NCT05091268Active, not recruiting
Effect of Physical Activity and Pain Education on Endometriosis-associated Pain
Effect of Physical Activity and Pain Education on Endometriosis-associated Pain A Randomizes Controlled Trial With a Multimodal Interdisciplinary Group Approach
Source: ClinicalTrials.gov · Last updated 30 Jul 2025
Brief summary (registry, in English)
Endometriosis is a benign gynecological condition where the uterine endometrium is located outside the uterus. The condition affects up to 10% of women of fertile age and up to 70% of women with endometriosis have symptoms with severe pain during menstruation (dysmenorrhea), pain during intercourse (dyspareunia), and/or chronic pelvic pain. Current treatments are dictated by the primary symptom: pain and are limited to surgery and hormonal treatments with often short-lived effects. Advances in the understanding of the condition have expanded to focus on less invasive and non-pharmacological treatments. Systematic reviews and meta-analyses of observational studies have focused on the protective role of physical activity and exercise on the risk of developing endometriosis. The results from these studies have been inconclusive. However, the efficacy of physical activity and exercise on pain among women with endometriosis has not been tested in high-quality randomized controlled trials (RCT).
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 83 (actual)
- First submitted
- 23 Sept 2021
- Start date
- 15 Feb 2022
- Primary completion date
- 1 Mar 2026
- Lead sponsor
- University Hospital, Akershus
- Diseases
- Endometriosis
- NCT number
- NCT05091268
What you commit to
- Study type: Interventional
- Participants enrolled: 83
- From 15 Feb 2022 to the primary completion date, 1 Mar 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Intra-abdominal or vaginal surgery in the last six months
- Patients who have received Botox over the past four months
- Participants who have recently undergone surgery and received Botox injections into the pelvic area can be referred but must wait 4-6 months before being included in the study. Women with planned surgery or Botox in the study period will be excluded.
- Participants recently started or adjusting ongoing hormonal therapy must wait 3-6 months to be included in the study.
Other illness
- Severe pathology (malignancy),cardiovascular conditions and immune system diseases diagnosed by specialist; pregnancy, as well as childbirth the last 12 months and breastfeeding; severe psychiatric disorders that demands or has demanded admission to the hospital; personality disorder diagnosed by specialist and recently started or recently adjusted ongoing hormonal therapy.
- Participants should not have any disease or injury that could prevent them from participating in the intervention.
Other
- Participants will be encouraged not to start with any new treatment (non-pharmacological or pharmacological) during the four-month intervention period.
Who the study is looking for
- Women of age 18-45 with signs of endometriosis on ultrasound and/or MRI and/or confirmed by laparoscopy with histology at Akershus University Hospital and Oslo University Hospital. Women may also be recruited through social media but must present with diagnosis of endometriosis.
- genital-pelvic pain ≥4/10 as measured on a numeric rating scale.
- able to understand and speak Norwegian language
- able to meet at Akershus University Hospital for participation in the study
- giving signed consent to participate.
Age in the registry: 18 years to 45 years · Sex: Female · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Akershus University Hospital Coordinator of this site? Confirm its status | Lillestrøm | Norway | Unknown status |
Related publications
- Effect of pain management, supervised exercise, and pelvic floor muscle training on sexual function in women with endometriosis: A randomized controlled trial.Acta Obstet Gynecol Scand · 2026 · PMID 42483830
This page is information, not medical advice. Discuss any trial with your doctor.