NCT05058651RecruitingPhase 2/3
Evaluating the Addition of the Immunotherapy Drug Atezolizumab to Standard Chemotherapy Treatment for Advanced or Metastatic Neuroendocrine Carcinomas That Originate Outside the Lung
Randomized Phase II/III Trial of First Line Platinum/Etoposide With or Without Atezolizumab (NSC#783608) in Patients With Advanced or Metastatic Poorly Differentiated Extrapulmonary Neuroendocrine Carcinomas (NEC)
Source: ClinicalTrials.gov · Last updated 4 Nov 2026
Brief summary (registry, in English)
This phase II/III trial compares the effect of immunotherapy with atezolizumab in combination with standard chemotherapy with a platinum drug (cisplatin or carboplatin) and etoposide versus standard therapy alone for the treatment of poorly differentiated extrapulmonary (originated outside the lung) neuroendocrine cancer that may have spread from where it first started to nearby tissue, lymph nodes, or distant parts of the body (advanced) or that has spread from where it first started (primary site) to other places in the body (metastatic). The other aim of this trial is to compare using atezolizumab just at the beginning of treatment versus continuing it beyond the initial treatment. Immunotherapy with monoclonal antibodies, such as atezolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Cisplatin and carboplatin are in a class of medications known as platinum-containing compounds that work by killing, stopping or slowing the growth of cancer cells. Etoposide is in a class of medications known as podophyllotoxin derivatives. It blocks a certain enzyme needed for cell division and DNA repair, and it may kill cancer cells. Giving atezolizumab in combination with a platinum drug (cisplatin or carboplatin) and etoposide may work better in treating patients with poorly differentiated extrapulmonary neuroendocrine cancer compared to standard therapy with a platinum drug (cisplatin or carboplatin) and etoposide alone.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 2/3
- Study type
- Interventional
- Enrollment
- 189 (estimated)
- First submitted
- 25 Sept 2021
- Start date
- 28 Jun 2022
- Primary completion date
- 1 Oct 2028
- Lead sponsor
- National Cancer Institute (NCI)
- Diseases
- Neuroendocrine tumours
- NCT number
- NCT05058651
What you commit to
- Study type: Interventional · Phase 2/3
- Planned participants: 189
- From 28 Jun 2022 to the primary completion date, 1 Oct 2028
- 266 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Who the study is looking for
- Participants must have histologically-confirmed (local site pathological confirmation sufficient) extrapulmonary poorly differentiated, neuroendocrine carcinoma (NEC)
- Participants must have disease that is unresectable or metastatic and not eligible for definitive therapy as deemed per the treating investigator
- Participants must have radiologically evaluable disease, measurable or non-measurable, per Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 criteria. All measurable and nonmeasurable lesions must be assessed by CT scan with IV contrast of the chest/abdomen/and pelvis (or CT chest without contrast and MRI abdomen/pelvis with gadolinium contrast, if contraindication to CT iodinated contrast) within 28 days prior to registration. While may be used for routine clinical evaluation, PET scans and bone scans alone are not acceptable for disease assessment while participating in this study. All known sites of disease must be assessed and documented on the Baseline Tumor Assessment Form
- Participants must have brain MRI (or CT head with contrast if there is contraindication to MRI brain) if clinically indicated within 28 days prior to registration. Note: Brain imaging is not required in participants without known and/or clinical concern for brain metastases. Participants with asymptomatic central nervous system (CNS) metastases are eligible if one or more of the following apply:
- Participants who have received treatment for brain metastases must have:
- No evidence of radiological progression (by MRI brain or CT head with contrast if there is contraindication to MRI brain) within 28 days prior to registration
- Discontinued all corticosteroids at least 14 days prior to registration
- Participants with treatment-naive brain lesions must have:
- No lesion measuring \> 2.0 cm in size in any axis
- MRI brain or CT head with contrast (if there is contraindication to MRI brain) demonstrating no evidence for mass effect, edema, or other impending neurological compromise within 28 days prior to registration
- No evidence of radiological progression (by MRI brain or CT head with contrast if there is contraindication to MRI brain) within 28 days prior to registration
- No need for \> 2 mg of dexamethasone (or equivalent of \> 10 mg prednisone) per day at time of registration
- Participants must not have symptomatic central nervous system (CNS) metastases
- Participants must not have known or suspected leptomeningeal disease
- Participants with prior history of non-metastatic (localized/locally advanced disease) extrapulmonary poorly differentiated NEC may have had prior platinum-based therapy +/- radiation +/- surgery provided that all therapy was completed \>= 6 months prior to registration
- Participants must discontinue denosumab prior to study registration and plan to replace with a bisphosphonate while on the study
- Participants must not have had prior treatment for advanced or metastatic NEC EXCEPT one cycle of platinum (carboplatin/cisplatin) + etoposide is allowed prior to registration. Other chemotherapy regimens are not allowed. For participants with prostate or urothelial NEC, prior chemotherapy for the non-NEC component (e.g. adenocarcinoma or urothelial) is allowed as long as such therapy was completed \>= 24 weeks prior to registration and participants have recovered from all prior toxicities to =\< grade 1.
