NCT05002621Completed
Changes in Gene Transcription and Immunophenotypes Following Mepolizumab Treatment for Asthma
Exploratory Investigation of Changes in Gene Transcription and Immunophenotypes Following Mepolizumab Treatment for Asthma
Source: ClinicalTrials.gov · Last updated 18 Mar 2026
Brief summary (registry, in English)
The purpose of this study is to identify differentially expressed gene transcripts after initiation of mepolizumab in individuals with severe eosinophilic asthma (SEA).
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 20 (actual)
- First submitted
- 9 Aug 2021
- Start date
- 16 Feb 2021
- Primary completion date
- 13 Feb 2023
- Lead sponsor
- Mayo Clinic
- Diseases
- Asthma
- NCT number
- NCT05002621
What you commit to
- Study type: Observational
- Participants enrolled: 20
- From 16 Feb 2021 to the primary completion date, 13 Feb 2023
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study design.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Currently using or have used within 3 months of the initial baseline visit any biologic or immunomodulatory therapy with the exception of #3.
- Currently using or any prior use of rituximab.
- History of upper/lower respiratory tract infection or asthma exacerbation within the previous four weeks of the first baseline visit.
Other illness
- Any prior history of malignancy, autoimmune disease, or immune deficiency.
Age
- Age \< 18 years old.
Other
- Pregnancy.
- Any other significant medical issue as determined by the principal investigator.
Who the study is looking for
- Age ≥ 18 years old.
- Diagnosis of SEA by a health care provider
- History of an absolute eosinophil count ≥ 300/mm\^3
- Prescription for mepolizumab provided during course of routine clinical care but mepolizumab not yet started
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Mayo Clinic in Rochester Coordinator of this site? Confirm its status | Rochester | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.