NCT05102929Recruiting
Enhancing Prefrontal Oscillations and Working Memory in Early-course Schizophrenia
Enhancing Prefrontal Oscillatory Activity and Working Memory Performance With Noninvasive Brain Stimulation in Early-course Schizophrenia
Source: ClinicalTrials.gov · Last updated 11 Aug 2026
Brief summary (registry, in English)
This study will investigate the effects of intermittent Theta Burst Stimulation (iTBS) on natural oscillatory frequency of the dorsolateral prefrontal cortex (DLPFC) and working memory in early-course schizophrenia (EC-SCZ). Transcranial magnetic stimulation (TMS) will be used to evoke oscillatory activity, and EEG will record the responses of EC-SCZ participants. A working memory task will also be incorporated in order to determine how DLPFC natural frequency (NF) is related to working memory performance. iTBS (active or sham) will be administered, then the oscillatory activity of DLPFC and working memory performance will be reassessed. The overarching goal is to determine whether iTBS can acutely enhance the oscillatory activity of the DLPFC and to evaluate the relationship between changes in the DLPFC and working memory performance.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 75 (estimated)
- First submitted
- 20 Oct 2021
- Start date
- 5 Nov 2021
- Primary completion date
- Oct 2026
- Lead sponsor
- Fabio Ferrarelli
- Diseases
- Schizophrenia
- NCT number
- NCT05102929
What you commit to
- Study type: Interventional
- Planned participants: 75
- From 5 Nov 2021 to the primary completion date, Oct 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- DSM intellectual developmental disorder
- medical illness affecting brain structure or function
- significant neurologic disorder (e.g. seizure disorder)
- personal history or family history of epilepsy
- history of electroconvulsive therapy
- diabetes with associated seizures, loss of sensation/weakness in arms or legs, or momentary LOC
- a psychotic illness with a temporal relation to substance use or head injury.
Other
- significant head injury
- inability to provide informed consent
- concussion with loss of consciousness (LOC) greater than 10 minutes
- pregnancy or postpartum (\<6 weeks after delivery or miscarriage), as determined by self-report
- current or past co-morbidity for alcohol or psychoactive substance dependence
- substance abuse, other than cannabis and/or alcohol, within the past one year
Who the study is looking for
- ages 18-40 years
- DSM diagnoses of Schizophrenia Spectrum Axis I disorders
- a duration of less than three years from beginning of psychosis, defined by report of symptoms and/or history of treatment, based on clinical guidelines employed in our UPMC psychoses clinics in Pittsburgh.
Age in the registry: 18 years to 40 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Pittsburgh Coordinator of this site? Confirm its status | Pittsburgh | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.