NCT04982419RecruitingPhase 2/3
Remote Ischemic Preconditioning for Renal and Cardiac Protection in Congestive Heart Failure (RICH) Trial
Source: ClinicalTrials.gov · Last updated 15 Dec 2025
Brief summary (registry, in English)
This is a prospective, double-blind, sham-controlled, multicenter, randomized clinical trial is to study the effects of remote ischemic preconditioning on contrast-associated acute kidney injury, functional capacity, and major adverse kidney events in in patients with congestive heart failure undergoing cardiac catheterization and/or percutaneous coronary intervention.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 2/3
- Study type
- Interventional
- Enrollment
- 240 (estimated)
- First submitted
- 26 Jul 2021
- Start date
- 1 Nov 2021
- Primary completion date
- 31 Mar 2028
- Lead sponsor
- VA Office of Research and Development
- Diseases
- Heart failure, Coronary artery disease
- NCT number
- NCT04982419
What you commit to
- Study type: Interventional · Phase 2/3
- Planned participants: 240
- From 1 Nov 2021 to the primary completion date, 31 Mar 2028
- 3 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Kidney transplant
- Prior exposure to contrast media within 72hrs preceding coronary angiography
Other illness
- Upper limb peripheral arterial disease
- Renal disease requiring dialysis
Other
- Inability to give informed consent
- Unstable BP (SBP \> 200 or \<80 mmHg) at the time of enrolment
- Unavailability of at least one arm for RIPC/Sham-RIPC application
- Pregnancy
- Prisoner
Who the study is looking for
- Age 18 years
- Diagnosis of heart failure with reduced LVEF \<50%
- Pre-procedure intravenous normal saline fluid restriction status
- Society for Cardiovascular Angiography and Interventions (SCAI) AKI risk score (\>1%)
- Referral for coronary angiogram and/or PCI
- Suspected stable coronary artery disease or acute coronary syndrome
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (3)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| VA North Texas Health Care System Dallas VA Medical Center, Dallas, TX Coordinator of this site? Confirm its status | Dallas | United States | Recruiting |
| VA Pittsburgh Healthcare System University Drive Division, Pittsburgh, PA Coordinator of this site? Confirm its status | Pittsburgh | United States | Recruiting |
| Hunter Holmes McGuire VA Medical Center, Richmond, VA Coordinator of this site? Confirm its status | Richmond | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.