NCT05063552Active, not recruitingPhase 2/3
Testing the Use of Investigational Drugs Atezolizumab and/or Bevacizumab With or Without Standard Chemotherapy in the Second-Line Treatment of Advanced-Stage Head and Neck Cancers
A Phase II/III Trial of Chemotherapy + Cetuximab vs Chemotherapy + Bevacizumab vs Atezolizumab + Bevacizumab Following Progression on Immune Checkpoint Inhibition in Recurrent/Metastatic Head and Neck Cancers
Source: ClinicalTrials.gov · Last updated 3 Nov 2026
Brief summary (registry, in English)
This phase II/III compares the standard therapy (chemotherapy plus cetuximab) versus adding bevacizumab to standard chemotherapy, versus combination of just bevacizumab and atezolizumab in treating patients with head and neck cancer that has spread to other places in the body (metastatic or advanced stage) or has come back after prior treatment (recurrent). Immunotherapy with monoclonal antibodies, such as atezolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Bevacizumab is in a class of medications called antiangiogenic agents. It works by stopping the formation of blood vessels that bring oxygen and nutrients to tumor. This may slow the growth and spread of tumor. Cetuximab is in a class of medications called monoclonal antibodies. It binds to a protein called EGFR, which is found on some types of cancer cells. This may help keep cancer cells from growing. Cisplatin and carboplatin are in a class of chemotherapy medications known as platinum-containing compounds. They work by killing, stopping, or slowing the growth of cancer cells. Docetaxel is in a class of chemotherapy medications called taxanes. It stops cancer cells from growing and dividing and may kill them. The addition of bevacizumab to standard chemotherapy or combination therapy with bevacizumab and atezolizumab may be better than standard chemotherapy plus cetuximab in treating patients with recurrent/metastatic head and neck cancers.
- Status (registry)
- Active, not recruiting
- Phase (registry)
- Phase 2/3
- Study type
- Interventional
- Enrollment
- 430 (estimated)
- First submitted
- 30 Sept 2021
- Start date
- 13 Mar 2023
- Primary completion date
- 15 Dec 2027
- Lead sponsor
- National Cancer Institute (NCI)
- Diseases
- Head and neck cancer
- NCT number
- NCT05063552
What you commit to
- Study type: Interventional · Phase 2/3
- Planned participants: 430
- From 13 Mar 2023 to the primary completion date, 15 Dec 2027
- 172 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Who the study is looking for
- Patient must have histologically confirmed squamous cell carcinoma of the head and neck (HNSCC) (excluding squamous cell carcinoma \[SCC\] of salivary glands, Epstein-Barr virus \[EBV\]-associated nasopharynx and skin)
- Patient must have measurable disease as defined by Response Evaluation Criteria in Solid Tumors (RECIST) version (v)1.1. Measurements must be obtained within 4 weeks prior to randomization
- Patient must be \>= 18 years of age
- Patient must have an Eastern Cooperative Oncology Group (ECOG) performance status 0-1
- Patient must have disease progression after prior therapy with an immune checkpoint inhibitor (ICI) in the first-line setting for recurrent/metastatic disease. Patient must have received first-line immune checkpoint inhibition for at least 6 weeks. Patients who have recurred or progressed within 12 weeks of immune checkpoint inhibition administered in the definitive setting for locally advanced disease (for e.g., in the context of a clinical trial) will also be eligible if local therapies are not feasible
- Prior combination immunotherapies are permitted, but patient must not have had prior antiangiogenic treatment (e.g., bevacizumab, ziv-aflibercept, ramucirumab, sorafenib, sunitinib, pazopanib, regorafenib, lenvatinib, etc.). Patient must have completed any prior investigational therapy at least 28 days prior to randomization.
