NCT05017779Completed
A Hybrid Effectiveness-implementation Trial of a High School-based Executive Function Treatment for Autistic Youth
A Hybrid Effectiveness-implementation Trial of a School Based Executive Function Treatment for Transition Age Autistic Youth
Source: ClinicalTrials.gov · Last updated 10 Feb 2026
Brief summary (registry, in English)
This study will test the effectiveness of a school-based cognitive behavioral executive function (EF) intervention, Unstuck \& On Target High School (UOT:HS), for transition-age youth with autism spectrum disorder (ASD). UOT:HS was designed to be embedded in high schools and delivered by school staff to improve generalization of skills, increase access to mental health care, and fill a gap in evidence-based approaches to support postsecondary transition. UOT:HS targets flexibility and planning skills and focuses on key functions needed for adult success across 25, 1-hour lessons. School staff will be trained to deliver UOT:HS, study staff will provide ongoing check-ins, and parents will be offered home extensions for each lesson and two trainings to generalize skills to the home environment. Behavioral and parent-report data will be collected prior to intervention, post-intervention, and at 4-to-6-month follow-up.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 178 (actual)
- First submitted
- 27 Jul 2021
- Start date
- 7 Sept 2021
- Primary completion date
- 15 Dec 2025
- Lead sponsor
- Children's National Research Institute
- Diseases
- Autism
- NCT number
- NCT05017779
What you commit to
- Study type: Interventional
- Participants enrolled: 178
- From 7 Sept 2021 to the primary completion date, 15 Dec 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other
- Students must have a level of proficiency in English to complete questionnaires and study procedures in English. Parents must have a level of proficiency in English or Spanish to complete questionnaires and study procedures in English or Spanish.
- Student is not able to participate in UOT:HS due to their schedule or ability to benefit from curriculum material as determined by teacher.
Who the study is looking for
- Cognitive/Behavioral capacity to benefit and understand Unstuck material as determined by teacher guided by probes related to pragmatic language that align with verbal demands of the curriculum.
- Evidence of autism supported by at least one of the following:
- Eligible and/or receiving school-based services or supports for autism
- Prior clinical diagnosis of autism from a qualified health professional (as indicated by parent report)
- Demonstrates characteristics of autism consistent with DSM-5, as judged by a clinical autism expert, based on all available information gathered through the screening, consenting, and testing process (including information gathered through the Social Communication Questionnaire via parent/teacher report, and SRS-2,)
- Capacity to benefit and understand unstuck material as determined by teacher
Age in the registry: 14 years to 22 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Center for Autism Spectrum Disorders, Children's National Hospital Coordinator of this site? Confirm its status | Rockville | United States | Unknown status |
Related publications
- Self- and parent-reported executive function and self-determination in autistic teens: domain-specific relationships and cross-rater considerations.J Neurodev Disord · 2026 · PMID 42958037
This page is information, not medical advice. Discuss any trial with your doctor.