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NCT04998136CompletedPhase 3

Research Study Investigating How Well Semaglutide Works in People From Thailand and South Korea Living With Obesity

Efficacy and Safety of Semaglutide 2.4 mg Once-weekly in Asians With Obesity Diagnosed as BMI ≥ 25 kg/m2 According to Local Guidelines

Source: ClinicalTrials.gov · Last updated 30 Dec 2025

Brief summary (registry, in English)

This study looks at how well semaglutide helps people lose weight. This study will look at the change in the participants' body weight from the start to the end of the study. The study compares the weight loss in people who get semaglutide to the weight loss in people who get placebo. Placebo is a "dummy" medicine that looks like the study medicine, but has no effect on the body. Participants will either get semaglutide or "dummy" medicine - which treatment participants get is decided by chance. Participants will need to take 1 injection once a week. The study medicine is injected with a thin needle in a skin fold in the stomach, thigh or upper arm. Participants will also have talks with study staff about healthy food choices, how to be more physically active and what participants can do to lose weight. The study will last for about a year (50 weeks). Participants will have 10 clinic visits and 8 phone calls. At 6 of the clinic visits participants will have blood samples taken. Participants cannot take part if participants have or have had diabetes. Women cannot take part if pregnant, breast-feeding or plan to get pregnant during the study period.

Status (registry)
Completed
Phase (registry)
Phase 3
Study type
Interventional
Enrollment
150 (actual)
First submitted
4 Aug 2021
Start date
15 Aug 2022
Primary completion date
16 Oct 2023
Lead sponsor
Novo Nordisk A/S
Diseases
Obesity
NCT number
NCT04998136

What you commit to

  • Study type: Interventional · Phase 3
  • Participants enrolled: 150
  • From 15 Aug 2022 to the primary completion date, 16 Oct 2023
  • 16 sites in 2 countries
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • A self-reported change in body weight above 5 kg (11 lbs) within 90 days before screening irrespective of medical records.

Other illness

  • History of type 1 or type 2 diabetes mellitus.

Lab values

  • HbA1c at least 48 mmol/mol (6.5%) as measured by the central laboratory at screening.
  • Renal impairment with estimated Glomerular Filtration Rate (eGFR) below 15 mL/min/1.73 m\^2 at screening.

Other

  • Any participant where a substantial weight loss, in the investigator's opinion, might jeopardise the participant's safety.

Who the study is looking for

  • Age above or equal to 18 years at the time of signing informed consent.
  • BMI at least 25.0 kg/m\^2 at screening.
  • Both parents of Asian descent.
  • History of at least one self-reported unsuccessful dietary effort to lose body weight.

Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (16)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
Konyang University Hospital
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DaejeonSouth KoreaUnknown status
Dongguk University Ilsan Hospital_Gyeonggi-do
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Gyeonggi-doSouth KoreaUnknown status
Hallym University Sacred Heart Hospital
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Gyeonggi-doSouth KoreaUnknown status
Gachon University Gil Hospital
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IncheonSouth KoreaUnknown status
Seoul National University Bundang Hospital
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Seongnam-si, Gyeonggi-doSouth KoreaUnknown status
SMG-SNU Boramae Medical Center
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SeoulSouth KoreaUnknown status
Ajou University Hospital
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SuwonSouth KoreaUnknown status
King Chulalongkorn Memorial Hospital_Endocrinology
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BangkokThailandUnknown status
Ramathibodi Hospital_Nutrition and Biochemical
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BangkokThailandUnknown status
Siriraj Hospital_Bangkok_1
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BangkokThailandUnknown status
King Chulalongkorn Memorial Hospital_Bangkok
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BangkokThailandUnknown status
Obstetrics&Gynecology King Chulalongkorn Memorial Hospital
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BangkokThailandUnknown status
King Chulalongkorn Memorial Hospital_Obstetrics&Gynecology
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BangkokThailandUnknown status
Siriraj Institute of Clinical Research
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BangkokThailandUnknown status
Siriraj Hospital_Dept Cardio
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BangkokThailandUnknown status
Maharaj Nakorn Chiang Mai_Hematology and Oncology
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Chiang MaiThailandUnknown status

This page is information, not medical advice. Discuss any trial with your doctor.