NCT04991519Active, not recruiting
Brain-based Understanding of Individual Language Differences After Stroke
Understanding the Brain Basis of Language and Cognitive Functions Through the Study of Individuals With Brain Injury and Healthy Controls
Source: ClinicalTrials.gov · Last updated 12 Nov 2024
Brief summary (registry, in English)
Strokes often cause a loss of communication ability, referred to as aphasia, as well as cognitive difficulties. Each stroke survivor has a unique pattern of strengths and weaknesses in communication and cognition, and a unique course of recovery. The BUILD study aims to understand the brain basis of these individual differences in stroke outcome. Participants with stroke as well as controls matched in age, educational background, race, and sex are examined using a combination of standardized and in-house tests of language and cognition to provide a detailed profile of strengths and weaknesses. Each participant will have between three and six sessions, including an MRI to measure details of the structure, function, and connections in the brain. The data are analyzed to test how patterns in the stroke lesion explain the patterns of communication and cognitive difficulties, and how patterns in the uninjured parts of the brain explain resilience and recovery from the stroke. Ultimately, we hope that BUILD will guide us toward new targets for brain stimulation treatments or other biologically based treatments that improve language and cognitive abilities after stroke.
- Status (registry)
- Active, not recruiting
- Study type
- Observational
- Enrollment
- 400 (estimated)
- First submitted
- 1 Jul 2021
- Start date
- 1 Nov 2018
- Primary completion date
- 30 Aug 2028
- Lead sponsor
- Georgetown University
- Diseases
- Stroke
- NCT number
- NCT04991519
What you commit to
- Study type: Observational
- Planned participants: 400
- From 1 Nov 2018 to the primary completion date, 30 Aug 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- History of other brain conditions that could impact interpretation of results (such as multiple sclerosis, premorbid dementia)
- Severe psychiatric condition that would interfere with participation in the study
- History of a learning disability that could impact interpretation of results
- Additional Exclusion Criteria for MRIs:
Other
- Pacemaker or magnetic metal in the body that is not MRI compatible
- Pregnancy
- Claustrophobia
Who the study is looking for
- Stroke Survivors:
- Age \>=18
- Stroke in left hemisphere of brain with or without aphasia, or stroke elsewhere causing aphasia
- Learned English at 8 years or younger
- Controls:
- Age \>=18
- No history of brain injury resulting from stroke, trauma, infection (i.e. encephalitis), or tumor
- Learned English at 8 years or younger
Age in the registry: 18 years to - · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Georgetown University Medical Center Coordinator of this site? Confirm its status | Washington D.C. | United States | Unknown status |
Related publications
- Right Hemisphere Functional Connectivity Increases in Proportion to Left Hemisphere Lesion Size, but Not Within the Language Network.Hum Brain Mapp · 2026 · PMID 42698375
This page is information, not medical advice. Discuss any trial with your doctor.