- Participants must not have had prior treatment with an anti-PD-1, anti-PD-L1, antiPD-L2, CD137 agonists, anti-CTLA-4 agent, or any other immune checkpoint inhibitors for any neuroendocrine neoplasm. Immune checkpoint inhibitors given for other cancer indications are allowed provided last therapy was given at least 12 months prior to study registration
- Participants must not have received treatment with systemic immunostimulatory agents including, but not limited to, interferon and interleukin2 \[IL-2\] within 4 weeks or 5 half-lives of the drug (whichever is longer) prior to registration
- Participants must not have had history of known severe allergy, anaphylactic, or other hypersensitivity reactions to chimeric or humanized antibodies, including to Chinese hamster ovary cell products or to any component of the atezolizumab formulation, cisplatin, carboplatin, or etoposide
- Participants must not be on active systemic therapy for another cancer with the exception of hormonal therapy including androgen deprivation therapy (e.g., gonadotropin-releasing hormone \[GnRH\] agonists or antagonists), which can be continued while participants are receiving protocol therapy. Use of enzalutamide or apalutamide is permitted after completion of chemotherapy and must be held during chemotherapy for participants receiving prior to enrollment. Use of darolutamide is permitted during chemotherapy. Glucocorticoid-containing regimens, including abiraterone, are not permitted.
- Participants must be \>= 18 years of age
- Participants must have a Zubrod performance status of =\< 2 within 28 days prior to registration
- Participants must have a complete medical history and physical exam within 28 days prior to registration
- Absolute neutrophil count (ANC) \>= 1.5 x 10\^9 /L (obtained within 14 days prior to registration. For participants who received a cycle of chemotherapy prior to registration, at least 21 days must have elapsed between day 1 of platinum + etoposide and performance of these tests)
- Hemoglobin \>= 9.0 g/dl (obtained within 14 days prior to registration. For participants who received a cycle of chemotherapy prior to registration, at least 21 days must have elapsed between day 1 of platinum + etoposide and performance of these tests)
- Platelet count \>= 100 x 10\^9/L (obtained within 14 days prior to registration. For participants who received a cycle of chemotherapy prior to registration, at least 21 days must have elapsed between day 1 of platinum + etoposide and performance of these tests)
- Serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =\< 2.5 x institutional upper limit of normal (ULN) (obtained within 14 days prior to registration. For participants who received a cycle of chemotherapy prior to registration, at least 21 days must have elapsed between day 1 of platinum + etoposide and performance of these tests)
- Serum total bilirubin =\< 1.5 x ULN (obtained within 14 days prior to registration. For participants who received a cycle of chemotherapy prior to registration, at least 21 days must have elapsed between day 1 of platinum + etoposide and performance of these tests)
- Adequate renal function as defined by any 1 of the following: 1) Measured creatinine clearance (CL) \> 50 mL/min OR 2) Calculated creatinine CL \> 50 mL/min by the Cockcroft-Gault formula OR by 24-hour urine collection for determination of creatinine clearance (obtained within 14 days prior to registration. For participants who received a cycle of chemotherapy prior to registration, at least 21 days must have elapsed between day 1 of platinum + etoposide and performance of these tests)
- Participants must not have uncontrolled or symptomatic hypercalcemia (\> 1.5 mmol/L ionized calcium or calcium \> 12 mg/dL or corrected serum calcium \> ULN) within 14 days prior to registration. Participants who have asymptomatic hypercalcemia are eligible provided that medical therapy to treat the hypercalcemia is planned
- Participants must not have a diagnosis of immunodeficiency nor be receiving systemic steroid therapy (equivalent of \> 20 mg of hydrocortisone per day) or any other form of immunosuppressive therapy within 14 days prior to registration
- Participants must not have active or history of autoimmune disease or immune deficiency, including, but not limited to myasthenia gravis, myositis, autoimmune hepatitis, systemic lupus erythematosus, rheumatoid arthritis, inflammatory bowel disease, antiphospholipid antibody syndrome, Wegener granulomatosis, Sjogren syndrome, Guillain-Barre syndrome, or multiple sclerosis with the following exceptions:
- Patients with a history of autoimmune-related hypothyroidism who are on thyroid-replacement hormone are eligible for the study
- Patients with controlled type 1 diabetes mellitus who are on an insulin regimen are eligible for the study
- Patients with eczema, psoriasis, lichen simplex chronicus, or vitiligo with dermatologic manifestations only (e.g., patients with psoriatic arthritis are excluded) are eligible for the study provided all of following conditions are met:
- Rash must cover \< 10% of body surface area
- Disease is well controlled at baseline and requires only low-potency topical corticosteroids
- No occurrence of acute exacerbations of the underlying condition requiring psoralen plus ultraviolet A radiation, methotrexate, retinoids, biologic agents, oral calcineurin inhibitors, or high-potency or oral corticosteroids within the previous 12 months
- Participants must not have history of idiopathic pulmonary fibrosis, organizing pneumonia (e.g., bronchiolitis obliterans), drug-induced pneumonitis, idiopathic pneumonitis, or evidence of active pneumonitis on screening chest CT scan. NOTE: History of radiation pneumonitis in the radiation field (fibrosis) is permitted
- Participants must not have significant cardiovascular disease, such as New York Heart Association class II or greater cardiac disease, myocardial infarction within 3 months prior to registration, unstable arrythmias, or unstable angina
