NCT04994301Completed
Evaluation of Lung T1-MRI in Pediatric Cystic Fibrosis Patients
Lung T1 MRI Assessments of Children With CF Initiating Trikafta Therapy
Source: ClinicalTrials.gov · Last updated 14 Sept 2026
Brief summary (registry, in English)
In this observational study, the investigators evaluate the sensitivity of T1-MRI to identify lung perfusion changes in pediatric patients with CF (age = 6-11) before and after initiating FDA-approved Trikafta therapy. The investigators compare these Lung T1 MRI assessments (% Normal lung perfusion) to currently best-available assessments of lung function in CF patients (i.e., MBW (LCI( and Spirometry (FEV1 % Predicted).
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 48 (actual)
- First submitted
- 29 Jul 2021
- Start date
- 15 Dec 2020
- Primary completion date
- 15 Dec 2023
- Lead sponsor
- University Hospitals Cleveland Medical Center
- Diseases
- Cystic fibrosis
- NCT number
- NCT04994301
What you commit to
- Study type: Observational
- Participants enrolled: 48
- From 15 Dec 2020 to the primary completion date, 15 Dec 2023
- 3 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Subjects with MRI contraindication (e.g., heart pacemaker, heart defibrillator, metal in within the body.
Other
- Subject who cannot hold their breath for up to 15 seconds.
- Subjects who are pregnant.
Who the study is looking for
- Male or female individuals with a diagnosis of cystic fibrosis and have at least one copy of the F508del mutation.
Age in the registry: 5 years to 11 years · Sex: All · Does not accept healthy volunteers
Sites (3)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| CS Mott Children's Hospital Coordinator of this site? Confirm its status | Ann Arbor | United States | Unknown status |
| University Hospitals Cleveland Medical Center* Coordinator of this site? Confirm its status | Cleveland | United States | Unknown status |
| Riley Hospital for Children Coordinator of this site? Confirm its status | Indianapolis | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.