NGS-based Thyroscan Genomic Classifier in the Diagnosis of Thyroid Nodules

Prior treatment

• Subjects who intend to receive the radiofrequency ablation therapy.

Other illness

• The subject has a history of thyroid tumor.
• The subject is not suitable for fine-needle aspiration biopsy and surgical treatment due to other conditions such as comorbid diseases.
• Other conditions determined by the researcher that do not meet the criteria of enrollment.

• Patients sign the informed consent form for participating in the reasearch study.
• Patient's age is 18 years or older.
• Ultrasound showed at least one thyroid nodule, and it was classified as C-TIRADS Category 3/4.
• The surgeon has confirmed surgical indication and the subject is willing to undergo the planned surgical intervention at the participating medical institution; or cytology results are benign, and the nodule(s) have remained clinically stable-defined as absence of new high-risk ultrasound features and no significant change in size on serial imaging.
• Surgical indications include but are not limited to one of the following conditions: 1) Thyroid nodules are compressed or affect aesthetics; 2) The patient's subjective wishes require surgical removal of the nodules; 3) FNA samples with indeterminate cytology are classified as Bethesda III and IV, requiring diagnostic surgery; 4) After the investigator's assessment, there are other surgical indications.
• Preoperative FNAB to obtain sufficient cells.