NCT05012813Completed
Humidified Forest Oils for Immune System Recovery in Stage I-III Breast or Prostate Cancer
Feasibility of Substitution of Volatile Organic Compound Humidification to Simulate the Forest Experience Effects on Immune System Recovery
Source: ClinicalTrials.gov · Last updated 9 Mar 2026
Brief summary (registry, in English)
This clinical trial studies the feasibility of simulating forest therapy using humidified wood or fragrant oils, in improving immune cells, like natural killer cells, number and activity, and their downstream proteins, perforin and granulysin in patients with stage I-III breast or prostate cancer who completed chemo- and/or radiation therapy. The knowledge gained from this study may help cancer patients who have compromised immune systems and who also cannot participate in outdoor activities like exercise or forest walks.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 28 (actual)
- First submitted
- 6 Aug 2021
- Start date
- 19 Jul 2022
- Primary completion date
- 28 Feb 2025
- Lead sponsor
- OHSU Knight Cancer Institute
- Diseases
- Prostate cancer
- NCT number
- NCT05012813
What you commit to
- Study type: Interventional
- Participants enrolled: 28
- From 19 Jul 2022 to the primary completion date, 28 Feb 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Febrile illness/infection within previous two weeks. Rationale, immune biomarkers will reflect previous febrile illness
- Prior autoimmune disease, are on immune-modulating therapies (endocrine therapy allowed). Rationale, because of their poor prognosis rather than being in early stages of cancer
Other illness
- If they have a known allergy to citrus peel or pine forests. Rationale: forest oils may cause contact dermatitis and coughing
- First diagnosis of breast or prostate cancer is longer than 12 months ago. Rationale, NK cell number recovery may be complete by this time after first treatment
- Had surgery or invasive procedure in the past two months. Rationale, because of their poor prognosis rather than being in early stages of cancer
Other
- If they have asthma. Rationale: forest oils may be a possible trigger for asthma
- If they are unable to detect common odors from commercial fragrances. Rationale, forest oils are humidified as an aroma to be inhaled in the simulate the forest greenspace immersion (SFIT)
- Current tobacco or tobacco use within 1 hour of start of SFIT. Rationale: forest oils may cause contact dermatitis and coughing
- Inability to complete study requisites
Who the study is looking for
- Age \>= 18 years. Both men and women and members of all races and ethnic groups will be included
- Participants must have histologically or cytologically confirmed breast cancer or prostate cancer (hormone therapy excepted) who are in stage I-V with or without evidence of metastasis using the Cancer Therapy Evaluation Program (CTEP) Simplified Disease Classification
- Participants must be within 12 months of their first diagnosis of breast or prostate cancer
- Criteria for solid tumors: Participants must have measurable disease, per doctor of medicine (MD) and data in medical record
- Participants must have no history of autoimmune disease
- Ability to understand and the willingness to sign a written informed consent document
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| OHSU Knight Cancer Institute Coordinator of this site? Confirm its status | Portland | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.