NCT05101863Completed
FMRI of Dietary Decision-making in Food Addicted Participants Compared to Non-food Addicted Participants
How a Patient's Words Change the Rewarding Value of Food: Mapping the Neurocognitive Shift Generated by Motivational Interviewing During the Therapy of Food Addiction Onto the Brain - MOTIVFOOD
Source: ClinicalTrials.gov · Last updated 22 Sept 2026
Brief summary (registry, in English)
Why in some situations can words soothe our cravings? This research proposal will test the power of self-generated reasons for behavioural change in food addiction, which concerns about three out of ten persons and causes major life hazards such as obesity, diabetes and cancer. While food addiction is becoming more and more frequent in western societies, not much is known about its underlying neurocognitive mechanisms and how to tackle it. This study aims to investigate if and why certain types of affirmation-based therapies such as motivational interviewing (MI) are beneficial for the treatment of food addiction. The working hypothesis proposes that cognitive regulation-based self-control underpins the neurocognitive shift of a patient's willingness to change addictive behaviour, generated by the patient during MI therapy of food addiction. To test this hypothesis this study combines functional magnetic resonance imaging with behavioural testing of dietary decision-making following a participant's change or sustain talk statements. It will compare three groups of participants with and without food addiction and obesity and lean controls. This study will contribute to the improvement of therapies based upon talking oneself in and out of addiction promoting goals. Findings will provide a better understanding of how our everyday life dietary decision-environments prompt good intentions such as improving long-term nutritional quality to actual behaviours such as forgoing immediate desire.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 56 (actual)
- First submitted
- 19 Oct 2021
- Start date
- 15 Sept 2022
- Primary completion date
- 13 Sept 2024
- Lead sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
- Diseases
- Obesity
- NCT number
- NCT05101863
What you commit to
- Study type: Observational
- Participants enrolled: 56
- From 15 Sept 2022 to the primary completion date, 13 Sept 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other
- bad MRI quality
- drop out
Criteria the registry did not label
- Group: Normal-weight, NON-food addicted control participants
- no food addiction, no eating disorder, no nutrition troubles, no weight management troubles
- BMI: between 18.5 kg/m2 and 25 kg/m2
- age 18 to 70 years
- right-handed
- male / female
- able to understand instructions and perform tasks
- no psychiatric or neurological disorders
- no drug abuse
- written and informed consent
- Group: obese, food addicted
- BMI \>= 30 kg/m2
- YFAS score \> = 2
- no other addictions
- age 18 to 70 years
- right-handed
- male / female
- able to understand instructions and perform tasks
- no recently diagnosed psychiatric or neurological disorders
- no drug abuse
- written and informed consent
- Group: obese, NON-food addicted
- age 18 to 70 years
- BMI \>= 30 kg/m2
- YFAS score \< =1
- no other addictions
- right-handed
- male / female
- able to understand instructions and perform tasks
- no recently diagnosed psychiatric or neurological disorders
- no drug abuse
- written and informed consent
Age in the registry: 18 years to 70 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Liane Schmidt Coordinator of this site? Confirm its status | Paris | France | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.