NCT05040087Active, not recruiting
Changing the Natural History of Type 2 Diabetes ("CHANGE" Study)
Source: ClinicalTrials.gov · Last updated 12 Aug 2026
Brief summary (registry, in English)
Diabetes is a disorder of high blood glucose, that tends to get worse; over time, patients need more and more drugs. This pattern is caused by overwork of the body's insulin-producing β-cells, because patients' glucose levels are typically above normal; if the investigators kept glucose levels normal - reducing β-cell work - the investigators might be able to keep the disease from getting worse. This trial is aimed to show that adjusting the drugs to keep glucose levels normal, can help to preserve β-cell function compared to usual diabetes care, possibly reduce the tendency to develop the eye and kidney complications of diabetes, and might also be more cost-effective than usual care.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 127 (actual)
- First submitted
- 27 Aug 2021
- Start date
- 1 Sept 2021
- Primary completion date
- 31 Dec 2026
- Lead sponsor
- Foundation for Atlanta Veterans Education and Research, Inc.
- Diseases
- Type 2 diabetes
- NCT number
- NCT05040087
What you commit to
- Study type: Interventional
- Participants enrolled: 127
- From 1 Sept 2021 to the primary completion date, 31 Dec 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- CVD event during the previous year
- bariatric surgery
Other illness
- stage III-IV congestive heart failure
- severe angina
- family or personal history of multiple endocrine neoplasia 2a
- dementia
Lab values
- an estimated glomerular filtration rate \[eGFR\] of ≤50 ml/min
- an alanine aminotransferase (ALT) level \>3x the upper limit of the normal range
Age
- life expectancy \<5 years
Other
- systemic glucocorticoids
- BMI \>40 kg/m2
- pregnancy
- pancreatitis
Who the study is looking for
- diagnosis of diabetes by OGTT
- age 40-75 years
- HbA1c 6.0-7.4%
- 1 hr OGTT glucose \>155 mg/dl in each group
Age in the registry: 40 years to 75 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Atlanta VA Medical Center Coordinator of this site? Confirm its status | Decatur | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.