NCT05091086Active, not recruitingPhase 4
The Optimal Long Term Treatment Strategy of Anti-resorptive Medications
Source: ClinicalTrials.gov · Last updated 22 May 2025
Brief summary (registry, in English)
This study is to investigate whether the alternating use of Prolia (Denosumab) and Aclasta (Zoledronic acid) can continue to increase bone density.
- Status (registry)
- Active, not recruiting
- Phase (registry)
- Phase 4
- Study type
- Interventional
- Enrollment
- 60 (estimated)
- First submitted
- 11 Oct 2021
- Start date
- 20 Nov 2021
- Primary completion date
- 31 Dec 2025
- Lead sponsor
- National Taiwan University Hospital
- Diseases
- Osteoporosis
- NCT number
- NCT05091086
What you commit to
- Study type: Interventional · Phase 4
- Planned participants: 60
- From 20 Nov 2021 to the primary completion date, 31 Dec 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Continuous steroid treatment, hormone therapy or other medical treatment affecting bone metabolism.
- Patients had ever used antiosteoporosis medications other than Dmab
Other illness
- Metabolic bone diseases.
- Malignancy.
- Allergy to Zoledronate.
- History of diagnosed hypocalcemia.
Age
- Age greater than 80 years.
Other
- Secondary osteoporosis.
- Estimated glomerular filtration rate \< 35 mL/min.
- Any other contraindications to Zoledronate use.
Who the study is looking for
- Postmenopausal women or men over 50 years old with osteoporosis or osteopenia leading to fractures.
- Denosumab treatment for at least two years and less than three years (up to maximum of five doses).
Age in the registry: 50 years to 80 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| National Taiwan University Hospital Yunlin Branch Coordinator of this site? Confirm its status | Douliu | Taiwan | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.