NCT04998136CompletedPhase 3
Research Study Investigating How Well Semaglutide Works in People From Thailand and South Korea Living With Obesity
Efficacy and Safety of Semaglutide 2.4 mg Once-weekly in Asians With Obesity Diagnosed as BMI ≥ 25 kg/m2 According to Local Guidelines
Source: ClinicalTrials.gov · Last updated 30 Dec 2025
Brief summary (registry, in English)
This study looks at how well semaglutide helps people lose weight. This study will look at the change in the participants' body weight from the start to the end of the study. The study compares the weight loss in people who get semaglutide to the weight loss in people who get placebo. Placebo is a "dummy" medicine that looks like the study medicine, but has no effect on the body. Participants will either get semaglutide or "dummy" medicine - which treatment participants get is decided by chance. Participants will need to take 1 injection once a week. The study medicine is injected with a thin needle in a skin fold in the stomach, thigh or upper arm. Participants will also have talks with study staff about healthy food choices, how to be more physically active and what participants can do to lose weight. The study will last for about a year (50 weeks). Participants will have 10 clinic visits and 8 phone calls. At 6 of the clinic visits participants will have blood samples taken. Participants cannot take part if participants have or have had diabetes. Women cannot take part if pregnant, breast-feeding or plan to get pregnant during the study period.
- Status (registry)
- Completed
- Phase (registry)
- Phase 3
- Study type
- Interventional
- Enrollment
- 150 (actual)
- First submitted
- 4 Aug 2021
- Start date
- 15 Aug 2022
- Primary completion date
- 16 Oct 2023
- Lead sponsor
- Novo Nordisk A/S
- Diseases
- Obesity
- NCT number
- NCT04998136
What you commit to
- Study type: Interventional · Phase 3
- Participants enrolled: 150
- From 15 Aug 2022 to the primary completion date, 16 Oct 2023
- 16 sites in 2 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- A self-reported change in body weight above 5 kg (11 lbs) within 90 days before screening irrespective of medical records.
Other illness
- History of type 1 or type 2 diabetes mellitus.
Lab values
- HbA1c at least 48 mmol/mol (6.5%) as measured by the central laboratory at screening.
- Renal impairment with estimated Glomerular Filtration Rate (eGFR) below 15 mL/min/1.73 m\^2 at screening.
Other
- Any participant where a substantial weight loss, in the investigator's opinion, might jeopardise the participant's safety.
Who the study is looking for
- Age above or equal to 18 years at the time of signing informed consent.
- BMI at least 25.0 kg/m\^2 at screening.
- Both parents of Asian descent.
- History of at least one self-reported unsuccessful dietary effort to lose body weight.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (16)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Konyang University Hospital Coordinator of this site? Confirm its status | Daejeon | South Korea | Unknown status |
| Dongguk University Ilsan Hospital_Gyeonggi-do Coordinator of this site? Confirm its status | Gyeonggi-do | South Korea | Unknown status |
| Hallym University Sacred Heart Hospital Coordinator of this site? Confirm its status | Gyeonggi-do | South Korea | Unknown status |
| Gachon University Gil Hospital Coordinator of this site? Confirm its status | Incheon | South Korea | Unknown status |
| Seoul National University Bundang Hospital Coordinator of this site? Confirm its status | Seongnam-si, Gyeonggi-do | South Korea | Unknown status |
| SMG-SNU Boramae Medical Center Coordinator of this site? Confirm its status | Seoul | South Korea | Unknown status |
| Ajou University Hospital Coordinator of this site? Confirm its status | Suwon | South Korea | Unknown status |
| King Chulalongkorn Memorial Hospital_Endocrinology Coordinator of this site? Confirm its status | Bangkok | Thailand | Unknown status |
| Ramathibodi Hospital_Nutrition and Biochemical Coordinator of this site? Confirm its status | Bangkok | Thailand | Unknown status |
| Siriraj Hospital_Bangkok_1 Coordinator of this site? Confirm its status | Bangkok | Thailand | Unknown status |
| King Chulalongkorn Memorial Hospital_Bangkok Coordinator of this site? Confirm its status | Bangkok | Thailand | Unknown status |
| Obstetrics&Gynecology King Chulalongkorn Memorial Hospital Coordinator of this site? Confirm its status | Bangkok | Thailand | Unknown status |
| King Chulalongkorn Memorial Hospital_Obstetrics&Gynecology Coordinator of this site? Confirm its status | Bangkok | Thailand | Unknown status |
| Siriraj Institute of Clinical Research Coordinator of this site? Confirm its status | Bangkok | Thailand | Unknown status |
| Siriraj Hospital_Dept Cardio Coordinator of this site? Confirm its status | Bangkok | Thailand | Unknown status |
| Maharaj Nakorn Chiang Mai_Hematology and Oncology Coordinator of this site? Confirm its status | Chiang Mai | Thailand | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.