- Participants must not have had a major surgical procedure other than for diagnosis within 28 days prior to registration. Participant must not plan to receive a major surgical procedure during the course of protocol treatment. NOTE: Patient port placement is not considered a major surgery
- Participants must not have severe infections (i.e., Common Terminology Criteria for Adverse Events \[CTCAE\] grade \>= 2) at time of registration, including but not limited to hospitalization for complications for infection, bacteremia, or severe pneumonia
- Participants must not have known active tuberculosis
- Participants with evidence of chronic hepatitis B virus (HBV) infection must have undetectable HBV viral load, with testing performed as clinically indicated
- Participants with a history of hepatitis C virus (HCV) infection must have been treated and cured. Participants with active HCV infection who are currently on treatment must have an undetectable HCV viral load, with testing performed as clinically indicated
- Participants with known human immunodeficiency virus (HIV)-infection must be on effective anti-retroviral therapy at time of registration and have undetectable HIV viral load within 6 months of registration
- Participants must not have prior allogeneic bone marrow transplantation or solid organ transplant
- Participants must not have received administration of a live, attenuated vaccine (e.g., FluMist \[registered trademark\]) within 28 days prior to initiation of study treatment, during treatment with atezolizumab, and not plan to receive for 5 months after the last dose of atezolizumab
- Participants must not be pregnant due to the possibility of harm to the fetus. Individuals who are of reproductive potential must have agreed to use an effective contraceptive method (with details provided as a part of the consent process) during the treatment period and for 5 months after the final dose of atezolizumab. A person who has had menses at any time in the preceding 12 consecutive months or who has semen likely to contain sperm is considered to be of "reproductive potential." In addition to routine contraceptive methods, "effective contraception" also includes refraining from sexual activity that might result in pregnancy and surgery intended to prevent pregnancy (or with a side effect of pregnancy prevention) including hysterectomy, bilateral oophorectomy, bilateral tubal ligation/occlusion, and vasectomy with testing showing no sperm in the semen
- Participants must be offered the opportunity to participate in specimen banking. With participant consent, specimens must be collected and submitted via the Southwest Oncology Group (SWOG) Specimen Tracking System
- Participants must be informed of the investigational nature of this study and must sign and give informed consent in accordance with institutional and federal guidelines
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (266)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Hawaii Cancer Care - Westridge Coordinator of this site? Confirm its status | ‘Aiea | United States | Recruiting |
| Pali Momi Medical Center Coordinator of this site? Confirm its status | ‘Aiea | United States | Suspended |
| Mary Greeley Medical Center Coordinator of this site? Confirm its status | Ames | United States | Recruiting |
| McFarland Clinic - Ames Coordinator of this site? Confirm its status | Ames | United States | Recruiting |
| Community Hospital of Anaconda Coordinator of this site? Confirm its status | Anaconda | United States | Recruiting |
| Kaiser Permanente-Anaheim Coordinator of this site? Confirm its status | Anaheim | United States | Recruiting |
| Alaska Women's Cancer Care Coordinator of this site? Confirm its status | Anchorage | United States | Suspended |
| UI Health Care Mission Cancer and Blood - Ankeny Clinic Coordinator of this site? Confirm its status | Ankeny | United States | Recruiting |
| Trinity Health Saint Joseph Mercy Hospital Ann Arbor Coordinator of this site? Confirm its status | Ann Arbor | United States | Recruiting |
| University of Michigan Rogel Cancer Center Coordinator of this site? Confirm its status | Ann Arbor | United States | Recruiting |
| Sutter Auburn Faith Hospital Coordinator of this site? Confirm its status | Auburn | United States | Recruiting |
| Sutter Cancer Centers Radiation Oncology Services-Auburn Coordinator of this site? Confirm its status | Auburn | United States | Recruiting |
| Rush-Copley Medical Center Coordinator of this site? Confirm its status | Aurora | United States | Suspended |
| Kaiser Permanente-Baldwin Park Coordinator of this site? Confirm its status | Baldwin Park | United States | Recruiting |
| LSU Health Baton Rouge-North Clinic Coordinator of this site? Confirm its status | Baton Rouge | United States | Recruiting |
| Our Lady of the Lake Physician Group Coordinator of this site? Confirm its status | Baton Rouge | United States | Recruiting |
| Bronson Battle Creek Coordinator of this site? Confirm its status | Battle Creek | United States | Recruiting |
| Kaiser Permanente-Bellflower Coordinator of this site? Confirm its status | Bellflower | United States | Recruiting |
| Saint Charles Health System Coordinator of this site? Confirm its status | Bend | United States | Recruiting |
| Alta Bates Summit Medical Center-Herrick Campus Coordinator of this site? Confirm its status | Berkeley | United States | Recruiting |
| Saint Vincent Frontier Cancer Center Coordinator of this site? Confirm its status | Billings | United States | Recruiting |
| Billings Clinic Cancer Center Coordinator of this site? Confirm its status | Billings | United States | Recruiting |
| McFarland Clinic - Boone Coordinator of this site? Confirm its status | Boone | United States | Suspended |
| United Hospital Center Coordinator of this site? Confirm its status | Bridgeport | United States | Recruiting |
| Trinity Health IHA Medical Group Hematology Oncology - Brighton Coordinator of this site? Confirm its status | Brighton | United States | Recruiting |
| Trinity Health Medical Center - Brighton Coordinator of this site? Confirm its status | Brighton | United States | Recruiting |
