NCT05027789Active, not recruiting
Brain Boosters 2 in Persons at Risk for Alzheimer's Disease: a Digital Application Supported Intervention
Compensation Training and Lifestyle Modifications to Promote Healthy Aging in Persons at Risk for Alzheimer's Disease: a Digital Application Supported Intervention (Brain Boosters 2)
Source: ClinicalTrials.gov · Last updated 13 Oct 2026
Brief summary (registry, in English)
The purpose of this research is to determine if training in memory support aids and healthy lifestyle activities (physical exercise, mentally stimulating activities and stress management) can have a positive effect on memory, thinking, and activities that people do every day. Participation in this study will involve being placed into one of two groups: a Self-Guided Intervention Group or a Structured Intervention Group. Both groups will be asked to attend group sessions in which they will be provided education on memory support strategies and lifestyle changes. The Structured Intervention Group will also be provided with an iPad and a digital application (called EMMA) to track their activity. Study participation involves a 6-month intervention and completing outcome measures at 4 different time points for up to a year.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 263 (estimated)
- First submitted
- 5 Aug 2021
- Start date
- 13 Aug 2021
- Primary completion date
- 31 Dec 2026
- Lead sponsor
- University of California, Davis
- Diseases
- Alzheimer disease
- NCT number
- NCT05027789
What you commit to
- Study type: Interventional
- Planned participants: 263
- From 13 Aug 2021 to the primary completion date, 31 Dec 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Has previously participated in a previous version of Brain Boosters, or another study utilizing the Digital Memory Notebook (DMN) application or EMMA.
Other illness
- Known diagnosis of dementia or cognitive impairment;
- Other known neurological condition with potential to affect cognition (e.g., Parkinson's disease)
- Reported history of severe psychiatric disorder (e.g., self-reported history of bipolar disorder or schizophrenia or other psychotic disorder)
Other
- Inability to complete the study protocols due to severe vision or hearing difficulties.
Who the study is looking for
- The target population is cognitively normal older adults with Subjective Cognitive Concerns (SCC). SCC will be operationalized as
- a positive complaint in response to the question: 'Have you experienced a decline in your memory or other aspect of thinking in the last 1-3 years that seems worse than others of your age'
- normal cognition on the modified Telephone Interview of Cognitive Status (mTICS)
- independent function in daily life.
- Age 65 or older
- English speaking
- Lower level of engagement in healthy lifestyle behaviors and compensation use at study baseline (i.e., broadly defined as not a regular exerciser)
- Approval from primary care (due to physical exercise component of the intervention)
- Open to utilizing digital tools such as a digital calendar in daily life
Age in the registry: 65 years to 90 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of California, Davis Alzheimer's Disease Center Coordinator of this site? Confirm its status | Sacramento | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.