NCT05085704Recruiting
Brain Metabolism Observed at 3 Tesla or 7 Tesla in Health and Metabolic Disease
Source: ClinicalTrials.gov · Last updated 1 Jun 2026
Brief summary (registry, in English)
The goal is to develop methodology to monitor flux in the citric acid cycle in brain via 13C nuclear magnetic resonance (NMR) spectroscopy at 7 Tesla or 3 Tesla.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 20 (estimated)
- First submitted
- 31 Aug 2021
- Start date
- 3 May 2022
- Primary completion date
- 1 Jun 2029
- Lead sponsor
- Weill Medical College of Cornell University
- Diseases
- Epilepsy
- NCT number
- NCT05085704
What you commit to
- Study type: Observational
- Planned participants: 20
- From 3 May 2022 to the primary completion date, 1 Jun 2029
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Subjects with typical implanted orthopedic metal in bone may be considered for inclusion in a 7T scan providing the implant is not within the volume of the radio frequency coil. The PI and the AIRC Medical Director will discuss each case and determine eligibility.
- Persons with questionable ferrous implants, bullets, BB's, and shrapnel will be excluded.
Other illness
- People or patients with uncontrolled seizure disorder, defined as grand mal (not absence) seizure in the preceding 3 months.
Lab values
- Pregnant females will be excluded. A serum or urine pregnancy test will be administered to all females of child bearing potential within 24 hours of administration of the tracer and MRI scan. The pregnancy test will be communicated in person by the study PI. Positive results in subjects 17 years old or younger will be disclosed to parent/guardian only.
Other
- Persons with ICD, pacemakers, neurostimulators and other such devices will be excluded.
- Persons with claustrophobia are excluded.
- Subjects who are not fluent in English will be excluded because immediate cooperation and the ability to respond to instructions from the investigators are necessary.
- People following a ketogenic diet
Who the study is looking for
- Subjects will be adolescents or adults, age 16-80 years in good general health (evidenced by normal vital signs and no acute signs or symptoms of illness) or with previously (not for this study) documented G1D (genetically confirmed).
- Ages 16 to 80
- Persons with dental fillings, dental crowns, and short (max.4 cm) dental retainer wires can be included.
Age in the registry: 16 years to 80 years · Sex: All · Accepts healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| UT Southwestern Medical Center Coordinator of this site? Confirm its status | Dallas | United States | Terminated |
| Weill Cornell Medicine Coordinator of this site? Confirm its status | New York | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.