- NOTE: Patients who received platinum/taxanes in the locally-advanced or recurrent/metastatic setting and did not progress for at least 4 months thereafter, will be eligible for this study. Patients who received cetuximab in the locally-advanced setting and did not progress for at least 4 months thereafter, will also be eligible for this study
- Patient must not have a history of \>= grade 3 immune-related adverse event on prior ICI therapy (except those that could be managed with steroids \[e.g., dermatologic toxicity, asymptomatic elevation of pancreatic enzymes, etc.\]) and ICI could eventually be resumed. Patients who developed grade 3 endocrinopathies but are now stable on hormone supplementation and/or a daily prednisone dose of =\< 10 mg (or equivalent doses of another glucocorticoid), will be permitted on this trial
- Patient must not have a history of PD-1 inhibitor-induced hyper-progression, defined as 100% increase in tumor burden within 8 weeks (or 50% within 4 weeks) of initiating ICI and associated with clinical deterioration
- Patient must not have any of the following criteria due to the possibility of increased risk for tumor bleeding with bevacizumab therapy:
- Prior carotid bleeding,
- Tumors that invade major vessels (e.g., the carotid) as shown unequivocally by imaging studies,
- Central (e.g., within 2 cm from the hilum) lung metastases that are cavitary as shown unequivocally by imaging studies,
- Any prior history of bleeding related to the current head and neck cancer,
- History of gross hemoptysis (bright red blood of 1/2 teaspoon or more per episode of coughing) within 3 months prior to randomization
- Patient must not have uncontrolled hypertension, a history of hypertensive crisis or hypertensive encephalopathy, or a history of grade 4 thromboembolism
- Patient must not have a history of coagulopathy or hemorrhagic disorders
- Patient must not have a history of thrombosis (e.g., pulmonary embolism or deep venous thrombosis) currently requiring therapeutic anticoagulation (prophylactic use of anticoagulation is allowed)
- Patient must not be receiving chronic daily treatment with aspirin (\> 325 mg/day) or non-steroidal anti-inflammatory agents (NSAID's) known to inhibit platelet function. The use of anti-platelet agents \[e.g., dipyridamole (Persatine), ticlopidine (Ticlid), clopidogrel (Plavix)\] is allowed only if patient is not receiving concurrent aspirin or NSAID's known to inhibit platelet function
- Patient must have PD-L1 expression \>= 1% by CPS in the tumor and/or immune cells
- NOTE: Enrolling centers should test for PD-L1 CPS preferably using the SP263 assay. Where this is not feasible, using their preferred Clinical Laboratory Improvement Act (CLIA)-certified or similar assay will be accepted. It is preferred for standard of care (SOC) PD-L1 assessments to be done on post-first line ICI samples if available, but SOC PD-L1 assessments on pre-ICI samples will be accepted for eligibility
- Patient must not have a severe infection within 4 weeks prior to randomization, including, but not limited to, hospitalization for complications of infection, bacteremia, or severe pneumonia. Patients must not have active tuberculosis
- Patient must not have a history of non-infectious pneumonitis requiring steroids at doses greater than or equal to 10 mg per day of prednisone or the equivalent on first line immunotherapy
- Patient must not have a history of solid organ transplantation or stem-cell transplant
- Patient must not be on immunosuppressive medication within 7 days prior to randomization except for: intranasal, inhaled, or topical steroids, local steroid injection, systemic corticosteroids at doses less than or equal to 10 mg per day of prednisone or the equivalent, or steroids used as premedication for hypersensitivity reactions
- Patient must not have an active autoimmune disease that requires systemic treatment within 2 years prior to randomization. Patients who are receiving replacement therapy for adrenal or pituitary insufficiency will not be excluded
- Patient must not have had a severe hypersensitivity reaction to any of the drug components used on this protocol or to chimeric or humanized antibodies or fusion proteins
- Patient must not have received any live vaccine within 30 days prior to randomization and while participating in the study (and continue for 5 months after the last dose of atezolizumab on Arm C). Live vaccines include, but are not limited to, the following: measles, mumps, rubella, chicken pox, yellow fever, rabies, bacillus Calmette-Guerin (BCG), and typhoid (oral) vaccine. Patients are permitted to receive inactivated vaccines and any non-live vaccines including those for the seasonal influenza and coronavirus disease 2019 (COVID-19) (Note: intranasal influenza vaccines, such as Flu-Mist \[registered trademark\] are live attenuated vaccines and are not allowed). If possible, it is recommended to separate study drug administration from vaccine administration by about a week (primarily, in order to minimize an overlap of adverse events
- Patient must not be pregnant or breast-feeding due to the potential harm to an unborn fetus and possible risk for adverse events in nursing infants with the treatment regimens being used.
- All patients of childbearing potential must have a blood test or urine study within 14 days prior to randomization to rule out pregnancy.
