NCT04986033Completed
Association Between Vitamin D and Perioperative Hemoglobin Levels in Patients Undergoing Off-pump Coronary Artery Bypass Graft Surgery: Role of Hepcidin
Source: ClinicalTrials.gov · Last updated 2 Oct 2025
Brief summary (registry, in English)
Preoperative anemia is present in more than 50% of patients undergoing cardiac surgery, which is associated with increased risk of transfusion, increased length of stay in the intensive care unit, and increased incidence of renal failure and mortality. To date, clinical research on perioperative anemia has been focused on finding and treating other underlying causes of anemia, lowering the threshold for transfusion, and performing careful transfusion. However, recently, it was known that hepcidin and erythroferrone are related to iron metabolism and absorption, vitamin D has an inverse correlation with the development of anemia, and is related to hepcidin concentration control. Therefore, in this study, the relationship between vitamin D, hepcidin concentration and perioperative hemoglobin level in patients with off-pump coronary artery bypass graft surgery was investigated together.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 135 (actual)
- First submitted
- 21 Jul 2021
- Start date
- 1 Aug 2021
- Primary completion date
- 15 Jul 2024
- Lead sponsor
- Yonsei University
- Diseases
- Coronary artery disease
- NCT number
- NCT04986033
What you commit to
- Study type: Observational
- Participants enrolled: 135
- From 1 Aug 2021 to the primary completion date, 15 Jul 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Cooperative operation with other surgery
Other illness
- Patients who have a end stage renal disease and need a hemodialysis
- Patients who have a some disease(leukemia, myeloma, aplastic anemia, sickle cell anemia, etc) affecting hematopoiesis
Lab values
- Patients with chronic kidney disease (eGFR \< 30)
- Patients with a low hemoglobin (Hb \< 10) before surgery
Other
- Emergency operation
- Minimal invasive coronary artery bypass graft
- Patients who need a mechanical ventricular assist device
- Patients with a liver cirrhosis
- Patients who receive vit. D, iron supplements, erythropoietin within 6 months
- Patients who cannot understand the informed consent (eg. Foreigner, patients with cognitive dysfunction, etc)
- Patients who disagree this study
Who the study is looking for
- 1\. Patients over 20 years of age undergoing off-pump coronary artery bypass graft
Age in the registry: 20 years to - · Sex: All
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Division of Cardiac Anesthesiology, Department of Anesthesiology and Pain Medicine, Cardiovascular Hospital, Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea Coordinator of this site? Confirm its status | Seoul | South Korea | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.