NCT05014802Recruiting
Baseline Atrial Fibrosis Predicts Risk for Post-operative Atrial Fibrillation in Patients Undergoing Cardiac Surgery
Baseline Atrial Fibrosis Predicts Risk for Post-operative Atrial Fibrillation in Patients Undergoing Cardiac Surgery: A Pilot Study for SAPPORO-AF
Source: ClinicalTrials.gov · Last updated 15 Jun 2026
Brief summary (registry, in English)
The study aims to evaluate and compare the incidence of atrial arrhythmias (including Post-Operative Atrial Fibrillation (POAF), atrial flutter, and atrial tachycardia) stratified by baseline Utah fibrosis stages and overall fibrosis (%) of the left atrial wall area. The investigators hypothesize that patients with a higher baseline Utah fibrosis staging will experience a higher incidence of POAF. The study also aims to evaluate and compare the in-hospital mortality, length-of-stay (LOS), complication rates (strokes, pneumonia, respiratory failure etc.) of the different Utah fibrosis stage cohorts. Perform cost analysis and compare between patients with POAF and patients without POAF. The investigators hypothesize that patients experiencing POAF will have a higher mortality rate, longer LOS, greater complications, and therefore, additional hospital costs.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 50 (estimated)
- First submitted
- 13 Aug 2021
- Start date
- Nov 2021
- Primary completion date
- Dec 2026
- Lead sponsor
- Tulane University
- Diseases
- Atrial fibrillation
- NCT number
- NCT05014802
What you commit to
- Study type: Observational
- Planned participants: 50
- From Nov 2021 to the primary completion date, Dec 2026
- 3 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patients who have previously undergone extracorporeal membrane oxygenation (ECMO)
- Patients with any health related Late Gadolinium Enhancement (LGE)-MRI contraindications (including previous allergic reaction to gadolinium, pacemakers, defibrillators, other devices/implants contraindicated for MRI)
Other illness
- Patients with a history of atrial arrhythmia (atrial fibrillation, atrial flutter, atrial tachycardia)
- Patients with a history of cardiac or open chest surgery
- Patients with a history of catheter ablation
- Patients who have undergone or will undergo heart transplantation
- Patients with cognitive impairment preventing them from giving informed consent will be excluded from the study
Lab values
- Acute or chronic severe renal disease with a low glomerular filtration rate (GFR), \<30 mL per minute per 1.73 m2 will be excluded from the trial. (A creatinine measurement should be available within the last 6 months. If not, a creatinine blood test will be drawn to assess for renal function before the MRI acquisition).
Age
- Patients under the age of 40
Other
- Patients with left ventricular assist device (LVAD) or scheduled to have LVAD implanted
- Patients weighing \> 300 lbs. (MRI image quality decreases due to increased body mass index)
- Patients currently pregnant or breastfeeding, or plan to become pregnant during the study period
- Patients who cannot read, speak, and/or understand English
Who the study is looking for
- Male or female patients age 40 years of age or older
- Patients with no history of atrial arrhythmia (atrial fibrillation, atrial flutter, atrial tachycardia) scheduled to undergo cardiac surgery (These surgeries include but are not limited to coronary artery bypass graft (CABG), valvular repair/reconstruction, aneurysm repair, and insertion of pacemaker).
Age in the registry: 40 years to 120 years · Sex: All · Does not accept healthy volunteers
Sites (3)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Lakeview Hospital Coordinator of this site? Confirm its status | Covington | United States | Recruiting |
| East Jefferson General Hospital Coordinator of this site? Confirm its status | New Orleans | United States | Recruiting |
| Washington University (Barnes-Jewish Hospital) Coordinator of this site? Confirm its status | St Louis | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.