NCT05022147Active, not recruitingPhase 1
Enhancing Gait Using Alternating-Frequency DBS in Parkinson Disease
ENGAGE-PD: Enhancing Gait Using Alternating-Frequency DBS in Parkinson Disease
Source: ClinicalTrials.gov · Last updated 1 Jul 2026
Brief summary (registry, in English)
The purpose of this study is to assess how alternating-frequency Deep Brain Stimulation (DBS) works to improve postural instability and gait, while also treating other motor symptoms of Parkinson Disease (PD).
- Status (registry)
- Active, not recruiting
- Phase (registry)
- Phase 1
- Study type
- Interventional
- Enrollment
- 12 (estimated)
- First submitted
- 9 Aug 2021
- Start date
- 4 Oct 2021
- Primary completion date
- 15 Nov 2024
- Lead sponsor
- James Liao
- Diseases
- Parkinson disease
- NCT number
- NCT05022147
What you commit to
- Study type: Interventional · Phase 1
- Planned participants: 12
- From 4 Oct 2021 to the primary completion date, 15 Nov 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Concomitant conditions that may affect significantly the evaluation of balance or gait, including orthopedic, rheumatologic or other neurological diseases
- Contraindication to physical therapy
Other illness
- Severity of gait impairment should not require dependency to walker or cane
- Diagnosis of dementia
Age
- Age \< 21
Other
- Cannot tolerate monopolar stimulation at either of the two middle electrode contacts (prerequisite for the recording mode of the DBS) at high frequency (130 Hz) or low frequency (60 Hz).
- Not agreeable to having video taken of entire research visit
Who the study is looking for
- Bilateral STN DBS for PD
- Medtronic Percept PC implanted DBS battery/pulse generator/recording system
- Presence of balance and/or walking impairment and/or freezing of gait
- Can walk without assistance, OFF meds, based on yes/no verbal response
Age in the registry: 21 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Cleveland Clinic Foundation Coordinator of this site? Confirm its status | Cleveland | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.