NCT05091099CompletedPhase 4
The Optimal Sequential Therapy After Long Term Denosumab Treatment
Source: ClinicalTrials.gov · Last updated 19 Nov 2025
Brief summary (registry, in English)
This study intends to investigate whether Alendronate and Zoledronate can prevent bone mineral density loss after long-term treatment with Denosumab.
- Status (registry)
- Completed
- Phase (registry)
- Phase 4
- Study type
- Interventional
- Enrollment
- 44 (actual)
- First submitted
- 11 Oct 2021
- Start date
- 10 Jan 2022
- Primary completion date
- 14 Nov 2025
- Lead sponsor
- National Taiwan University Hospital
- Diseases
- Osteoporosis
- NCT number
- NCT05091099
What you commit to
- Study type: Interventional · Phase 4
- Participants enrolled: 44
- From 10 Jan 2022 to the primary completion date, 14 Nov 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Ongoing systemic glucocorticoid therapy
- Current use of hormone replacement therapy
- Current use of any medication known to affect bone metabolism
- Prior use of any osteoporosis medication other than denosumab
Other illness
- Metabolic bone diseases
- Active or prior malignancy
- Known hypersensitivity to zoledronic acid
Lab values
- Estimated glomerular filtration rate (eGFR) \< 40 mL/min
Age
- Age \> 85 years
Other
- Secondary osteoporosis
- Hypocalcemia
- Any other contraindication to zoledronic acid
- Esophageal abnormalities that delay esophageal emptying (e.g., esophageal stricture, achalasia)
- Inability to stand or sit upright for at least 30 minutes
Who the study is looking for
- Postmenopausal women or men over 50 years old
- Continuous Denosumab treatment for at least three years (up to six doses).
Age in the registry: 50 years to 85 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| National Taiwan University Hospital Yunlin Branch Coordinator of this site? Confirm its status | Douliu | Taiwan | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.