NCT04991961Completed
Effect of Anti-hypertensive Medications on the Diagnostic Accuracy in Primary Aldosteronism
Effect of Anti-hypertensive Medications on the Diagnostic Accuracy in Primary Aldosteronism：a Prospective Study
Source: ClinicalTrials.gov · Last updated 14 Aug 2025
Brief summary (registry, in English)
To evaluate the effect of anti-hypertensive medication on efficiency of primary aldosteronism screening and confirmatory test, and to determine the appropriate diagnostic cutoff value for Chinese hypertension patients during antihypertensive drugs therapy.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 341 (actual)
- First submitted
- 28 Jul 2021
- Start date
- 15 Sept 2020
- Primary completion date
- 31 Oct 2024
- Lead sponsor
- Chongqing Medical University
- Diseases
- High blood pressure
- NCT number
- NCT04991961
What you commit to
- Study type: Observational
- Participants enrolled: 341
- From 15 Sept 2020 to the primary completion date, 31 Oct 2024
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Lab values
- Patients hard to change or stop the medication for accomplish the screening test or diagnosis Unwilling to participate the study and refuse to sign on informed consent Patients who was diagnosed with other secondary hypertension Suspected with PA（rein concretion beyond the limit of normal reference range after stoping or changing the medication） Severe renal insufficiency （eGFR\<30 ml/min/1.73m2）; pregnancy
Who the study is looking for
- Persistent hypertension \>150/100mmHg, including previously diagnosed grade 2 hypertension but well controlled by 1-2 drugs; newly diagnosed hypertension with 3 days blood pressure \> 150 / 100mmHg
- Resistant hypertension(combined with three antihypertensive drugs and one of them is diuretic but blood pressure is still greater than 140 / 90 mmHg ; or need to combined four anti-hypertensive drugs to control the blood pressure under 140 / 90 mmHg)
- Family history of hypertension with early onset (\< 40 years old)
- Family history of hypertension with early onset (\<40 years old) and cerebrovascular accident
- Hypertension with spontaneous or diuretic hypokalemia
- Hypertensive with adrenal incidentaloma
- Hypertensive with OSAS
- First-degree relatives of PA patients and with hypertension Stable antihypertensive medication therapy for more than 2 weeks, medication including：β-blockers, CCB, ACEi, ARB, MRA, and other diuretics.
Age in the registry: 10 years to 90 years · Sex: All · Does not accept healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Qifu Li Coordinator of this site? Confirm its status | Chongqing | China | Unknown status |
| The First Affiliated Hospital of Chongqing Medical University Coordinator of this site? Confirm its status | Chongqing | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.