NCT05057507Completed
Realistic Computational Electrophysiology Simulations for the Targetted Treatment of Atrial Fibrillation
Source: ClinicalTrials.gov · Last updated 5 Jun 2026
Brief summary (registry, in English)
The aim of this research is to classify patients by the dominant mechanism of continuous atrial electrical activation during atrial fibrillation. This approach seeks to improve on existing classifications which are based solely on the duration of the arrhythmia (\<7 days, \>7 days and \>1 year). This is a cohort study. Patients undergoing clinically indicated electrophysiology study or AF ablation will have invasive assessment of cardiac electrophysiological profile at the time of their planned procedure, undergo 2-week ambulatory monitoring before and after the procedure, complete symptom questionnaires before and after their procedure and undergo atrial cardiac magnetic resonance imaging before their procedure.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 91 (actual)
- First submitted
- 16 Sept 2021
- Start date
- 7 Jan 2022
- Primary completion date
- 7 Jan 2024
- Lead sponsor
- University of Edinburgh
- Diseases
- Atrial fibrillation
- NCT number
- NCT05057507
What you commit to
- Study type: Observational
- Participants enrolled: 91
- From 7 Jan 2022 to the primary completion date, 7 Jan 2024
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Prior ablation, cardiac surgery or presence of any prosthetic valves
- Use of amiodarone for any indication within 6 months prior to the planned ablation procedure
- Prior documented cavotricuspid isthmus dependent right atrial flutter and planned cavotricuspid isthmus ablation to be performed at the time of atrial fibrillation ablation
Other illness
- Any disease limiting life expectancy to \< 1year
- Myocardial infarction or percutaneous coronary intervention within 3 months preceding consent date
- Hypertrophic cardiomyopathy or other inherited cardiac condition
- Presence / likely implant of any pacemaker, cardiac resynchronization therapy device or implantable defibrillator within 1 year
- Use of any anti-arrhythmic drug for an arrhythmia indication other than atrial fibrillation
Lab values
- Contra-indication to MRI including renal dysfunction (eGFR\<30ml/min)
Other
- Any clinical contra-indication to ablation
- Potential participant currently pregnant or breast feeding
- Enrolment in an existing interventional atrial fibrillation study which alters treatment or follow-up.
- Unable to understand verbal or written explanations given in English or German as appropriate.
Who the study is looking for
- Symptomatic paroxysmal atrial fibrillation or persistent atrial fibrillation diagnosed - within 24 months preceding the consent date.
- Planned radiofrequency ablation for atrial fibrillation consisting of pulmonary vein isolation.
- Able and willing to comply with study follow-up requirements
- Able and willing to provide written informed consent
Age in the registry: 18 years to 80 years · Sex: All
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| NHS Lothian Coordinator of this site? Confirm its status | Edinburgh | United Kingdom | Unknown status |
| Guy's and St Thomas' NHS Foundation Trust Coordinator of this site? Confirm its status | London | United Kingdom | Unknown status |
Related publications
This page is information, not medical advice. Discuss any trial with your doctor.