| Henry Ford Cancer Institute-Downriver Coordinator of this site? Confirm its status | Brownstown | United States | Recruiting |
| Roswell Park Cancer Institute Coordinator of this site? Confirm its status | Buffalo | United States | Active, not recruiting |
| Lahey Clinic Coordinator of this site? Confirm its status | Burlington | United States | Recruiting |
| Minnesota Oncology - Burnsville Coordinator of this site? Confirm its status | Burnsville | United States | Recruiting |
| Sutter Cancer Centers Radiation Oncology Services-Cameron Park Coordinator of this site? Confirm its status | Cameron Park | United States | Recruiting |
| Trinity Health Medical Center - Canton Coordinator of this site? Confirm its status | Canton | United States | Recruiting |
| Trinity Health IHA Medical Group Hematology Oncology - Canton Coordinator of this site? Confirm its status | Canton | United States | Recruiting |
| Saint Francis Medical Center Coordinator of this site? Confirm its status | Cape Girardeau | United States | Recruiting |
| Mercy San Juan Medical Center Coordinator of this site? Confirm its status | Carmichael | United States | Recruiting |
| Mercy Cancer Center - Carmichael Coordinator of this site? Confirm its status | Carmichael | United States | Recruiting |
| Saint Anthony Regional Hospital Coordinator of this site? Confirm its status | Carroll | United States | Recruiting |
| Duke Cancer Center Cary Coordinator of this site? Confirm its status | Cary | United States | Recruiting |
| Centralia Oncology Clinic Coordinator of this site? Confirm its status | Centralia | United States | Recruiting |
| WellSpan Medical Oncology and Hematology Coordinator of this site? Confirm its status | Chambersburg | United States | Recruiting |
| Medical University of South Carolina Coordinator of this site? Confirm its status | Charleston | United States | Suspended |
| Atrium Health Pineville/LCI-Pineville Coordinator of this site? Confirm its status | Charlotte | United States | Recruiting |
| Carolinas Medical Center/Levine Cancer Institute Coordinator of this site? Confirm its status | Charlotte | United States | Recruiting |
| Levine Cancer Institute-Ballantyne Coordinator of this site? Confirm its status | Charlotte | United States | Recruiting |
| Atrium Health University City/LCI-University Coordinator of this site? Confirm its status | Charlotte | United States | Recruiting |
| Levine Cancer Institute-SouthPark Coordinator of this site? Confirm its status | Charlotte | United States | Recruiting |
| Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital Coordinator of this site? Confirm its status | Chelsea | United States | Recruiting |
| Chelsea Hospital Coordinator of this site? Confirm its status | Chelsea | United States | Recruiting |
| Northwestern University Coordinator of this site? Confirm its status | Chicago | United States | Recruiting |
| University of Chicago Comprehensive Cancer Center Coordinator of this site? Confirm its status | Chicago | United States | Recruiting |
| Providence Cancer Institute Clackamas Clinic Coordinator of this site? Confirm its status | Clackamas | United States | Suspended |
| Southeastern Medical Oncology Center-Clinton Coordinator of this site? Confirm its status | Clinton | United States | Recruiting |
| Henry Ford Macomb Hospital-Clinton Township Coordinator of this site? Confirm its status | Clinton Township | United States | Recruiting |
| UI Health Care Mission Cancer and Blood - West Des Moines Clinic Coordinator of this site? Confirm its status | Clive | United States | Recruiting |
| Mercy Cancer Center-West Lakes Coordinator of this site? Confirm its status | Clive | United States | Recruiting |
| Kootenai Health - Coeur d'Alene Coordinator of this site? Confirm its status | Coeur d'Alene | United States | Recruiting |
| Ohio State University Comprehensive Cancer Center Coordinator of this site? Confirm its status | Columbus | United States | Recruiting |
| Atrium Health Cabarrus/LCI-Concord Coordinator of this site? Confirm its status | Concord | United States | Recruiting |
| Greater Regional Medical Center Coordinator of this site? Confirm its status | Creston | United States | Active, not recruiting |
| UChicago Medicine Northwest Indiana Coordinator of this site? Confirm its status | Crown Point | United States | Recruiting |
| Parkland Memorial Hospital Coordinator of this site? Confirm its status | Dallas | United States | Recruiting |
| UT Southwestern Simmons Cancer Center - RedBird Coordinator of this site? Confirm its status | Dallas | United States | Recruiting |
| UT Southwestern/Simmons Cancer Center-Dallas Coordinator of this site? Confirm its status | Dallas | United States | Recruiting |
| Carle at The Riverfront Coordinator of this site? Confirm its status | Danville | United States | Recruiting |
| Henry Ford Medical Center-Fairlane Coordinator of this site? Confirm its status | Dearborn | United States | Recruiting |
| Corewell Health Dearborn Hospital Coordinator of this site? Confirm its status | Dearborn | United States | Recruiting |
| Cancer Care Specialists of Illinois - Decatur Coordinator of this site? Confirm its status | Decatur | United States | Recruiting |
| Decatur Memorial Hospital Coordinator of this site? Confirm its status | Decatur | United States | Recruiting |
| Northwestern Medicine Cancer Center Kishwaukee Coordinator of this site? Confirm its status | DeKalb | United States | Recruiting |
| AdventHealth Porter Coordinator of this site? Confirm its status | Denver | United States | Recruiting |
| Smilow Cancer Hospital-Derby Care Center Coordinator of this site? Confirm its status | Derby | United States | Recruiting |
| UI Health Care Mission Cancer and Blood - Des Moines Clinic Coordinator of this site? Confirm its status | Des Moines | United States | Recruiting |
| Broadlawns Medical Center Coordinator of this site? Confirm its status | Des Moines | United States | Recruiting |
| Mercy Medical Center - Des Moines Coordinator of this site? Confirm its status | Des Moines | United States | Recruiting |
