NCT05039697Completed
Normobaric Hyperoxia Combined With Endovascular Therapy in Patients With Stroke Within 6 Hours of Onset：Longterm Outcome
Normobaric Hyperoxia Combined With Endovascular Therapy in Patients With Stroke Within 6 Hours of Onset：Longterm Outcome Analysis
Source: ClinicalTrials.gov · Last updated 19 Feb 2025
Brief summary (registry, in English)
The overall incidence of good outcome for AIS following endovascular treatment is only proximately 50%. Whether NBO was safe and effective to improve acute ischemic stroke prognosis is still unclear. The investigators' hypothesis is thatNBO is a safe and effective strategy to improve longterm outcome in AIS patients undergoing endovascular treatment.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 282 (actual)
- First submitted
- 6 Apr 2021
- Start date
- 22 Apr 2021
- Primary completion date
- 4 Feb 2024
- Lead sponsor
- Capital Medical University
- Diseases
- Stroke
- NCT number
- NCT05039697
What you commit to
- Study type: Interventional
- Participants enrolled: 282
- From 22 Apr 2021 to the primary completion date, 4 Feb 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Rapid neurological function improvement, NIHSS score less than 10 points, or evidence of vessel recanalization prior to randomization;
Other illness
- Seizures at stroke onset;
- Intracranial hemorrhage;
- Symptoms suggestive of subarachnoid hemorrhage, even if CT scan was normal;
- Active and chronic obstructive pulmonary disease or acute respiratory distress syndrome;
- \>3 L/min oxygen required to maintain peripheral arterial oxygen saturation (SaO2) 95% as per current stroke management guidelines;
Lab values
- Platelet count of less than 100,000 per cubic millimeter;
Other
- Severe hepatic or renal dysfunction;
- Medically unstable;
- Life expectancy\<90 days;
- Evidence of intracranial tumor;
Who the study is looking for
- Age ≥ 18 years old.
- The clinical symptoms and signs are consistent with acute anterior circulation large vessel occlusion;
- NIHSS score ≥ 10 points;
- (Level of consciousness) NIHSS score 0 or 1;
- The time from onset to randomization is within 6 hours of onset;
- The mRS score before stroke is 0-1;
- The patient has good compliance and can complete the operation with local anesthesia;
- The patient can cooperate with this study and follow-up in the future
- Patient and family members sign informed consent。-
Age in the registry: 18 years to 80 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Baojun Hou Coordinator of this site? Confirm its status | Beijing | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.