NCT05043454Completed
Improving Age-Related Cognitive Decline With Exercise in Hypertensive Older Adults
Improving Age-Related Cognitive Decline With Exercise in Hypertensive Older Adults: A Pilot Study to Investigate A Retinal Microvascular Biomarker and the Role of IGF
Source: ClinicalTrials.gov · Last updated 27 Feb 2026
Brief summary (registry, in English)
The investigator aims to assess the extent to which a brief exercise intervention improves systemic growth factor concentrations, reverses loss of systemic vascular networks and hypertension, and by extension, improves neurocognition. To test the investigator's hypothesis that increased cardiovascular fitness will correlate with improved vascular density, the investigator proposes the innovative use of retinal density scans.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 11 (actual)
- First submitted
- 25 Aug 2021
- Start date
- 1 Oct 2021
- Primary completion date
- 9 Jul 2025
- Lead sponsor
- University of Alabama at Birmingham
- Diseases
- High blood pressure
- NCT number
- NCT05043454
What you commit to
- Study type: Interventional
- Participants enrolled: 11
- From 1 Oct 2021 to the primary completion date, 9 Jul 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- diagnosis of dementia
- disease or condition that would preclude exercise
- untreated depression or anxiety disorders
- severe respiratory disease
- disease of the eye
Other
- resting systolic blood pressure \<120, or \>180 mm Hg
- refractive error \> 6 diopters or +6 diopters (as assessed by 1st retinal scan).
Who the study is looking for
- adults between 55-75 years of age
- essential hypertension (as determined by referring physicians)
- engages in less than 150 minutes of moderate intensity exercise/week (as determined by CHAMPS Questionnaire)
- physically able to exercise
- access to an upright cycle ergometer at home or via gym access
- access to smart device (iOS or Android phone or tablet with ability to install and use Polar Beat and Polar FlowTM applications).
Age in the registry: 55 years to 75 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Alabama at Birmingham Coordinator of this site? Confirm its status | Birmingham | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.