| UI Health Care Mission Cancer and Blood - Laurel Clinic Coordinator of this site? Confirm its status | Des Moines | United States | Recruiting |
| Iowa Methodist Medical Center Coordinator of this site? Confirm its status | Des Moines | United States | Recruiting |
| Wayne State University/Karmanos Cancer Institute Coordinator of this site? Confirm its status | Detroit | United States | Active, not recruiting |
| Henry Ford Hospital Coordinator of this site? Confirm its status | Detroit | United States | Recruiting |
| Henry Ford Health Saint John Hospital Coordinator of this site? Confirm its status | Detroit | United States | Recruiting |
| Saint Luke's Hospital of Duluth Coordinator of this site? Confirm its status | Duluth | United States | Active, not recruiting |
| Duke University Medical Center Coordinator of this site? Confirm its status | Durham | United States | Recruiting |
| Henry Ford River District Hospital Coordinator of this site? Confirm its status | East China Township | United States | Recruiting |
| Marshfield Medical Center-EC Cancer Center Coordinator of this site? Confirm its status | Eau Claire | United States | Recruiting |
| Fairview Southdale Hospital Coordinator of this site? Confirm its status | Edina | United States | Recruiting |
| Minnesota Oncology - Edina Coordinator of this site? Confirm its status | Edina | United States | Recruiting |
| Crossroads Cancer Center Coordinator of this site? Confirm its status | Effingham | United States | Recruiting |
| Carle Physician Group-Effingham Coordinator of this site? Confirm its status | Effingham | United States | Recruiting |
| Mercy Cancer Center - Elk Grove Coordinator of this site? Confirm its status | Elk Grove | United States | Recruiting |
| Ephrata Cancer Center Coordinator of this site? Confirm its status | Ephrata | United States | Recruiting |
| The Queen's Medical Center - West Oahu Coordinator of this site? Confirm its status | ‘Ewa Beach | United States | Recruiting |
| Smilow Cancer Hospital Care Center-Fairfield Coordinator of this site? Confirm its status | Fairfield | United States | Recruiting |
| Corewell Health Farmington Hills Hospital Coordinator of this site? Confirm its status | Farmington Hills | United States | Recruiting |
| Weisberg Cancer Treatment Center Coordinator of this site? Confirm its status | Farmington Hills | United States | Active, not recruiting |
| Cancer Hematology Centers - Flint Coordinator of this site? Confirm its status | Flint | United States | Recruiting |
| Genesys Hurley Cancer Institute Coordinator of this site? Confirm its status | Flint | United States | Recruiting |
| Hurley Medical Center Coordinator of this site? Confirm its status | Flint | United States | Recruiting |
| Genesee Hematology Oncology PC Coordinator of this site? Confirm its status | Flint | United States | Suspended |
| Kaiser Permanente-Fontana Coordinator of this site? Confirm its status | Fontana | United States | Recruiting |
| McFarland Clinic - Trinity Cancer Center Coordinator of this site? Confirm its status | Fort Dodge | United States | Recruiting |
| Holy Cross Hospital Coordinator of this site? Confirm its status | Fort Lauderdale | United States | Recruiting |
| UT Southwestern/Simmons Cancer Center-Fort Worth Coordinator of this site? Confirm its status | Fort Worth | United States | Recruiting |
| Palo Alto Medical Foundation-Fremont Coordinator of this site? Confirm its status | Fremont | United States | Recruiting |
| Levine Cancer Institute-Gaston Coordinator of this site? Confirm its status | Gastonia | United States | Recruiting |
| Northwestern Medicine Cancer Center Delnor Coordinator of this site? Confirm its status | Geneva | United States | Recruiting |
| Adams Cancer Center Coordinator of this site? Confirm its status | Gettysburg | United States | Recruiting |
| Smilow Cancer Hospital Care Center at Glastonbury Coordinator of this site? Confirm its status | Glastonbury | United States | Suspended |
| Northwestern Medicine Glenview Outpatient Center Coordinator of this site? Confirm its status | Glenview | United States | Recruiting |
| Southeastern Medical Oncology Center-Goldsboro Coordinator of this site? Confirm its status | Goldsboro | United States | Recruiting |
| Trinity Health Grand Rapids Hospital Coordinator of this site? Confirm its status | Grand Rapids | United States | Recruiting |
| Corewell Health Grand Rapids Hospitals - Butterworth Hospital Coordinator of this site? Confirm its status | Grand Rapids | United States | Recruiting |
| Northwestern Medicine Grayslake Outpatient Center Coordinator of this site? Confirm its status | Grayslake | United States | Recruiting |
| Benefis Sletten Cancer Institute Coordinator of this site? Confirm its status | Great Falls | United States | Recruiting |
| Smilow Cancer Hospital Care Center at Greenwich Coordinator of this site? Confirm its status | Greenwich | United States | Recruiting |
| Henry Ford Saint John Hospital - Van Elslander Coordinator of this site? Confirm its status | Grosse Pointe Woods | United States | Recruiting |
| Henry Ford Saint John Hospital - Academic Coordinator of this site? Confirm its status | Grosse Pointe Woods | United States | Recruiting |
| Henry Ford Saint John Hospital - Breast Coordinator of this site? Confirm its status | Grosse Pointe Woods | United States | Recruiting |
| Smilow Cancer Hospital Care Center - Guilford Coordinator of this site? Confirm its status | Guilford | United States | Recruiting |
| WellSpan Medical Oncology and Hematology Coordinator of this site? Confirm its status | Hanover | United States | Recruiting |
| Kaiser Permanente South Bay Coordinator of this site? Confirm its status | Harbor City | United States | Recruiting |
| Smilow Cancer Hospital Care Center at Saint Francis Coordinator of this site? Confirm its status | Hartford | United States | Suspended |
| Ingalls Memorial Hospital Coordinator of this site? Confirm its status | Harvey | United States | Recruiting |
| University of Hawaii Cancer Center Coordinator of this site? Confirm its status | Honolulu | United States | Recruiting |
