NCT05015660Recruiting
Conduction System Pacing With Left Bundle Branch Pacing as Compared to Standard Right Ventricular Pacing
LEFT Bundle Pacing vs Standard Right Ventricular Pacing for Heart Failure
Source: ClinicalTrials.gov · Last updated 11 Mar 2026
Brief summary (registry, in English)
High burden right ventricular (RV) pacing has been shown to increase cardiovascular mortality, incidence of heart failure (HF), worsen left ventricular (LV) function and accelerate the development of atrial fibrillation (AF). High percentage ventricular pacing and wider paced QRS in the setting of normal baseline LV ejection fractions have consistently been shown to be independent risk factors for pacing-induced cardiomyopathy. Left bundle branch pacing (LBBP) has emerged as a potential alternative pacing mechanism that may avoid LV dyssynchrony and pacing-induced LV dysfunction by mimicking native electrical conduction.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 1300 (estimated)
- First submitted
- 10 Aug 2021
- Start date
- 1 Sept 2022
- Primary completion date
- 1 Dec 2026
- Lead sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
- Diseases
- Heart failure
- NCT number
- NCT05015660
What you commit to
- Study type: Interventional
- Planned participants: 1300
- From 1 Sept 2022 to the primary completion date, 1 Dec 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Any prior attempt at implantation of an ICD, CRT, HBP, or LBBP
Age
- Other serious medical condition with life expectancy of \<2 years
Other
- Indication for an implantable cardioverter defibrillator
- Presence of a mechanical tricuspid valve
- Lack of capacity to consent
- Pregnancy
- Patients in whom the conduction system abnormality is expected to be transient or recover over time
- Patients with permanent atrial fibrillation
Who the study is looking for
- Age ≥ 18 years
- Patients with an ejection fraction of \>35%
- Patients with an indication for ventricular pacing and high-degree atrioventricular block where the degree of anticipated RV pacing is \>90% including:
- Third degree AV block
- Symptomatic or asymptomatic second-degree AV block
- First degree AV block ≥ 280ms with a narrow QRS, or ≥ 240ms with an intraventricular delay (QRS duration ≥120ms)
- Echocardiogram within the last 3 months, with ability to have DICOM images
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| McGill University Health Centre Research Institute Coordinator of this site? Confirm its status | Montreal | Canada | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.