021
- Primary completion date
- 14 Oct 2024
- Lead sponsor
- Region Stockholm
- Diseases
- Depression
- NCT number
- NCT04977856
What you commit to
- Study type: Interventional
- Participants enrolled: 219
- From 10 Sept 2021 to the primary completion date, 14 Oct 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previous psychological treatment for MDD (CBT, interpersonal psychotherapy (IPT), or BA) for a minimum of at least 3 sessions within the last 12 months prior to assessment.
Other illness
- The presence of psychiatric problems requiring immediate treatment (e.g., high risk of suicide, psychosis, severe self-injury, bipolar disorder, clinical eating disorder, alcohol/substance abuse),
- Ongoing psychological treatment for any psychiatric disorder.
Other
- Social problems requiring immediate action (e.g., ongoing abuse in the family, high and prolonged absence from school);
- Current use of benzodiazepines.
Who the study is looking for
- 13-17 years of age,
- A diagnosis of mild to moderate MDD based on the DSM-5,
- Willing to be randomized to either of the three treatment arms,
- Basic proficiency in Swedish, both adolescent, and a participating caregiver
- Regular access to a desktop, laptop computer connected to the internet, as well as a mobile phone,
- If using medication with antidepressants, central stimulants, or neuroleptics it has to be unchanged at least 6 weeks prior to inclusion, and
- A minimum of one caregiver that is able to co-participate in the treatment.
Age in the registry: 13 years to 17 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| BUP Internetbehandling, BUP Forsknings- och utvecklingscentrum i Stockholm Coordinator of this site? Confirm its status | Stockholm | Sweden | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.