NCT05007353Completed
The SINgapore GERiatric Intervention Study to Reduce Cognitive Decline and Physical Frailty (SINGER) Study
The SINgapore GERiatric Intervention Study to Reduce Cognitive Decline and Physical Frailty (SINGER) Study, Biomarker and Health Service Research Analyses
Source: ClinicalTrials.gov · Last updated 10 Aug 2026
Brief summary (registry, in English)
A study in Finland found that a multidomain intervention of physical activity, nutritional guidance, cognitive training, social activities and management of vascular risk factors slowed cognitive decline in healthy older adults at increased risk of cognitive decline. A 6-month pilot study was initiated in Singapore, which demonstrated the cultural feasibility and practicality of the FINGER interventions and a set of locally adapted interventions in an Asian population. The SINGER study is a 2-year randomized controlled trial that aims to test the efficacy and safety of these lifestyle changes, including diet and cardiovascular risk factor management, cognitive and physical exercises, in delaying cognitive decline in older adults at risk of dementia.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 1212 (actual)
- First submitted
- 28 Jul 2021
- Start date
- Aug 2021
- Primary completion date
- Dec 2025
- Lead sponsor
- National University of Singapore
- Diseases
- Alzheimer disease
- NCT number
- NCT05007353
What you commit to
- Study type: Interventional
- Participants enrolled: 1212
- From Aug 2021 to the primary completion date, Dec 2025
- 3 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- malignant diseases
- dementia
- symptomatic cardiovascular disease
- other conditions inhibiting from safe engagement in the prescribed intervention and other conditions preventing cooperation, as judged by the study physician
Other
- major depression
- revascularisation within 1 year
- severe loss of vision, hearing or communicative ability
Who the study is looking for
- Age 60-80 years
- Able to understand English/Chinese
- Risk of dementia: Cardiovascular Risk Factors, Aging, and Incidence of Dementia (CAIDE) dementia risk score ≥6 indicating the presence of modifiable risk factors Modifiable lifestyle factors (fulfilling at least one of the following LIBRA index for diet, cognitive activity, physical activity)
- Cognitive performance at the mean level or slightly lower than expected for age (MoCA ≥18, ≤27)
- No plans to travel outside of Singapore for an extended period of time over the course of the study
- Free of physical disabilities that preclude participation in the study
- Willing to complete all study-related activities for 24 months
- Willing to be randomized to either lifestyle intervention group
Age in the registry: 60 years to 80 years · Sex: All · Accepts healthy volunteers
Sites (3)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| National Neuroscience Institute @ Tan Tock Seng Campus (NNI @ TTSH campus) Coordinator of this site? Confirm its status | Singapore | Singapore | Unknown status |
| National University Hospital Coordinator of this site? Confirm its status | Singapore | Singapore | Unknown status |
| National University of Singapore, Yong Loo Lin School of Medicine Coordinator of this site? Confirm its status | Singapore | Singapore | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.