| Queen's Cancer Center - Kuakini Coordinator of this site? Confirm its status | Honolulu | United States | Recruiting |
| Queen's Medical Center Coordinator of this site? Confirm its status | Honolulu | United States | Recruiting |
| Straub Clinic and Hospital Coordinator of this site? Confirm its status | Honolulu | United States | Recruiting |
| Queen's Cancer Cenrer - POB I Coordinator of this site? Confirm its status | Honolulu | United States | Recruiting |
| Hawaii Cancer Care Inc - Waterfront Plaza Coordinator of this site? Confirm its status | Honolulu | United States | Recruiting |
| Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center Coordinator of this site? Confirm its status | Houston | United States | Recruiting |
| Ben Taub General Hospital Coordinator of this site? Confirm its status | Houston | United States | Recruiting |
| Kaiser Permanente-Irvine Coordinator of this site? Confirm its status | Irvine | United States | Recruiting |
| Allegiance Health Coordinator of this site? Confirm its status | Jackson | United States | Recruiting |
| Mayo Clinic in Florida Coordinator of this site? Confirm its status | Jacksonville | United States | Recruiting |
| Southeastern Medical Oncology Center-Jacksonville Coordinator of this site? Confirm its status | Jacksonville | United States | Recruiting |
| McFarland Clinic - Jefferson Coordinator of this site? Confirm its status | Jefferson | United States | Suspended |
| Mercy Hospital Joplin Coordinator of this site? Confirm its status | Joplin | United States | Recruiting |
| West Michigan Cancer Center Coordinator of this site? Confirm its status | Kalamazoo | United States | Recruiting |
| Bronson Methodist Hospital Coordinator of this site? Confirm its status | Kalamazoo | United States | Recruiting |
| Logan Health Medical Center Coordinator of this site? Confirm its status | Kalispell | United States | Recruiting |
| Gundersen Lutheran Medical Center Coordinator of this site? Confirm its status | La Crosse | United States | Recruiting |
| Northwestern Medicine Lake Forest Hospital Coordinator of this site? Confirm its status | Lake Forest | United States | Recruiting |
| Karmanos Cancer Institute at McLaren Greater Lansing Coordinator of this site? Confirm its status | Lansing | United States | Active, not recruiting |
| Cancer Centers of Southwest Oklahoma Research Coordinator of this site? Confirm its status | Lawton | United States | Recruiting |
| Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center Coordinator of this site? Confirm its status | Lebanon | United States | Recruiting |
| Sechler Family Cancer Center Coordinator of this site? Confirm its status | Lebanon | United States | Recruiting |
| AdventHealth Littleton Coordinator of this site? Confirm its status | Littleton | United States | Recruiting |
| Trinity Health Saint Mary Mercy Livonia Hospital Coordinator of this site? Confirm its status | Livonia | United States | Recruiting |
| Kaiser Permanente West Los Angeles Coordinator of this site? Confirm its status | Los Angeles | United States | Recruiting |
| Kaiser Permanente Los Angeles Medical Center Coordinator of this site? Confirm its status | Los Angeles | United States | Recruiting |
| Henry Ford Warren Hospital - Breast Macomb Coordinator of this site? Confirm its status | Macomb | United States | Recruiting |
| Henry Ford Saint John Hospital - Macomb Medical Coordinator of this site? Confirm its status | Macomb | United States | Recruiting |
| McFarland Clinic - Marshalltown Coordinator of this site? Confirm its status | Marshalltown | United States | Recruiting |
| Marshfield Medical Center-Marshfield Coordinator of this site? Confirm its status | Marshfield | United States | Recruiting |
| Carle Physician Group-Mattoon/Charleston Coordinator of this site? Confirm its status | Mattoon | United States | Recruiting |
| East Jefferson General Hospital Coordinator of this site? Confirm its status | Metairie | United States | Recruiting |
| LSU Healthcare Network / Metairie Multi-Specialty Clinic Coordinator of this site? Confirm its status | Metairie | United States | Recruiting |
| Medical College of Wisconsin Coordinator of this site? Confirm its status | Milwaukee | United States | Recruiting |
| Hennepin County Medical Center Coordinator of this site? Confirm its status | Minneapolis | United States | Recruiting |
| Abbott-Northwestern Hospital Coordinator of this site? Confirm its status | Minneapolis | United States | Recruiting |
| Marshfield Medical Center - Minocqua Coordinator of this site? Confirm its status | Minocqua | United States | Recruiting |
| Community Medical Center Coordinator of this site? Confirm its status | Missoula | United States | Recruiting |
| Memorial Medical Center Coordinator of this site? Confirm its status | Modesto | United States | Recruiting |
| West Virginia University Healthcare Coordinator of this site? Confirm its status | Morgantown | United States | Recruiting |
| Palo Alto Medical Foundation-Camino Division Coordinator of this site? Confirm its status | Mountain View | United States | Recruiting |
| SSM Health Good Samaritan Coordinator of this site? Confirm its status | Mount Vernon | United States | Recruiting |
| Trinity Health Muskegon Hospital Coordinator of this site? Confirm its status | Muskegon | United States | Recruiting |
| Saint Alphonsus Cancer Care Center-Nampa Coordinator of this site? Confirm its status | Nampa | United States | Recruiting |
| Vanderbilt University/Ingram Cancer Center Coordinator of this site? Confirm its status | Nashville | United States | Recruiting |
| Providence Newberg Medical Center Coordinator of this site? Confirm its status | Newberg | United States | Recruiting |
| Yale University Coordinator of this site? Confirm its status | New Haven | United States | Recruiting |
| UC Comprehensive Cancer Center at Silver Cross Coordinator of this site? Confirm its status | New Lenox | United States | Recruiting |
| University Medical Center New Orleans Coordinator of this site? Confirm its status | New Orleans | United States | Recruiting |