- A patient of childbearing potential is defined as anyone, regardless of sexual orientation or whether they have undergone tubal ligation, who meets the following criteria: 1) has achieved menarche at some point, 2) has not undergone a hysterectomy or bilateral oophorectomy; or 3) has not been naturally postmenopausal (amenorrhea following cancer therapy does not rule out childbearing potential) for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months)
- Patients must not expect to conceive or father children by using accepted and effective method(s) of contraception or by abstaining from sexual intercourse for the duration of their participation in the study and for 2 months after the last dose of treatment for patients assigned to Arm A and for 6 months after the last dose of protocol treatment for patients assigned to Arms B or C.
- NOTE: Patients must also not breastfeed while on treatment and for 2 months after the last dose of treatment for patients assigned to Arm A and for 6 months after the last dose of treatment for patients assigned to Arms B or C
- Patient must have the ability to understand and the willingness to sign a written informed consent document. Patients with impaired decision-making capacity (IDMC) who have a legally authorized representative (LAR) or caregiver and/or family member available will also be considered eligible
- Leukocytes \>= 3,000/mcL (must be obtained =\< 14 days prior to protocol randomization)
- Absolute neutrophil count (ANC) \>= 1,500/mcL (must be obtained =\< 14 days prior to protocol randomization)
- Platelets \>= 100,000/mcL (must be obtained =\< 14 days prior to protocol randomization)
- Hemoglobin (Hgb) \> 9 g/dL (must be obtained =\< 14 days prior to protocol randomization) (Note: Patient may be transfused to meet this criteria)
- Total bilirubin =\< 2.0 x institutional upper limit of normal (ULN) (=\< 5.0 x institutional ULN if hepatic metastases present or =\< 3 x ULN for patients with known Gilbert's disease) (must be obtained =\< 14 days prior to protocol randomization)
- Aspartate aminotransferase (AST) (serum glutamic-oxaloacetic transaminase \[SGOT\]) and alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase \[SGPT\]) =\< 2.5 x institutional ULN (\< 5.0 x institutional ULN if hepatic metastases present) (must be obtained =\< 14 days prior to protocol randomization)
- Alkaline phosphatase \< 2.5 x institutional ULN (\< 5.0 x institutional ULN if hepatic or bone metastases present) (must be obtained =\< 14 days prior to protocol randomization)
- Creatinine =\< 1.5 x institutional ULN (must be obtained =\< 14 days prior to protocol randomization)
- Patients with uncontrolled or symptomatic hypercalcemia (ionized calcium \> 1.5 mmol/L, calcium \> 12 mg/dL or corrected serum calcium \> ULN) must have their calcium levels corrected prior to randomization
- Human immunodeficiency virus (HIV)-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months of randomization are eligible for this trial
- For patients with evidence of chronic hepatitis B virus (HBV) infection, the HBV viral load must be undetectable on suppressive therapy, if indicated
- Patients with a history of hepatitis C virus (HCV) infection must have been treated and cured. For patients with HCV infection who are currently on treatment, they are eligible if they have an undetectable HCV viral load
- Patients with treated brain metastases are eligible if follow-up brain imaging after central nervous system (CNS)-directed therapy shows no evidence of progression. Patients must not have untreated brain metastases or leptomeningeal disease
- Patients with a prior or concurrent malignancy whose natural history or treatment does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen are eligible for this trial
- Patients must not have uncontrolled pleural effusion, pericardial effusion, or ascites requiring recurrent drainage procedures (once monthly or more frequently). Patients may have indwelling catheters (e.g., PleurX \[registered trademark\])
- Patient must not have significant cardiovascular disease (such as New York Heart Association class II or greater cardiac disease, myocardial infarction, or cerebrovascular accident) within 3 months prior to randomization, or unstable arrhythmia or unstable angina at the time of randomization
- Patient must not receive any other chemotherapy, immunotherapy, antitumor hormonal therapy (excluding contraceptives and replacement steroids), radiation therapy, or experimental medications while on protocol treatment. Symptomatic lesions (e.g., bone metastases or metastases causing nerve impingement) amenable to palliative radiotherapy should be treated prior to randomization and patients must be recovered from the effects of radiation (there is no required minimum recovery period
