NCT05094271CompletedPhase 1
Is Obstructive Sleep Apnea Important in the Development of Alzheimer's Disease?
Source: ClinicalTrials.gov · Last updated 11 May 2026
Brief summary (registry, in English)
Obstructive sleep apnea (OSA) is common in older adults and has recently been implicated in pathogenesis of Alzheimer's disease (AD). Research has shown that sleep disruptions have caused memory impairment. Sleep apnea is a form of sleep disruption. We would like to examine how obstructive sleep apnea may contribute to the progression of Alzheimer's disease.
- Status (registry)
- Completed
- Phase (registry)
- Phase 1
- Study type
- Interventional
- Enrollment
- 182 (actual)
- First submitted
- 22 Oct 2021
- Start date
- 8 Oct 2021
- Primary completion date
- 12 Jun 2025
- Lead sponsor
- University of California, San Diego
- Diseases
- Alzheimer disease
- NCT number
- NCT05094271
What you commit to
- Study type: Interventional · Phase 1
- Participants enrolled: 182
- From 8 Oct 2021 to the primary completion date, 12 Jun 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Participants in whom magnetic resonance imaging Magnetic Resonance Imaging \[MRI\] is contraindicated including, but not limited to, those with a pacemaker, presence of metallic fragments near the eyes or spinal cord, or cochlear implant
- Current drug or alcohol abuse/dependence
Other illness
- History of COPD or asthma
- Heart Failure Class III or IV, unstable cardiovascular disease, or uncontrolled hypertension
- Neuromuscular Disease
- Presence of a brain tumor or lobar stroke
Other
- Currently smoking
- Drowsy Driving (ESS \> 18/24)
- Inability to complete study procedures, such as questionnaire that are only available/validated in English
- Lack of decisional capacity to provide informed consent
- Prisoners
Who the study is looking for
- Age 65-85 years
- Gender: Men or Women
- MOCA \> 26
- Independently living and able to drive
- OSA (AHI ≥ 15/h) or no OSA
- Subjects must consent to waiving their right to obtain their PHS score (since the score is not yet actionable and could lead to social stress and ethical dilemmas)
Age in the registry: 65 years to 85 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| UCSD Sleep Research Coordinator of this site? Confirm its status | La Jolla | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.