| Mount Sinai Hospital Coordinator of this site? Confirm its status | New York | United States | Active, not recruiting |
| Corewell Health Lakeland Hospitals - Niles Hospital Coordinator of this site? Confirm its status | Niles | United States | Recruiting |
| Carle Cancer Institute Normal Coordinator of this site? Confirm its status | Normal | United States | Recruiting |
| Carle BroMenn Medical Center Coordinator of this site? Confirm its status | Normal | United States | Recruiting |
| Yale-New Haven Hospital North Haven Medical Center Coordinator of this site? Confirm its status | North Haven | United States | Recruiting |
| Cancer and Hematology Centers of Western Michigan - Norton Shores Coordinator of this site? Confirm its status | Norton Shores | United States | Suspended |
| Henry Ford Medical Center-Columbus Coordinator of this site? Confirm its status | Novi | United States | Recruiting |
| Cancer Care Center of O'Fallon Coordinator of this site? Confirm its status | O'Fallon | United States | Recruiting |
| Mercy Hospital Oklahoma City Coordinator of this site? Confirm its status | Oklahoma City | United States | Recruiting |
| University of Oklahoma Health Sciences Center Coordinator of this site? Confirm its status | Oklahoma City | United States | Recruiting |
| Kaiser Permanente-Ontario Coordinator of this site? Confirm its status | Ontario | United States | Recruiting |
| Providence Willamette Falls Medical Center Coordinator of this site? Confirm its status | Oregon City | United States | Recruiting |
| University of Chicago Medicine-Orland Park Coordinator of this site? Confirm its status | Orland Park | United States | Recruiting |
| Northwestern Medicine Orland Park Coordinator of this site? Confirm its status | Orland Park | United States | Recruiting |
| Palo Alto Medical Foundation Health Care Coordinator of this site? Confirm its status | Palo Alto | United States | Recruiting |
| Kaiser Permanente - Panorama City Coordinator of this site? Confirm its status | Panorama City | United States | Recruiting |
| AdventHealth Parker Coordinator of this site? Confirm its status | Parker | United States | Recruiting |
| Lahey Clinic Peabody Coordinator of this site? Confirm its status | Peabody | United States | Recruiting |
| Cancer Center at Saint Joseph's Coordinator of this site? Confirm its status | Phoenix | United States | Recruiting |
| Mayo Clinic Hospital in Arizona Coordinator of this site? Confirm its status | Phoenix | United States | Recruiting |
| FirstHealth of the Carolinas-Moore Regional Hospital Coordinator of this site? Confirm its status | Pinehurst | United States | Recruiting |
| Trinity Health Saint Joseph Mercy Oakland Hospital Coordinator of this site? Confirm its status | Pontiac | United States | Recruiting |
| Providence Saint Vincent Medical Center Coordinator of this site? Confirm its status | Portland | United States | Recruiting |
| Providence Portland Medical Center Coordinator of this site? Confirm its status | Portland | United States | Recruiting |
| Kootenai Clinic Cancer Services - Post Falls Coordinator of this site? Confirm its status | Post Falls | United States | Recruiting |
| Duke Cancer Center Raleigh Coordinator of this site? Confirm its status | Raleigh | United States | Recruiting |
| Rapid City Regional Hospital Coordinator of this site? Confirm its status | Rapid City | United States | Recruiting |
| Corewell Health Reed City Hospital Coordinator of this site? Confirm its status | Reed City | United States | Recruiting |
| Marshfield Medical Center-Rice Lake Coordinator of this site? Confirm its status | Rice Lake | United States | Recruiting |
| UT Southwestern Clinical Center at Richardson/Plano Coordinator of this site? Confirm its status | Richardson | United States | Recruiting |
| Kaiser Permanente-Riverside Coordinator of this site? Confirm its status | Riverside | United States | Recruiting |
| Mayo Clinic in Rochester Coordinator of this site? Confirm its status | Rochester | United States | Recruiting |
| UW Health Carbone Cancer Center Rockford Coordinator of this site? Confirm its status | Rockford | United States | Recruiting |
| Levine Cancer Institute-Rock Hill Coordinator of this site? Confirm its status | Rock Hill | United States | Recruiting |
| Mercy Cancer Center - Rocklin Coordinator of this site? Confirm its status | Rocklin | United States | Recruiting |
| Sutter Roseville Medical Center Coordinator of this site? Confirm its status | Roseville | United States | Recruiting |
| Sutter Cancer Centers Radiation Oncology Services-Roseville Coordinator of this site? Confirm its status | Roseville | United States | Recruiting |
| Corewell Health William Beaumont University Hospital Coordinator of this site? Confirm its status | Royal Oak | United States | Recruiting |
| Mercy Cancer Center - Sacramento Coordinator of this site? Confirm its status | Sacramento | United States | Recruiting |
| Sutter Medical Center Sacramento Coordinator of this site? Confirm its status | Sacramento | United States | Recruiting |
| Dartmouth Cancer Center - North Coordinator of this site? Confirm its status | Saint Johnsbury | United States | Recruiting |
| Corewell Health Lakeland Hospitals - Saint Joseph Hospital Coordinator of this site? Confirm its status | Saint Joseph | United States | Recruiting |
| Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center Coordinator of this site? Confirm its status | Saint Joseph | United States | Recruiting |
| Park Nicollet Clinic - Saint Louis Park Coordinator of this site? Confirm its status | Saint Louis Park | United States | Recruiting |
| United Hospital Coordinator of this site? Confirm its status | Saint Paul | United States | Recruiting |
| Regions Hospital Coordinator of this site? Confirm its status | Saint Paul | United States | Recruiting |
| Huntsman Cancer Institute/University of Utah Coordinator of this site? Confirm its status | Salt Lake City | United States | Recruiting |
| Kaiser Permanente-San Diego Zion Coordinator of this site? Confirm its status | San Diego | United States | Recruiting |