- Patient must not have had a surgical procedure (including open biopsy, surgical resection, wound revision, or any other major surgery involving entry into a body cavity) or significant traumatic injury within 28 days prior to randomization, or anticipation of need for major surgical procedure while on protocol treatment
- Patient must not have any other disease, metabolic dysfunction, physical examination finding, or clinical laboratory finding that contraindicates the use of the agents used in this protocol, may affect the interpretation of the results, or may render the patient at high risk from treatment complications
- Patient must not have a history of abdominal fistula, gastrointestinal (GI) perforation, intra-abdominal abscess, or active GI bleeding within 6 months prior to randomization
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (172)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Hawaii Cancer Care - Westridge Coordinator of this site? Confirm its status | ‘Aiea | United States | Unknown status |
| University of New Mexico Cancer Center Coordinator of this site? Confirm its status | Albuquerque | United States | Unknown status |
| UPMC Altoona Coordinator of this site? Confirm its status | Altoona | United States | Unknown status |
| McFarland Clinic - Ames Coordinator of this site? Confirm its status | Ames | United States | Unknown status |
| Mary Greeley Medical Center Coordinator of this site? Confirm its status | Ames | United States | Unknown status |
| Community Hospital of Anaconda Coordinator of this site? Confirm its status | Anaconda | United States | Unknown status |
| UI Health Care Mission Cancer and Blood - Ankeny Clinic Coordinator of this site? Confirm its status | Ankeny | United States | Unknown status |
| Emory University Hospital/Winship Cancer Institute Coordinator of this site? Confirm its status | Atlanta | United States | Unknown status |
| Emory University Hospital Midtown Coordinator of this site? Confirm its status | Atlanta | United States | Unknown status |
| Rush-Copley Medical Center Coordinator of this site? Confirm its status | Aurora | United States | Unknown status |
| Johns Hopkins University/Sidney Kimmel Cancer Center Coordinator of this site? Confirm its status | Baltimore | United States | Unknown status |
| Greater Baltimore Medical Center Coordinator of this site? Confirm its status | Baltimore | United States | Unknown status |
| University of Maryland/Greenebaum Cancer Center Coordinator of this site? Confirm its status | Baltimore | United States | Unknown status |
| UPMC-Heritage Valley Health System Beaver Coordinator of this site? Confirm its status | Beaver | United States | Unknown status |
| Billings Clinic Cancer Center Coordinator of this site? Confirm its status | Billings | United States | Unknown status |
| Saint Luke's Cancer Institute - Boise Coordinator of this site? Confirm its status | Boise | United States | Unknown status |
| McFarland Clinic - Boone Coordinator of this site? Confirm its status | Boone | United States | Unknown status |
| Bozeman Health Deaconess Hospital Coordinator of this site? Confirm its status | Bozeman | United States | Unknown status |
| UPMC Hillman Cancer Center at Butler Health System Coordinator of this site? Confirm its status | Butler | United States | Unknown status |
| UPMC Camp Hill Coordinator of this site? Confirm its status | Camp Hill | United States | Unknown status |
| Saint Francis Medical Center Coordinator of this site? Confirm its status | Cape Girardeau | United States | Unknown status |
| Carlisle Regional Cancer Center Coordinator of this site? Confirm its status | Carlisle | United States | Unknown status |
| Miami Valley Hospital South Coordinator of this site? Confirm its status | Centerville | United States | Unknown status |
| Centralia Oncology Clinic Coordinator of this site? Confirm its status | Centralia | United States | Unknown status |
| Vandalia Health/CAMC Institute for Academic Medicine Coordinator of this site? Confirm its status | Charleston | United States | Unknown status |
| University of Illinois Coordinator of this site? Confirm its status | Chicago | United States | Unknown status |
| University of Chicago Comprehensive Cancer Center Coordinator of this site? Confirm its status | Chicago | United States | Unknown status |
| John H Stroger Jr Hospital of Cook County Coordinator of this site? Confirm its status | Chicago | United States | Unknown status |
| Providence Cancer Institute Clackamas Clinic Coordinator of this site? Confirm its status | Clackamas | United States | Unknown status |
