NCT05008198Active, not recruiting
Assessing an EEG Biomarker of Response to TMS for Major Depression
Assessing an Electroencephalography (EEG) Biomarker of Response to Transcranial Magnetic Stimulation for Major Depression
Source: ClinicalTrials.gov · Last updated 22 Oct 2025
Brief summary (registry, in English)
Veterans with treatment resistant depression (TRD) have the opportunity to receive transcranial magnetic stimulation (TMS) treatment via the VA's National TMS Clinical Pilot Program. While some see improvement with their depression, others do not. Therefore, it may be beneficial to be able to predict with biomarkers what participants may see improvement with their treatment. Electroencephalography (EEG) is a means to identify such biomarkers. Four hundred Veterans with TRD will be enrolled in this trial to determine whether neuroimaging biomarkers of repetitive transcranial magnetic stimulation (TMS) can be prospectively replicated in a large ecologically valid sample. Participants will have a total of EEG scans at baseline, every 5th treatment session, and at the end of treatment for a total of 7 EEG scans.
- Status (registry)
- Active, not recruiting
- Study type
- Observational
- Enrollment
- 266 (actual)
- First submitted
- 30 Jul 2021
- Start date
- 19 Aug 2021
- Primary completion date
- 30 Sept 2025
- Lead sponsor
- VA Office of Research and Development
- Diseases
- Depression
- NCT number
- NCT05008198
What you commit to
- Study type: Observational
- Participants enrolled: 266
- From 19 Aug 2021 to the primary completion date, 30 Sept 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- History of seizure disorder
- Known structural or neurologic abnormalities present or close to the treatment site that would increase risk of seizure
- History of brain surgery
- History of recent traumatic brain injury (within 6 months) or any history of moderate to severe traumatic brain injury
- Clinical evidence of severe or uncontrolled alcohol or substance use disorders within three months
Other
- Active withdrawal from alcohol or other substances of abuse
- Implanted metal device in the head that would increase the risk of TMS
- Metal in the head that would increase the risk of TMS
- Current psychosis
Who the study is looking for
- Veterans participating in the VA TMS Pilot Program age 18 years or older
- Able to provide written informed consent to participate in the EEG portion of this study and to allow linking such data to data collected as part of the TMS Pilot Program
- Diagnosis of MDD based on DSM-5 criteria and be currently depressed despite prior treatment with at least one adequate antidepressant treatment
- Receiving stable doses of psychiatric medications (no dose changes for \>4 weeks prior to study entry), in stable psychotherapy, or receiving no psychiatric medications and/or psychotherapy
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| White River Junction VA Medical Center, White River Junction, VT Coordinator of this site? Confirm its status | White River Junction | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.