| Kootenai Clinic Cancer Services - Sandpoint Coordinator of this site? Confirm its status | Sandpoint | United States | Recruiting |
| California Pacific Medical Center-Pacific Campus Coordinator of this site? Confirm its status | San Francisco | United States | Recruiting |
| Kaiser Permanente-San Marcos Coordinator of this site? Confirm its status | San Marcos | United States | Recruiting |
| Palo Alto Medical Foundation-Santa Cruz Coordinator of this site? Confirm its status | Santa Cruz | United States | Recruiting |
| Sutter Pacific Medical Foundation Coordinator of this site? Confirm its status | Santa Rosa | United States | Recruiting |
| Fred Hutchinson Cancer Center Coordinator of this site? Confirm its status | Seattle | United States | Recruiting |
| University of Washington Medical Center - Montlake Coordinator of this site? Confirm its status | Seattle | United States | Recruiting |
| Saint Francis Regional Medical Center Coordinator of this site? Confirm its status | Shakopee | United States | Recruiting |
| Atrium Health Cleveland/LCI-Cleveland Coordinator of this site? Confirm its status | Shelby | United States | Recruiting |
| CoxHealth South Hospital Coordinator of this site? Confirm its status | Springfield | United States | Recruiting |
| Springfield Clinic Coordinator of this site? Confirm its status | Springfield | United States | Recruiting |
| Southern Illinois University School of Medicine Coordinator of this site? Confirm its status | Springfield | United States | Recruiting |
| Springfield Memorial Hospital Coordinator of this site? Confirm its status | Springfield | United States | Recruiting |
| Mercy Hospital Springfield Coordinator of this site? Confirm its status | Springfield | United States | Recruiting |
| Smilow Cancer Hospital Care Center at Long Ridge Coordinator of this site? Confirm its status | Stamford | United States | Recruiting |
| Marshfield Medical Center-River Region at Stevens Point Coordinator of this site? Confirm its status | Stevens Point | United States | Recruiting |
| Mercy Hospital South Coordinator of this site? Confirm its status | St Louis | United States | Recruiting |
| Stony Brook University Medical Center Coordinator of this site? Confirm its status | Stony Brook | United States | Active, not recruiting |
| Palo Alto Medical Foundation-Sunnyvale Coordinator of this site? Confirm its status | Sunnyvale | United States | Recruiting |
| Moffitt Cancer Center Coordinator of this site? Confirm its status | Tampa | United States | Recruiting |
| Toledo Clinic Cancer Centers-Toledo Coordinator of this site? Confirm its status | Toledo | United States | Suspended |
| Smilow Cancer Hospital-Torrington Care Center Coordinator of this site? Confirm its status | Torrington | United States | Recruiting |
| Munson Medical Center Coordinator of this site? Confirm its status | Traverse City | United States | Recruiting |
| Corewell Health Beaumont Troy Hospital Coordinator of this site? Confirm its status | Troy | United States | Recruiting |
| Smilow Cancer Hospital Care Center-Trumbull Coordinator of this site? Confirm its status | Trumbull | United States | Recruiting |
| Carle Cancer Center Coordinator of this site? Confirm its status | Urbana | United States | Recruiting |
| Sutter Solano Medical Center/Cancer Center Coordinator of this site? Confirm its status | Vallejo | United States | Recruiting |
| Henry Ford Health Warren Hospital Coordinator of this site? Confirm its status | Warren | United States | Recruiting |
| Henry Ford Madison Heights Hospital - Breast Coordinator of this site? Confirm its status | Warren | United States | Recruiting |
| Henry Ford Warren Hospital - GLCMS Coordinator of this site? Confirm its status | Warren | United States | Recruiting |
| Northwestern Medicine Cancer Center Warrenville Coordinator of this site? Confirm its status | Warrenville | United States | Recruiting |
| Smilow Cancer Hospital-Waterbury Care Center Coordinator of this site? Confirm its status | Waterbury | United States | Recruiting |
| Smilow Cancer Hospital Care Center - Waterford Coordinator of this site? Confirm its status | Waterford | United States | Recruiting |
| UI Health Care Mission Cancer and Blood - Waukee Clinic Coordinator of this site? Confirm its status | Waukee | United States | Recruiting |
| Henry Ford West Bloomfield Hospital Coordinator of this site? Confirm its status | West Bloomfield | United States | Recruiting |
| Mercy Medical Center-West Lakes Coordinator of this site? Confirm its status | West Des Moines | United States | Recruiting |
| Smilow Cancer Hospital Care Center - Westerly Coordinator of this site? Confirm its status | Westerly | United States | Recruiting |
| Marshfield Medical Center - Weston Coordinator of this site? Confirm its status | Weston | United States | Recruiting |
| Woodland Memorial Hospital Coordinator of this site? Confirm its status | Woodland | United States | Recruiting |
| Kaiser Permanente-Woodland Hills Coordinator of this site? Confirm its status | Woodland Hills | United States | Recruiting |
| Henry Ford Wyandotte Hospital Coordinator of this site? Confirm its status | Wyandotte | United States | Recruiting |
| University of Michigan Health - West Coordinator of this site? Confirm its status | Wyoming | United States | Recruiting |
| WellSpan Health-York Cancer Center Coordinator of this site? Confirm its status | York | United States | Recruiting |
| Cancer Care Associates of York Coordinator of this site? Confirm its status | York | United States | Suspended |
| Rush-Copley Healthcare Center Coordinator of this site? Confirm its status | Yorkville | United States | Suspended |
| Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus Coordinator of this site? Confirm its status | Ypsilanti | United States | Recruiting |
| Huron Gastroenterology PC Coordinator of this site? Confirm its status | Ypsilanti | United States | Recruiting |
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This page is information, not medical advice. Discuss any trial with your doctor.