| Southeastern Medical Oncology Center-Clinton Coordinator of this site? Confirm its status | Clinton | United States | Unknown status |
| UI Health Care Mission Cancer and Blood - West Des Moines Clinic Coordinator of this site? Confirm its status | Clive | United States | Unknown status |
| Mercy Cancer Center-West Lakes Coordinator of this site? Confirm its status | Clive | United States | Unknown status |
| Kootenai Health - Coeur d'Alene Coordinator of this site? Confirm its status | Coeur d'Alene | United States | Unknown status |
| Mercy Hospital Coordinator of this site? Confirm its status | Coon Rapids | United States | Unknown status |
| UM Sylvester Comprehensive Cancer Center at Coral Gables Coordinator of this site? Confirm its status | Coral Gables | United States | Unknown status |
| UPMC Hillman Cancer Center - Passavant - Cranberry Coordinator of this site? Confirm its status | Cranberry Township | United States | Unknown status |
| Greater Regional Medical Center Coordinator of this site? Confirm its status | Creston | United States | Unknown status |
| UPMC Western Maryland Coordinator of this site? Confirm its status | Cumberland | United States | Unknown status |
| Carle at The Riverfront Coordinator of this site? Confirm its status | Danville | United States | Unknown status |
| Dayton Physician LLC - Englewood Coordinator of this site? Confirm its status | Dayton | United States | Unknown status |
| Premier Blood and Cancer Center Coordinator of this site? Confirm its status | Dayton | United States | Unknown status |
| Miami Valley Hospital Coordinator of this site? Confirm its status | Dayton | United States | Unknown status |
| Miami Valley Hospital North Coordinator of this site? Confirm its status | Dayton | United States | Unknown status |
| Cancer Care Specialists of Illinois - Decatur Coordinator of this site? Confirm its status | Decatur | United States | Unknown status |
| Decatur Memorial Hospital Coordinator of this site? Confirm its status | Decatur | United States | Unknown status |
| UM Sylvester Comprehensive Cancer Center at Deerfield Beach Coordinator of this site? Confirm its status | Deerfield Beach | United States | Unknown status |
| Smilow Cancer Hospital-Derby Care Center Coordinator of this site? Confirm its status | Derby | United States | Unknown status |
| Mercy Medical Center - Des Moines Coordinator of this site? Confirm its status | Des Moines | United States | Unknown status |
| UI Health Care Mission Cancer and Blood - Laurel Clinic Coordinator of this site? Confirm its status | Des Moines | United States | Unknown status |
| UI Health Care Mission Cancer and Blood - Des Moines Clinic Coordinator of this site? Confirm its status | Des Moines | United States | Unknown status |
| Iowa Methodist Medical Center Coordinator of this site? Confirm its status | Des Moines | United States | Unknown status |
| Epic Care-Dublin Coordinator of this site? Confirm its status | Dublin | United States | Unknown status |
| Crossroads Cancer Center Coordinator of this site? Confirm its status | Effingham | United States | Unknown status |
| Carle Physician Group-Effingham Coordinator of this site? Confirm its status | Effingham | United States | Unknown status |
| Epic Care Partners in Cancer Care Coordinator of this site? Confirm its status | Emeryville | United States | Unknown status |
| UPMC Hillman Cancer Center Erie Coordinator of this site? Confirm its status | Erie | United States | Unknown status |
| Smilow Cancer Hospital Care Center-Fairfield Coordinator of this site? Confirm its status | Fairfield | United States | Unknown status |
| UPMC Cancer Center at UPMC Horizon Coordinator of this site? Confirm its status | Farrell | United States | Unknown status |
| McFarland Clinic - Trinity Cancer Center Coordinator of this site? Confirm its status | Fort Dodge | United States | Unknown status |
| Broward Health Medical Center Coordinator of this site? Confirm its status | Fort Lauderdale | United States | Unknown status |
| Atrium Medical Center-Middletown Regional Hospital Coordinator of this site? Confirm its status | Franklin | United States | Unknown status |
| Saint Luke's Cancer Institute - Fruitland Coordinator of this site? Confirm its status | Fruitland | United States | Unknown status |
| Smilow Cancer Hospital Care Center at Glastonbury Coordinator of this site? Confirm its status | Glastonbury | United States | Unknown status |
| Southeastern Medical Oncology Center-Goldsboro Coordinator of this site? Confirm its status | Goldsboro | United States | Unknown status |
| Benefis Sletten Cancer Institute Coordinator of this site? Confirm its status | Great Falls | United States | Unknown status |
