NCT05062486CompletedPhase 2
A Study to Evaluate the Safety and Efficacy of RQC for AMD
An Open-Label, Randomized, Double Arm, Phase 2 Study to Evaluate the Safety and Efficacy of C and RQC for Preventing Progression in Age-Related Macular Degeneration
Source: ClinicalTrials.gov · Last updated 30 Jul 2025
Brief summary (registry, in English)
To evaluate the safety and efficacy of resveratrol, quercetin, and curcumin in combination (RQC) over 2 years in patients with age-related macular degeneration (AMD).
- Status (registry)
- Completed
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 55 (actual)
- First submitted
- 8 Sept 2021
- Start date
- 4 Oct 2021
- Primary completion date
- 7 Nov 2024
- Lead sponsor
- Paul A Knepper, MD PhD
- Diseases
- Macular degeneration
- NCT number
- NCT05062486
What you commit to
- Study type: Interventional · Phase 2
- Participants enrolled: 55
- From 4 Oct 2021 to the primary completion date, 7 Nov 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Participation in another clinical study with an investigational product during the last 90 days.
- Previous retinal or other ocular surgical procedures (other than cataract extraction) that may have complicated assessment of the progression of AMD.
- Use of any anticoagulant medication within 5 days before the first dose of investigative product is scheduled or required for subsequent medical treatment in the course of the study.
- History of known allergy to any component of the investigational product.
- Preplanned surgery or procedures that would interfere with the conduct of the study.
Other illness
- The presence of ocular disease or condition that may confound evaluation of the retina or could require medical or surgical intervention.
- A serious or complex systemic medical disease or condition with a poor five-year survival prognosis or that would make adherence or follow-up difficult or unlikely.
- Diagnosis of Alzheimer's disease or dementia, diagnosis of a serious gastrointestinal or stomach condition, or positive for HIV, hepatitis B surface antigen, or hepatitis C antibodies.
- History of inherited bleeding disorder.
- History of or a reason to believe participant has a history of drug or alcohol abuse within the past 5 years.
Lab values
- Clinically significant abnormal physical examination/vital signs or laboratory and coagulation blood tests as deemed appropriate by the investigator.
Other
- The presence of wet AMD.
- Currently incarcerated prisoners.
- Currently pregnant or lactating.
Who the study is looking for
- Male or female of any race or ethnicity.
- Aged 50-90 years at time of study entry.
- Ability to speak, read, and understand English.
- Ability to take oral medication and be willing to adhere to the study regimen.
- Capable of providing informed consent/provision of signed and dated informed consent.
- Stated willingness to comply with all procedures and availability for the duration of the study.
- Diagnosis of dry AMD (AREDS categories Early, drusen 63-124 µm in width; Intermediate, drusen ≥125 µm in width; or Advanced, macular geographic atrophy) as documented by OCT and/or color retinal photography.
Age in the registry: 50 years to 90 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Zaparackas M.D. & Knepper M.D. Ph.D., Ltd Coordinator of this site? Confirm its status | Chicago | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.