NCT05077618Recruiting
Nalysis of the Periodontal Microbiota in Elderly Subjects With and Without Alzheimer's Disease: a Case Control Study
Oral Bacterial and Viral Mapping by Dental Plaque in Elderly Patients With and Without Alzheimer's Disease(ORal MICrobiology in Alzheimer's Patients)
Source: ClinicalTrials.gov · Last updated 20 Mar 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
The neurological disorders that accompany aging represent a major public health problem. The management of these diseases is a major medical and social priority. This project is based on the assumption that the oral cavity represents a privileged observation space to address these issues. The mouth is a site of easy access for painless sampling; there is therefore a major interest in identifying early oral infectious markers of the development or evolution of senile dementia. In addition to the interest of an early oral diagnosis, the mapping of the oral microbial flora in the demented elderly would allow a better understanding, prevention or even control of the evolution of neurodegenerative diseases. The final objective of our approach is to characterize the oral pathogens, or more probably the group of oral pathogens, which are significantly associated with Alzheimer's disease.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 94 (estimated)
- First submitted
- 1 Oct 2021
- Start date
- 30 Jan 2023
- Primary completion date
- 30 Jan 2023
- Lead sponsor
- Centre Hospitalier Universitaire de Nice
- Diseases
- Alzheimer disease
- NCT number
- NCT05077618
What you commit to
- Study type: Observational
- Planned participants: 94
- From 30 Jan 2023 to the primary completion date, 30 Jan 2023
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patients who have undergone oral surgery in the two months prior to sampling
- Patients treated with oral retinoids, bisphosphonates, oral anticoagulants or anticonvulsants
- A history of treatments (drugs and probiotics) taken in the month prior to sampling will be taken, as well as a record of toxic habits (tobacco, alcohol, other)
Other illness
- Presence of a neurodegenerative pathology (excluding Alzheimer's disease for cases)
- Presence of a neurocognitive disorder (excluding Alzheimer's disease for the cases)
- Patient with or having had any kind of cancer, including oral or aerodigestive tract
- Patients with or having had autoimmune diseases (HIV, hepatitis)
- Patients with inflammatory diseases (such as rheumatoid arthritis (RA) or Gougerot-Sjogren's syndrome (GSJ))
- Patients with severe acute or chronic cardiovascular, renal, hepatic, gastrointestinal, allergic, endocrine, pulmonary, neuropsychiatric pathologies, judged by the investigator to be incompatible with the study, as all these pathologies may interfere with the results of the oral flora sampling
- Patients who have had anti-cancer or immunosuppressive chemotherapy within the last 6 months
Other
- Patients with severe haemopathy
- Patient who has had antibiotic or anti-inflammatory treatment in the last 4 weeks
Who the study is looking for
- ge greater than or equal to 70 years old
- Patient (or trusted person) having read and understood the study information note and signed the informed consent form
- Membership in a social security scheme
- for cases : Diagnosis of possible or probable Alzheimer's disease according to the DSM-V
Age in the registry: 18 years to 90 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| CHU de Nice Coordinator of this site? Confirm its status | Nice | France | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.