| UPMC Cancer Centers - Arnold Palmer Pavilion Coordinator of this site? Confirm its status | Greensburg | United States | Unknown status |
| UPMC Hillman Cancer Center in Greenville/UPMC Horizon Coordinator of this site? Confirm its status | Greenville | United States | Unknown status |
| Miami Valley Cancer Care and Infusion Coordinator of this site? Confirm its status | Greenville | United States | Unknown status |
| Smilow Cancer Hospital Care Center at Greenwich Coordinator of this site? Confirm its status | Greenwich | United States | Unknown status |
| Smilow Cancer Hospital Care Center - Guilford Coordinator of this site? Confirm its status | Guilford | United States | Unknown status |
| UPMC Pinnacle Cancer Center/Community Osteopathic Campus Coordinator of this site? Confirm its status | Harrisburg | United States | Unknown status |
| Smilow Cancer Hospital Care Center at Saint Francis Coordinator of this site? Confirm its status | Hartford | United States | Unknown status |
| Ingalls Memorial Hospital Coordinator of this site? Confirm its status | Harvey | United States | Unknown status |
| Queen's Cancer Cenrer - POB I Coordinator of this site? Confirm its status | Honolulu | United States | Unknown status |
| Hawaii Cancer Care Inc - Waterfront Plaza Coordinator of this site? Confirm its status | Honolulu | United States | Unknown status |
| Queen's Medical Center Coordinator of this site? Confirm its status | Honolulu | United States | Unknown status |
| Queen's Cancer Center - Kuakini Coordinator of this site? Confirm its status | Honolulu | United States | Unknown status |
| IRMC Cancer Center Coordinator of this site? Confirm its status | Indiana | United States | Unknown status |
| UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care Coordinator of this site? Confirm its status | Irvine | United States | Unknown status |
| Southeastern Medical Oncology Center-Jacksonville Coordinator of this site? Confirm its status | Jacksonville | United States | Unknown status |
| McFarland Clinic - Jefferson Coordinator of this site? Confirm its status | Jefferson | United States | Unknown status |
| UPMC-Johnstown/John P. Murtha Regional Cancer Center Coordinator of this site? Confirm its status | Johnstown | United States | Unknown status |
| Kettering Medical Center Coordinator of this site? Confirm its status | Kettering | United States | Unknown status |
| Covenant Health Cancer Centers Coordinator of this site? Confirm its status | Knoxville | United States | Unknown status |
| Covenant Health Cancer Centers - West Coordinator of this site? Confirm its status | Knoxville | United States | Unknown status |
| Memorial Medical Center-Las Cruces Coordinator of this site? Confirm its status | Las Cruces | United States | Unknown status |
| Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center Coordinator of this site? Confirm its status | Lebanon | United States | Unknown status |
| Covenant Health Oncology Group - Lenoir City Coordinator of this site? Confirm its status | Lenoir City | United States | Unknown status |
| University of Arkansas for Medical Sciences Coordinator of this site? Confirm its status | Little Rock | United States | Unknown status |
| McFarland Clinic - Marshalltown Coordinator of this site? Confirm its status | Marshalltown | United States | Unknown status |
| Contra Costa Regional Medical Center Coordinator of this site? Confirm its status | Martinez | United States | Unknown status |
| Carle Physician Group-Mattoon/Charleston Coordinator of this site? Confirm its status | Mattoon | United States | Unknown status |
| UPMC Cancer Center at UPMC McKeesport Coordinator of this site? Confirm its status | McKeesport | United States | Unknown status |
| UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion Coordinator of this site? Confirm its status | Mechanicsburg | United States | Unknown status |
| Saint Luke's Cancer Institute - Meridian Coordinator of this site? Confirm its status | Meridian | United States | Unknown status |
| UM Sylvester Comprehensive Cancer Center at Kendall Coordinator of this site? Confirm its status | Miami | United States | Unknown status |
| University of Miami Miller School of Medicine-Sylvester Cancer Center Coordinator of this site? Confirm its status | Miami | United States | Unknown status |
| Abbott-Northwestern Hospital Coordinator of this site? Confirm its status | Minneapolis | United States | Unknown status |
| Hennepin County Medical Center Coordinator of this site? Confirm its status | Minneapolis | United States | Unknown status |
| Community Medical Center Coordinator of this site? Confirm its status | Missoula | United States | Unknown status |
| Forbes Hospital Coordinator of this site? Confirm its status | Monroeville | United States | Unknown status |
| UPMC Hillman Cancer Center - Monroeville Coordinator of this site? Confirm its status | Monroeville | United States | Unknown status |
| UPMC Hillman Cancer Center in Coraopolis Coordinator of this site? Confirm its status | Moon Township | United States | Unknown status |
| UPMC Hillman Cancer Center - Part of Frick Hospital Coordinator of this site? Confirm its status | Mount Pleasant | United States | Unknown status |
| ProHealth D N Greenwald Center Coordinator of this site? Confirm its status | Mukwonago | United States | Unknown status |
| Saint Luke's Cancer Institute - Nampa Coordinator of this site? Confirm its status | Nampa | United States | Unknown status |
| Vanderbilt University/Ingram Cancer Center Coordinator of this site? Confirm its status | Nashville | United States | Unknown status |
| UPMC Cancer Center-Natrona Heights Coordinator of this site? Confirm its status | Natrona Heights | United States | Unknown status |
| Medical Oncology Hematology Consultants PA Coordinator of this site? Confirm its status | Newark | United States | Unknown status |
| Helen F Graham Cancer Center Coordinator of this site? Confirm its status | Newark | United States | Unknown status |
| Providence Newberg Medical Center Coordinator of this site? Confirm its status | Newberg | United States | Unknown status |
| UPMC Hillman Cancer Center - New Castle Coordinator of this site? Confirm its status | New Castle | United States | Unknown status |
| Yale University Coordinator of this site? Confirm its status | New Haven | United States | Unknown status |
| UC Comprehensive Cancer Center at Silver Cross Coordinator of this site? Confirm its status | New Lenox | United States | Unknown status |
| University Medical Center New Orleans Coordinator of this site? Confirm its status | New Orleans | United States | Unknown status |
| Arnold Palmer Cancer Center Medical Oncology Norwin Coordinator of this site? Confirm its status | N. Huntingdon | United States | Unknown status |
| Yale-New Haven Hospital North Haven Medical Center Coordinator of this site? Confirm its status | North Haven | United States | Unknown status |
| Covenant Health Oncology Group - Oak Ridge Coordinator of this site? Confirm its status | Oak Ridge | United States | Unknown status |
| ProHealth Oconomowoc Memorial Hospital Coordinator of this site? Confirm its status | Oconomowoc | United States | Unknown status |
| HSHS Saint Elizabeth's Hospital Coordinator of this site? Confirm its status | O'Fallon | United States | Unknown status |
| Cancer Care Center of O'Fallon Coordinator of this site? Confirm its status | O'Fallon | United States | Unknown status |
| University of Oklahoma Health Sciences Center Coordinator of this site? Confirm its status | Oklahoma City | United States | Unknown status |
| Smilow Cancer Hospital-Orange Care Center Coordinator of this site? Confirm its status | Orange | United States | Unknown status |
| UC Irvine Health- Chao Family Comprehensive Cancer Center Coordinator of this site? Confirm its status | Orange | United States | Unknown status |
| University of Chicago Medicine-Orland Park Coordinator of this site? Confirm its status | Orland Park | United States | Unknown status |
| Stanford Cancer Institute Palo Alto Coordinator of this site? Confirm its status | Palo Alto | United States | Unknown status |
| VA Palo Alto Health Care System Coordinator of this site? Confirm its status | Palo Alto | United States | Unknown status |
| Jefferson Torresdale Hospital Coordinator of this site? Confirm its status | Philadelphia | United States | Unknown status |
| Thomas Jefferson University Hospital Coordinator of this site? Confirm its status | Philadelphia | United States | Unknown status |
| UPMC Hillman Cancer Center Coordinator of this site? Confirm its status | Pittsburgh | United States | Unknown status |
| Allegheny General Hospital Coordinator of this site? Confirm its status | Pittsburgh | United States | Unknown status |
| UPMC-Mercy Hospital Coordinator of this site? Confirm its status | Pittsburgh | United States | Unknown status |
| UPMC-Passavant Hospital Coordinator of this site? Confirm its status | Pittsburgh | United States | Unknown status |
| UPMC-Saint Clair Hospital Cancer Center Coordinator of this site? Confirm its status | Pittsburgh | United States | Unknown status |
| UPMC-Saint Margaret Coordinator of this site? Confirm its status | Pittsburgh | United States | Unknown status |
| UM Sylvester Comprehensive Cancer Center at Plantation Coordinator of this site? Confirm its status | Plantation | United States | Unknown status |
| Providence Portland Medical Center Coordinator of this site? Confirm its status | Portland | United States | Unknown status |
| Providence Saint Vincent Medical Center Coordinator of this site? Confirm its status | Portland | United States | Unknown status |
| Kootenai Clinic Cancer Services - Post Falls Coordinator of this site? Confirm its status | Post Falls | United States | Unknown status |
| Rapid City Regional Hospital Coordinator of this site? Confirm its status | Rapid City | United States | Unknown status |
| Dartmouth Cancer Center - North Coordinator of this site? Confirm its status | Saint Johnsbury | United States | Unknown status |
| Park Nicollet Clinic - Saint Louis Park Coordinator of this site? Confirm its status | Saint Louis Park | United States | Unknown status |
| Regions Hospital Coordinator of this site? Confirm its status | Saint Paul | United States | Unknown status |
| Kootenai Clinic Cancer Services - Sandpoint Coordinator of this site? Confirm its status | Sandpoint | United States | Unknown status |
| UPMC Cancer Center at UPMC Northwest Coordinator of this site? Confirm its status | Seneca | United States | Unknown status |
| Southern Illinois University School of Medicine Coordinator of this site? Confirm its status | Springfield | United States | Unknown status |
| Springfield Memorial Hospital Coordinator of this site? Confirm its status | Springfield | United States | Unknown status |
| Springfield Clinic Coordinator of this site? Confirm its status | Springfield | United States | Unknown status |
| Smilow Cancer Hospital Care Center at Long Ridge Coordinator of this site? Confirm its status | Stamford | United States | Unknown status |
| Trinity's Tony Teramana Cancer Center Coordinator of this site? Confirm its status | Steubenville | United States | Unknown status |
| Mercy Hospital South Coordinator of this site? Confirm its status | St Louis | United States | Unknown status |
| Toledo Clinic Cancer Centers-Toledo Coordinator of this site? Confirm its status | Toledo | United States | Unknown status |
| Smilow Cancer Hospital-Torrington Care Center Coordinator of this site? Confirm its status | Torrington | United States | Unknown status |
| Upper Valley Medical Center Coordinator of this site? Confirm its status | Troy | United States | Unknown status |
| Smilow Cancer Hospital Care Center-Trumbull Coordinator of this site? Confirm its status | Trumbull | United States | Unknown status |
| Saint Luke's Cancer Institute - Twin Falls Coordinator of this site? Confirm its status | Twin Falls | United States | Unknown status |
| UPMC Cancer Center-Uniontown Coordinator of this site? Confirm its status | Uniontown | United States | Unknown status |
| Carle Cancer Center Coordinator of this site? Confirm its status | Urbana | United States | Unknown status |
| UPMC Cancer Center-Washington Coordinator of this site? Confirm its status | Washington | United States | Unknown status |
| MedStar Washington Hospital Center Coordinator of this site? Confirm its status | Washington D.C. | United States | Unknown status |
| Smilow Cancer Hospital-Waterbury Care Center Coordinator of this site? Confirm its status | Waterbury | United States | Unknown status |
| Smilow Cancer Hospital Care Center - Waterford Coordinator of this site? Confirm its status | Waterford | United States | Unknown status |
| UI Health Care Mission Cancer and Blood - Waukee Clinic Coordinator of this site? Confirm its status | Waukee | United States | Unknown status |
| UW Cancer Center at ProHealth Care Coordinator of this site? Confirm its status | Waukesha | United States | Unknown status |
| Mercy Medical Center-West Lakes Coordinator of this site? Confirm its status | West Des Moines | United States | Unknown status |
| Smilow Cancer Hospital Care Center - Westerly Coordinator of this site? Confirm its status | Westerly | United States | Unknown status |
| UPMC West Mifflin-Cancer Center Jefferson Coordinator of this site? Confirm its status | West Mifflin | United States | Unknown status |
| Divine Providence Hospital Coordinator of this site? Confirm its status | Williamsport | United States | Unknown status |
| Asplundh Cancer Pavilion Coordinator of this site? Confirm its status | Willow Grove | United States | Unknown status |
| UMass Memorial Medical Center - University Campus Coordinator of this site? Confirm its status | Worcester | United States | Unknown status |
| UPMC Memorial Coordinator of this site? Confirm its status | York | United States | Unknown status |
| Rush-Copley Healthcare Center Coordinator of this site? Confirm its status | Yorkville | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.